Search or filter publications

Filter by type:

Filter by publication type

Filter by year:

to

Results

  • Showing results for:
  • Reset all filters

Search results

  • Journal article
    Cook S, Eggen AE, Hopstock L, Malyutina S, Shapkina M, Kudryavtsev A, Melbye H, Quint Jet al., 2021,

    Chronic Obstructive Pulmonary Disease (COPD) in population studies in Russia and Norway: comparison of prevalence, awareness and management

    , International Journal of COPD, Vol: 16, Pages: 1353-1368, ISSN: 1176-9106

    Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Despite a high prevalence of smoking and respiratory symptoms, two recent population-based studies in Russia found a relatively low prevalence of obstructive lung function. Here, we investigated the prevalence of both obstructive lung disease and respiratory symptoms in a population-based study conducted in two Russian cities and compared the findings with a similar study from Norway conducted in the same time period.Methods: The study population was a sub-sample of participants aged 40– 69 years participating in the Know Your Heart (KYH) study in Russia in 2015– 18 (n=1883) and in the 7th survey of the Tromsø Study (n=5271) carried out in Norway in 2015– 16 (Tromsø 7) who participated in spirometry examinations. The main outcome was obstructive lung function (FEV1/FVC ratio< lower limit of normal on pre-bronchodilator spirometry examination) with and without respiratory symptoms (chronic cough and breathlessness). In those with obstructive lung function, awareness (known diagnosis) and management (use of medications, smoking cessation) were compared.Results: The age-standardized prevalence of obstructive lung function was similar among men in both studies (KYH 11.0% vs Tromsø 7 9.8%, p=0.21) and higher in the Norwegian (9.4%) than Russian (6.8%) women (p=0.006). In contrast, the prevalence of obstructive lung function plus respiratory symptoms was higher in Russian men (KYH 8.3% vs Tromsø 7 4.7%, p< 0.001) but similar in women (KYH 5.9% vs Tromsø 7 6.4%, p=0.18). There was a much higher prevalence of respiratory symptoms in Russian than Norwegian participants of both sexes regardless of presence of obstructive lung function.Conclusion: The prevalence of respiratory symptoms was strikingly high among Russian participants but this was not explained by a higher burden of obstructive lung function on
  • Journal article
    Whittaker HR, Gulea C, Koteci A, Kallis C, Morgan AD, Iwundu C, Weeks M, Gupta R, Quint JKet al., 2021,

    Post-acute COVID-19 sequelae in cases managed in the community or hospital in the UK: a population based study

    <jats:title>Abstract</jats:title><jats:sec><jats:title>Objective</jats:title><jats:p>To compare post-COVID-19 sequelae between hospitalised and non-hospitalised individuals</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>Population-based cohort study</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>1,383 general practices in England contributing to Clinical Practice Research Database Aurum</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>46,687 COVID-19 cases diagnosed between 1<jats:sup>st</jats:sup> August to 17<jats:sup>th</jats:sup> October 2020 (45.4% male; mean age 40), either hospitalised within two weeks of diagnosis or non-hospitalised, and followed-up for a maximum of three months.</jats:p></jats:sec><jats:sec><jats:title>Main outcome measures</jats:title><jats:p>Event rates of new symptoms, diseases, prescriptions and healthcare utilisation in hospitalised and non-hospitalised individuals, with between-group comparison using Cox regression. Outcomes compared at 6 and 12 months prior to index date, equating to first UK wave and pre-pandemic. Non-hospitalised group outcomes stratified by age and sex.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>45,272 of 46,687 people were non-hospitalised; 1,415 hospitalised. Hospitalised patients had higher rates of 13/26 symptoms and 11/19 diseases post-COVID-19 than the community group, received more prescriptions and utilised more healthcare. The largest differences were noted for rates per 100,000 person-weeks [95%CI] of <jats:italic>breathlessness:</jats:italic> 536 [432 to 663] v. 85 [77 to 93]; <jats:italic>joint pain:</jats:italic> 295 [221 to 392] v. 168 [158 to 179]
  • Journal article
    Mansfield KE, Mathur R, Tazare J, Henderson AD, Mulick AR, Carreira H, Matthews AA, Bidulka P, Gayle A, Forbes H, Cook S, Wong AYS, Strongman H, Wing K, Warren-Gash C, Cadogan SL, Smeeth L, Hayes JF, Quint JK, McKee M, Langan SMet al., 2021,

    Indirect acute effects of the COVID-19 pandemic on physical and mental health in the UK: a population-based study

    , The Lancet Digital Health, Vol: 3, Pages: e217-e230, ISSN: 2589-7500

    BACKGROUND: There are concerns that the response to the COVID-19 pandemic in the UK might have worsened physical and mental health, and reduced use of health services. However, the scale of the problem is unquantified, impeding development of effective mitigations. We aimed to ascertain what has happened to general practice contacts for acute physical and mental health outcomes during the pandemic. METHODS: Using de-identified electronic health records from the Clinical Research Practice Datalink (CPRD) Aurum (covering 13% of the UK population), between 2017 and 2020, we calculated weekly primary care contacts for selected acute physical and mental health conditions: anxiety, depression, self-harm (fatal and non-fatal), severe mental illness, eating disorder, obsessive-compulsive disorder, acute alcohol-related events, asthma exacerbation, chronic obstructive pulmonary disease exacerbation, acute cardiovascular events (cerebrovascular accident, heart failure, myocardial infarction, transient ischaemic attacks, unstable angina, and venous thromboembolism), and diabetic emergency. Primary care contacts included remote and face-to-face consultations, diagnoses from hospital discharge letters, and secondary care referrals, and conditions were identified through primary care records for diagnoses, symptoms, and prescribing. Our overall study population included individuals aged 11 years or older who had at least 1 year of registration with practices contributing to CPRD Aurum in the specified period, but denominator populations varied depending on the condition being analysed. We used an interrupted time-series analysis to formally quantify changes in conditions after the introduction of population-wide restrictions (defined as March 29, 2020) compared with the period before their introduction (defined as Jan 1, 2017 to March 7, 2020), with data excluded for an adjustment-to-restrictions period (March 8-28). FINDINGS: The overall population included 9 863 903 individuals
  • Journal article
    Whittaker H, Bloom C, Morgan A, Jarvis D, Kiddle S, Quint Jet al., 2021,

    Accelerated FEV1 decline and risk of cardiovascular disease and mortality in a primary care population of COPD patients

    , European Respiratory Journal, Vol: 57, ISSN: 0903-1936

    Accelerated lung function decline has been associated with increased risk of cardiovascular disease (CVD) in a general population, but little is known about this association in chronic obstructive pulmonary disease (COPD). We investigated the association between accelerated lung function decline and CVD outcomes and mortality in a primary care COPD population.COPD patients without a history of CVD were identified in the Clinical Practice Research Datalink (CPRD-GOLD) primary care dataset (n=36 282). Accelerated FEV1 decline was defined using the fastest quartile of the COPD population's decline. Cox regression assessed the association between baseline accelerated FEV1 decline and a composite CVD outcome over follow-up (myocardial infarction, ischaemic stroke, heart failure, atrial fibrillation, coronary artery disease, and CVD mortality). The model was adjusted for age, gender, smoking status, BMI, history of asthma, hypertension, diabetes, statin use, mMRC dyspnoea, exacerbation frequency, and baseline FEV1 percent predicted.6110 (16.8%) COPD patients had a CVD event during follow-up; median length of follow-up was 3.6 years [IQR 1.7–6.1]). Median rate of FEV1 decline was –19.4 mL·year−1 (IQR, –40.5 to 1.9); 9095 (25%) patients had accelerated FEV1 decline (>–40.5 mL·year−1), 27 287 (75%) did not (≤ –40.5 mL·year−1). Risk of CVD and mortality was similar between patients with and without accelerated FEV1 decline (HRadj 0.98 [95%CI, 0.90–1.06]). Corresponding risk estimates were 0.99 (95%CI 0.83–1.20) for heart failure, 0.89 (95%CI 0.70–1.12) for myocardial infarction, 1.01 (95%CI 0.82–1.23) for stroke, 0.97 (95%CI 0.81–1.15) for atrial fibrillation, 1.02 (95%CI 0.87–1.19) for coronary artery disease, and 0.94 (95%CI 0.71–1.25) for CVD mortality. Rather, risk of CVD was associated with mMRC score ≥2 and ≥2 exacerbations in the year prior.CVD out
  • Journal article
    Jones R, Davis A, Stanley B, Julious S, Ryan D, Jackson DJ, Halpin DMG, Hickman K, Pinnock H, Quint JK, Khunti K, Heaney LG, Oliver P, Siddiqui S, Pavord I, Jones DHM, Hyland M, Ritchie L, Young P, Megaw T, Davis S, Walker S, Holgate S, Beecroft S, Kemppinen A, Appiagyei F, Roberts E-J, Preston M, Hardjojo A, Carter V, van Melle M, Price Det al., 2021,

    Risk Predictors and Symptom Features of Long COVID Within a Broad Primary Care Patient Population Including Both Tested and Untested Patients

    , PRAGMATIC AND OBSERVATIONAL RESEARCH, Vol: 12, Pages: 93-104, ISSN: 1179-7266
  • Journal article
    Coid J, Gonzalez RA, Kallis C, Zhang Y, Liu Y, Wood J, Quigg Z, Ullrich Set al., 2020,

    Gang membership and sexual violence: associations with childhood maltreatment and psychiatric morbidity

    , BRITISH JOURNAL OF PSYCHIATRY, Vol: 217, Pages: 583-590, ISSN: 0007-1250
  • Journal article
    Coid J, Gonzalez Rodriguez R, Kallis C, Zhang Y, Bhui K, De Stavola B, Bebbington P, Ullrich Set al., 2020,

    Ethnic disparities in psychotic experiences explained by area-level syndemic effects

    , BRITISH JOURNAL OF PSYCHIATRY, Vol: 217, Pages: 555-561, ISSN: 0007-1250
  • Journal article
    Whittaker H, Quint JK, 2020,

    Using routine health data for research: the devil is in the detail

    , Thorax, Vol: 75, Pages: 714-715, ISSN: 0040-6376
  • Journal article
    Kiddle S, Whittaker H, Seaman S, Quint Jet al., 2020,

    Prediction of five-year mortality after COPD diagnosis using primary care records

    , PLoS One, Vol: 15, ISSN: 1932-6203

    Accurate prognosis information after a diagnosis of chronic obstructive pulmonary disease (COPD) would facilitate earlier and better informed decisions about the use of prevention strategies and advanced care plans. We therefore aimed to develop and validate an accurate prognosis model for incident COPD cases using only information present in general practitioner (GP) records at the point of diagnosis. Incident COPD patients between 2004–2012 over the age of 35 were studied using records from 396 general practices in England. We developed a model to predict all-cause five-year mortality at the point of COPD diagnosis, using 47,964 English patients. Our model uses age, gender, smoking status, body mass index, forced expiratory volume in 1-second (FEV1) % predicted and 16 co-morbidities (the same number as the Charlson Co-morbidity Index). The performance of our chosen model was validated in all countries of the UK (N = 48,304). Our model performed well, and performed consistently in validation data. The validation area under the curves in each country varied between 0.783–0.809 and the calibration slopes between 0.911–1.04. Our model performed better in this context than models based on the Charlson Co-morbidity Index or Cambridge Multimorbidity Score. We have developed and validated a model that outperforms general multimorbidity scores at predicting five-year mortality after COPD diagnosis. Our model includes only data routinely collected before COPD diagnosis, allowing it to be readily translated into clinical practice, and has been made available through an online risk calculator
  • Journal article
    Kallis C, Dixon P, Silberberg B, Affarah L, Shawihdi M, Grainger R, Prospero N, Pearson M, Marson A, Ramakrishnan S, Richardson P, Hood S, Bodger Ket al., 2020,

    Reducing variation in hospital mortality for alcohol-related liver disease in North West England

    , ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 52, Pages: 182-195, ISSN: 0269-2813

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://www.imperial.ac.uk:80/respub/WEB-INF/jsp/search-t4-html.jsp Request URI: /respub/WEB-INF/jsp/search-t4-html.jsp Query String: id=1278&limit=10&page=5&respub-action=search.html Current Millis: 1737112185272 Current Time: Fri Jan 17 11:09:45 GMT 2025