@article{Sintou:2020:10.3389/fcell.2020.00695,
author = {Sintou, A and Mansfield, C and Iacob, A-O and Chowdhury, RA and Narodden, S and Rothery, SM and Podoveo, R and Sanchez, Alonso JL and Ferraro, E and Swiatlowska, P and Harding, S and Prasad, S and Rosenthal, N and Gorelik, J and Sattler, S},
doi = {10.3389/fcell.2020.00695},
journal = {Frontiers in Cell and Developmental Biology},
pages = {1--12},
title = {Mediastinal lymphadenopathy, class-switched auto-antibodies and myocardial immune-complexes during heart failure in rodents and humans},
url = {http://dx.doi.org/10.3389/fcell.2020.00695},
volume = {8},
year = {2020}
}

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TY  - JOUR
AB  - Mediastinal lymphadenopathy and auto-antibodies are clinical phenomena during ischemicheart failure pointing to an autoimmune response against the heart. T and B cell have beenconvincingly demonstrated to be activated after myocardial infarction, a prerequisite for thegeneration of mature auto-antibodies. Yet, little is known about the immunoglobulin isotyperepertoire thus pathological potential of anti-heart auto-antibodies during heart failure.We obtained human myocardial tissue from ischemic heart failure patients and inducedexperimental MI in rats. We found that anti-heart autoimmunity persists during heart failure.Rat mediastinal lymph nodes are enlarged and contain active secondary follicles with matureisotype-switched IgG2a B cells. Mature IgG2a auto-antibodies specific for cardiac antigens arepresent in rat heart failure serum, and IgG and complement C3 deposits are evident in heartfailure tissue of both rats and human patients.Previously established myocardial inflammation, and the herein provided proof of B cellmaturation in lymph nodes and myocardial deposition of mature auto-antibodies, provide allthe hallmark signs of an established autoimmune response in chronic heart failure.
AU  - Sintou,A
AU  - Mansfield,C
AU  - Iacob,A-O
AU  - Chowdhury,RA
AU  - Narodden,S
AU  - Rothery,SM
AU  - Podoveo,R
AU  - Sanchez,Alonso JL
AU  - Ferraro,E
AU  - Swiatlowska,P
AU  - Harding,S
AU  - Prasad,S
AU  - Rosenthal,N
AU  - Gorelik,J
AU  - Sattler,S
DO  - 10.3389/fcell.2020.00695
EP  - 12
PY  - 2020///
SN  - 2296-634X
SP  - 1
TI  - Mediastinal lymphadenopathy, class-switched auto-antibodies and myocardial immune-complexes during heart failure in rodents and humans
T2  - Frontiers in Cell and Developmental Biology
UR  - http://dx.doi.org/10.3389/fcell.2020.00695
UR  - https://www.frontiersin.org/articles/10.3389/fcell.2020.00695/full
UR  - http://hdl.handle.net/10044/1/81380
VL  - 8
ER  - 

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