@article{Koteci:2022:10.1186/s12890-022-01973-5,
author = {Koteci, A and Morgan, A and Portas, L and Whittaker, H and Kallis, C and George, P and Quint, J},
doi = {10.1186/s12890-022-01973-5},
journal = {BMC Pulmonary Medicine},
pages = {1--11},
title = {Left-sided heart failure burden and mortality in idiopathic pulmonary fibrosis: a population-based study},
url = {http://dx.doi.org/10.1186/s12890-022-01973-5},
volume = {22},
year = {2022}
}
TY - JOUR
AB - BackgroundCardiovascular disease is prevalent in idiopathic pulmonary fibrosis (IPF), yet the extent of left-sided heart failure (HF) burden, whether this has changed with time and whether HF impacts mortality risk in these patients are unknown. The aims of this study were therefore to determine the temporal trends in incidence and prevalence of left-sided HF in patients with IPF in England and compare these to published estimates in the general population and those with comparable chronic respiratory conditions such as chronic obstructive pulmonary disease (COPD), as well as determine the risk of all-cause and cause-specific mortality in patients with comorbid left-sided HF and IPF at population-level using electronic healthcare data.MethodsClinical Practice Research Datalink (CPRD) Aurum primary-care data linked to mortality and secondary-care data was used to identify IPF patients in England. Left-sided HF prevalence and incidence rates were calculated for each calendar year between 2010 and 2019, stratified by age and sex. Risk of all-cause, cardiovascular and IPF-specific mortality was calculated using multivariate Cox regression.ResultsFrom 40,577patients with an IPF code in CPRD Aurum, 25, 341 IPF patients met inclusion criteria. Left-sided HF prevalence decreased from 33.4% (95% CI 32.2–34.6) in 2010 to 20.9% (20.0–21.7) in 2019. Left-sided HF incidence rate per 100 person-years (95% CI) remained stable between 2010 and 2017 but decreased from 4.3 (3.9–4.8) in 2017 to 3.4 (3.0–3.9) in 2019. Throughout follow-up, prevalence and incidence were higher in men and with increasing age. Comorbid HF was associated with poorer survival (adjusted HR (95%CI) 1.08 (1.03–1.14) for all-cause mortality; 1.32 (1.09–1.59) for cardiovascular mortality).ConclusionLeft-sided HF burden in IPF patients in England remains high, with incidence almost 4 times higher than in COPD, a comparable lung disease with similar cardiovascular risk factors.
AU - Koteci,A
AU - Morgan,A
AU - Portas,L
AU - Whittaker,H
AU - Kallis,C
AU - George,P
AU - Quint,J
DO - 10.1186/s12890-022-01973-5
EP - 11
PY - 2022///
SN - 1471-2466
SP - 1
TI - Left-sided heart failure burden and mortality in idiopathic pulmonary fibrosis: a population-based study
T2 - BMC Pulmonary Medicine
UR - http://dx.doi.org/10.1186/s12890-022-01973-5
UR - https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890-022-01973-5
UR - http://hdl.handle.net/10044/1/97013
VL - 22
ER -