BibTex format

author = {Barnard, A and Miles, JA and Burslem, GM and Barker, AM and Wilson, AJ},
doi = {10.1039/C4OB02066A},
journal = {Organic & Biomolecular Chemistry},
pages = {258--264},
title = {Multivalent helix mimetics for PPI-inhibition},
url = {},
volume = {13},
year = {2014}

RIS format (EndNote, RefMan)

AB - The exploitation of multivalent ligands for the inhibition of protein–protein interactions has not yet been explored as a supramolecular design strategy. This is despite the fact that protein–protein interactions typically occur within the context of multi-protein complexes and frequently exploit avidity effects or co-operative binding interactions to achieve high affinity interactions. In this paper we describe preliminary studies on the use of a multivalent N-alkylated aromatic oligoamide helix mimetic for inhibition of p53/hDM2 and establish that protein dimerisation is promoted, rather than enhanced binding resulting from a higher effective concentration of the ligand.
AU - Barnard,A
AU - Miles,JA
AU - Burslem,GM
AU - Barker,AM
AU - Wilson,AJ
DO - 10.1039/C4OB02066A
EP - 264
PY - 2014///
SN - 1477-0539
SP - 258
TI - Multivalent helix mimetics for PPI-inhibition
T2 - Organic & Biomolecular Chemistry
UR -
UR -
VL - 13
ER -