@article{Zhou:2021:10.21037/qims-20-501,
author = {Zhou, Z and Wang, R and Wang, H and Liu, Y and Lu, D and Sun, Z and Yang, G and Xu, L},
doi = {10.21037/qims-20-501},
journal = {Quantitative imaging in medicine and surgery},
pages = {510--520},
title = {Myocardial extracellular volume fraction quantification in an animal model of the doxorubicin-induced myocardial fibrosis: a synthetic hematocrit method using 3T cardiac magnetic resonance},
url = {http://dx.doi.org/10.21037/qims-20-501},
volume = {11},
year = {2021}
}

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TY  - JOUR
AB  - Background: Visualization of diffuse myocardial fibrosis is challenging and mainly relies on histology.Cardiac magnetic resonance (CMR), which uses extracellular contrast agents, is a rapidly developingtechnique for measuring the extracellular volume (ECV). The objective of this study was to evaluate thefeasibility of the synthetic myocardial ECV fraction based on 3.0 T CMR compared with the conventionalECV fraction.Methods: This study was approved by the local animal care and ethics committee. Fifteen beagle modelswith diffuse myocardial fibrosis, including 12 experimental and three control subjects, were generatedby injecting doxorubicin 30 mg/m2 intravenously every three weeks for 24 weeks. Short-axis (SAX) and4-chamber long-axis (LAX) T1 maps were acquired for both groups. The association between hematocrit(Hct) and native T1blood was derived from 9 non-contrast CMR T1 maps of 3 control beagles using regressionanalysis. Synthetic ECV was then calculated using the synthetic Hct and compared with conventional ECVat baseline and the 16th and 24th week after doxorubicin administration. The collagen volume fraction (CVF)value was measured on digital biopsy samples. Bland-Altman plots were used to analyze the agreementbetween conventional and synthetic ECV. Correlation analyses were performed to explore the associationamong conventional ECV, synthetic ECV, CVF, and left ventricular ejection fraction (LVEF).Results: The regression model synthetic Hct = 816.46R1blood − 0.01 (R2=0.617; P=0.012) was used topredict the Hct from native T1blood values. The conventional and synthetic ECV fractions of experimentalanimals at the 16th and 24th week after modeling were significantly higher than those measured at the baseline(31.4%±2.2% and 36.3%±2.1% vs. 22.9%±1.7%; 29.9%±2.4% and 36.1%±2.6% vs. 22.0%±2.4%; all withP<0.05). Bland-Altman plots showed a bias (1.0%) between conventional and synthetic ECV with 95% limitsof agreement
AU  - Zhou,Z
AU  - Wang,R
AU  - Wang,H
AU  - Liu,Y
AU  - Lu,D
AU  - Sun,Z
AU  - Yang,G
AU  - Xu,L
DO  - 10.21037/qims-20-501
EP  - 520
PY  - 2021///
SN  - 2223-4292
SP  - 510
TI  - Myocardial extracellular volume fraction quantification in an animal model of the doxorubicin-induced myocardial fibrosis: a synthetic hematocrit method using 3T cardiac magnetic resonance
T2  - Quantitative imaging in medicine and surgery
UR  - http://dx.doi.org/10.21037/qims-20-501
UR  - http://qims.amegroups.com/article/view/55012/html
UR  - http://hdl.handle.net/10044/1/83817
VL  - 11
ER  - 

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