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Synthetic Biology underpins advances in the bioeconomy

Biological systems - including the simplest cells - exhibit a broad range of functions to thrive in their environment. Research in the Imperial College Centre for Synthetic Biology is focused on the possibility of engineering the underlying biochemical processes to solve many of the challenges facing society, from healthcare to sustainable energy. In particular, we model, analyse, design and build biological and biochemical systems in living cells and/or in cell extracts, both exploring and enhancing the engineering potential of biology. 

As part of our research we develop novel methods to accelerate the celebrated Design-Build-Test-Learn synthetic biology cycle. As such research in the Centre for Synthetic Biology highly multi- and interdisciplinary covering computational modelling and machine learning approaches; automated platform development and genetic circuit engineering ; multi-cellular and multi-organismal interactions, including gene drive and genome engineering; metabolic engineering; in vitro/cell-free synthetic biology; engineered phages and directed evolution; and biomimetics, biomaterials and biological engineering.

Publications

Citation

BibTex format

@article{Liberante:2021:10.1016/j.coisb.2020.11.003,
author = {Liberante, FG and Ellis, T},
doi = {10.1016/j.coisb.2020.11.003},
journal = {Current Opinion in Systems Biology},
pages = {1--10},
title = {From kilobases to megabases: Design and delivery of large DNA constructs into mammalian genomes},
url = {http://dx.doi.org/10.1016/j.coisb.2020.11.003},
volume = {25},
year = {2021}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - As DNA synthesis has become cheaper, it has made assembly of larger and larger genes possible. To fully realise this opportunity for a new era of synthetic biology in mammals, a number of gaps are beginning to be addressed in the design, synthesis, assembly and delivery of DNA constructs into large genomes. While current DNA design software is still inadequate for complex mammalian genomes, editing large bacterial artificial chromosomes is now easier. Newer viral technologies, such as herpes simplex virus, have been adapted for assembly of mammalian artificial chromosomes. Further advances in genome engineering, such as CRISPR- and Retron-based systems, will simplify targeted insertion of big DNA – all promising an exciting future for this field.
AU - Liberante,FG
AU - Ellis,T
DO - 10.1016/j.coisb.2020.11.003
EP - 10
PY - 2021///
SP - 1
TI - From kilobases to megabases: Design and delivery of large DNA constructs into mammalian genomes
T2 - Current Opinion in Systems Biology
UR - http://dx.doi.org/10.1016/j.coisb.2020.11.003
VL - 25
ER -