Citation

BibTex format

@article{Tolosana:2025:10.1038/s41467-024-55391-8,
author = {Tolosana, I and Willis, K and Gribble, M and Phillimore, L and Burt, A and Nolan, T and Crisanti, A and Bernardini, F},
doi = {10.1038/s41467-024-55391-8},
journal = {Nat Commun},
title = {A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.},
url = {http://dx.doi.org/10.1038/s41467-024-55391-8},
volume = {16},
year = {2025}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Genetic control - the deliberate introduction of genetic traits to control a pest or vector population - offers a powerful tool to augment conventional mosquito control tools that have been successful in reducing malaria burden but that are compromised by a range of operational challenges. Self-sustaining genetic control strategies have shown great potential in laboratory settings, but hesitancy due to their invasive and persistent nature may delay their implementation. Here, instead, we describe a self-limiting strategy, designed to have geographically and temporally restricted effect, based on a Y chromosome-linked genome editor (YLE). The YLE comprises a CRISPR-Cas9 construct that is always inherited by males yet generates an autosomal dominant mutation that is transmitted to over 90% of the offspring and results in female-specific sterility. To our knowledge, our system represents a pioneering approach in the engineering of the Y chromosome to generate a genetic control strain for mosquitoes. Mathematical modelling shows that this YLE technology is up to seven times more efficient for population suppression than optimal versions of other self-limiting strategies, such as the widely used Sterile Insect Technique or the Release of Insects carrying a Dominant Lethal gene.
AU - Tolosana,I
AU - Willis,K
AU - Gribble,M
AU - Phillimore,L
AU - Burt,A
AU - Nolan,T
AU - Crisanti,A
AU - Bernardini,F
DO - 10.1038/s41467-024-55391-8
PY - 2025///
TI - A Y chromosome-linked genome editor for efficient population suppression in the malaria vector Anopheles gambiae.
T2 - Nat Commun
UR - http://dx.doi.org/10.1038/s41467-024-55391-8
UR - https://www.ncbi.nlm.nih.gov/pubmed/39747012
VL - 16
ER -