The Network aims to promote multi-disciplinary approaches to address challenging vaccine-related questions. This page contains a curated list of publications that highlight high-impact and collaborative approaches.

Citation

BibTex format

@article{Mehring-Le:2016:10.1097/QAD.0000000000000923,
author = {Mehring-Le, Doare KEK and Allen, L and Gorringe, A and Heath, PT and Hesseling, A and Kampmann, B and Jones, CE},
doi = {10.1097/QAD.0000000000000923},
journal = {AIDS},
pages = {471--475},
title = {Placental transfer of anti-Group B Streptococcus IgG antibody subclasses from HIV-infected and uninfected women to their uninfected infants},
url = {http://dx.doi.org/10.1097/QAD.0000000000000923},
volume = {30},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Objectives: Placental antibody transfer is impaired in the context of HIV infection, which may render HIV-exposed, uninfected infants vulnerable to group B Streptococcus (GBS) disease. The GBS antibody response predominately consists of immunoglobulin G2 (IgG2) antibody. Thus we determined whether concentration and placental transfer of anti-GBS antibody subclasses was altered in HIV-infected compared with HIV-uninfected mothers.Design: A retrospective analysis of anti-GBS antibody subclasses in 38 HIV-infected and 33 HIV-uninfected mothers and their uninfected infants.Methods: Sera were analysed using a novel flow cytometric assay that quantified binding of IgG1, IgG2, IgG3 and IgG4 to serotype (ST)Ia, STIII and STV GBS bacteria.Results: IgG2 binding to GBS STIa and V was lower in HIV-infected women compared with HIV-uninfected women. Moreover, IgG2 binding to GBS STIa was also lower in HIV-exposed, uninfected infants compared with unexposed infants. However, there were no statistically significant differences in the transplacental transfer ratio of IgG2 for any GBS serotype. The transplacental transfer of total IgG was reduced for GBS STIII and V and IgG1 subclass for STIII; placental transfer of all other subclasses was comparable in HIV-affected and HIV-unaffected pregnancies.Conclusion: Anti-GBS IgG2 placental transfer is not affected by HIV infection. This is important for functional antibody against the capsular polysaccharide of GBS and provides confidence that maternal GBS vaccination may result in functional activity in HIV-infected and uninfected women.
AU - Mehring-Le,Doare KEK
AU - Allen,L
AU - Gorringe,A
AU - Heath,PT
AU - Hesseling,A
AU - Kampmann,B
AU - Jones,CE
DO - 10.1097/QAD.0000000000000923
EP - 475
PY - 2016///
SN - 0269-9370
SP - 471
TI - Placental transfer of anti-Group B Streptococcus IgG antibody subclasses from HIV-infected and uninfected women to their uninfected infants
T2 - AIDS
UR - http://dx.doi.org/10.1097/QAD.0000000000000923
UR - http://hdl.handle.net/10044/1/26405
VL - 30
ER -