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• Journal article
  Vilar R, 2008,

  Anion templates in synthesis and dynamic combinatorial libraries

  , RECOGNITION OF ANIONS, Vol: 129, Pages: 175-206, ISSN: 0081-5993
  • Author Web Link
  • Open Access Link
  • Cite
  • Citations: 84
• Journal article
  Tovilla JA, Carlqvist P, Benet-Buchholz J, Maseras F, Vilar Ret al., 2007,

  Di-palladium complexes with urea-containing ligands as anion receptors

  , SUPRAMOLECULAR CHEMISTRY, Vol: 19, Pages: 599-611, ISSN: 1061-0278
  • Author Web Link
  • Cite
  • Citations: 8
• Book chapter
  Vilar R, 2007,

  PET Imaging in Chemical Biology

  , Chemical Biology: Applications and Techniques, Pages: 217-229, ISBN: 9780470090640
  • Cite
• Journal article
  Shalom D, Wootton RCR, Winkle RF, Cottam BF, Vilar R, deMello AJ, Wilde CPet al., 2007,

  Synthesis of thiol functionalized gold nanoparticles using a continuous flow microfluidic reactor

  , MATERIALS LETTERS, Vol: 61, Pages: 1146-1150, ISSN: 0167-577X
  • Author Web Link
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  • Citations: 92
• Journal article
  Gimeno N, Formentin P, Steinke JHG, Vilar Ret al., 2007,

  Phenylphosphoric acid as a new additive to inhibit olefin isomerisation in ruthenium-catalysed metathesis reactions

  , EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Vol: 2007, Pages: 918-924, ISSN: 1434-193X
  • Author Web Link
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  • Citations: 32
• Journal article
  Reed JE, Neidle S, Vilar R, 2007,

  Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex

  , CHEMICAL COMMUNICATIONS, Pages: 4366-4368, ISSN: 1359-7345
  • Author Web Link
  • Cite
  • Citations: 93
• Journal article
  Diaz P, Tovilla JA, Ballester P, Benet-Buchholz J, Vilar Ret al., 2007,

  Synthesis, structural characterization and anion binding studies of palladium macrocycles with hydrogen-bonding ligands

  , DALTON TRANSACTIONS, Pages: 3516-3525, ISSN: 1477-9226
  • Author Web Link
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  • Citations: 27
• Journal article
  Miller PW, Long NJ, de Mello AJ, Vilar R, Audrain H, Bender D, Passchier J, Gee Aet al., 2007,

  Rapid multiphase carbonylation reactions using a micro-tube reactor: Applications in Positron Emission Tomography (PET) 11C-Radiolabelling

  , Angewandte Chemie International Edition, Vol: 46, Pages: 2875-2878
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• Journal article
  Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar Ret al., 2006,

  Synthesis and computational studies of palladium(I) dimers Pd2X2((PBu2Ph)-Bu-t)(2) (X = Br, I): Phenyl versus halide bridging modes

  , ORGANOMETALLICS, Vol: 25, Pages: 5990-5995, ISSN: 0276-7333
  • Author Web Link
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  • Citations: 18
• Journal article
  Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EW, Vilar R, Woscholski Ret al., 2006,

  A small molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN)

  , ACS Chem.Biol., Vol: 1, Pages: 780-790

  Phosphatase and tensin homologue deleted on chromosome 10 (PTEN), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling. The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes. Here we report the design and validation of a small- molecule inhibitor of PTEN. Compared with other cysteine-based phosphatases, PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate. We have exploited this feature in the design of vanadate scaffolds complexed to a range of different organic ligands, some of which show potent inhibitory activity. A vanadyl complexed to hydroxypicolinic acid was found to be a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations. The findings presented here demonstrate the applicability of a novel and specific chemical inhibitor against PTEN in research and drug development

  • Abstract
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• Journal article
  Gimeno N, Vilar R, 2006,

  Anions as templates in coordination and supramolecular chemistry

  , COORDINATION CHEMISTRY REVIEWS, Vol: 250, Pages: 3161-3189, ISSN: 0010-8545
  • Author Web Link
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  • Citations: 244
• Journal article
  Burkill HA, Vilar R, White AJP, 2006,

  Synthesis of a series of ruthenium and rhodium complexes with tridentate pyridine-based ligands containing hydrogen bonding groups

  , INORGANICA CHIMICA ACTA, Vol: 359, Pages: 3709-3722, ISSN: 0020-1693
  • Author Web Link
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  • Citations: 12
• Journal article
  Christmann U, Pantazis DA, Benet-Buchholz J, McGrady JE, Maseras F, Vilar Ret al., 2006,

  Experimental and theoretical investigations of new dinuclear palladium complexes as precatalysts for the amination of aryl chlorides

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 6376-6390, ISSN: 0002-7863
  • Author Web Link
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  • Citations: 120
• Journal article
  Reed JE, Arnal AA, Neidle S, Vilar Ret al., 2006,

  Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 128, Pages: 5992-5993, ISSN: 0002-7863
  • Author Web Link
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  • Citations: 280
• Journal article
  Diaz P, Benet-Buchholz J, Vilar R, White AJPet al., 2006,

  Anion influence on the structures of a series of copper(II) metal-organic frameworks

  , INORGANIC CHEMISTRY, Vol: 45, Pages: 1617-1626, ISSN: 0020-1669
  • Author Web Link
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  • Citations: 125
• Journal article
  Miller PW, Long NJ, de Mello AJ, Vilar R, Passchier J, Gee Aet al., 2006,

  Rapid formation of amides via carbonylative coupling reactions using a microfluidic device

  , CHEMICAL COMMUNICATIONS, Pages: 546-548, ISSN: 1359-7345
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  • Citations: 83
• Conference paper
  Miller PW, Long NJ, De Mello AJ, Vilar R, Passchier J, Gee Aet al., 2006,

  Rapid gas-liquid palladium carbonylative cross-coupling reactions using a glass fabricated microfluidic chip for applications in ¹¹C- radiolabelling

  , Pages: 876-878

  A series of gas-liquid palladium catalysed carbonylative cross-coupling reactions, forming secondary amides, were carried out using a glass fabricated microfluidic device. Improved yields from the microreactions were obtained in short reaction times (< 2 min) and were higher in all cases when compared to their corresponding batch reactions. We are currently in the process of applying our reaction set-up to [11C]CO radiolabelling to be used in PET (Positron Emission Tomography) imaging. © 2006 Society for Chemistry and Micro-Nano Systems.

  • Abstract
  • Cite
  • Citations: 1
• Conference paper
  Reed JE, Arola A, Vilar R, Neidle Set al., 2005,

  Metal-containing stabilisers of G-quadruplex DNA as telomerase inhibitors.

  , 17th EORTC/AACR/NCI International Conference on Molecular Targets and Cancer Therapeutics, Publisher: AMER ASSOC CANCER RESEARCH, Pages: 9051S-9051S, ISSN: 1078-0432
  • Author Web Link
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• Journal article
  Owen GR, Burkill HA, Vilar R, White AJP, Williams DJet al., 2005,

  Palladium complexes containing ligands with hydrogen-bonding functionalities. Reactivity and catalytic studies with CO and olefins

  , Journal of Organometallic Chemistry, Vol: 690, Pages: 5113-5124, ISSN: 0022-328X
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• Journal article
  Formentin P, Gimeno N, Steinke JHG, Vilar Ret al., 2005,

  Reactivity of Grubbs' catalysts with urea- and amide-substituted olefins. Metathesis and isomerization

  , JOURNAL OF ORGANIC CHEMISTRY, Vol: 70, Pages: 8235-8238, ISSN: 0022-3263
  • Author Web Link
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  • Citations: 40
• Journal article
  Coronado E, Galan-Mascaros JR, Marti-Gastaldo C, Palomares E, Durrant JR, Vilar R, Gratzel M, Nazeeruddin MKet al., 2005,

  Reversible colorimetric probes for mercury sensing

  , JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 127, Pages: 12351-12356, ISSN: 0002-7863
  • Author Web Link
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  • Citations: 308
• Conference paper
  Rosivatz E, Vilar R, Woscholski R, 2005,

  Imaging of PKB phosphorylation as an in vivo readout for PTEN inhibition studies

  , IUBMB 50th Anniversary Symposium, Publisher: BLACKWELL PUBLISHING, Pages: 313-313, ISSN: 1742-464X
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• Journal article
  Burkill HA, Robertson NR, Vilar R, White AJP, Williams DJet al., 2005,

  Synthesis, structural characterization, and magnetic studies of polynuclear iron complexes with a new disubstituted pyridine ligand

  , INORGANIC CHEMISTRY, Vol: 44, Pages: 3337-3346, ISSN: 0020-1669
  • Author Web Link
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  • Citations: 23
• Journal article
  Christmann U, Vilar R, 2005,

  Monoligated palladium species as catalysts in cross-coupling reactions

  , ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 44, Pages: 366-374, ISSN: 1433-7851
  • Author Web Link
  • Cite
  • Citations: 678
• Journal article
  Tovilla JA, Vilar R, White AJP, 2005,

  A di-palladium urea complex as a molecular receptor for anions

  , CHEMICAL COMMUNICATIONS, Pages: 4839-4841, ISSN: 1359-7345
  • Author Web Link
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  • Citations: 24
• Journal article
  Diaz P, Mingos DMP, Vilar R, White AJP, Williams DJet al., 2004,

  Anion-templated synthesis of metallacages as a means for the colorimetric detection of chlorides

  , INORGANIC CHEMISTRY, Vol: 43, Pages: 7597-7604, ISSN: 0020-1669
  • Author Web Link
  • Cite
  • Citations: 54
• Journal article
  Christmann U, Vilar R, White AJP, Williams DJet al., 2004,

  Synthesis of two novel dinuclear palladium(I) complexes and studies of their catalytic activity in amination reactions

  , CHEMICAL COMMUNICATIONS, Pages: 1294-1295, ISSN: 1359-7345
  • Author Web Link
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  • Citations: 74
• Journal article
  Schmid AC, Byrne RD, Vilar R, Woscholski Ret al., 2004,

  Bisperoxovanadium compounds are potent PTEN inhibitors

  , FEBS LETTERS, Vol: 566, Pages: 35-38, ISSN: 1873-3468
  • Author Web Link
  • Cite
  • Citations: 173
• Journal article
  Rais D, Gould IR, Vilar R, White AJP, Williams DJet al., 2004,

  Structural and theoretical studies of new ruthenium-amidato complexes with phenanthroline ligands containing H-bonding groups

  , EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Pages: 1865-1872, ISSN: 1434-1948
  • Author Web Link
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  • Citations: 9
• Journal article
  Palomares E, Vilar R, Durrant JR, 2004,

  Heterogeneous colorimetric sensor for mercuric salts

  , CHEMICAL COMMUNICATIONS, Pages: 362-363, ISSN: 1359-7345
  • Author Web Link
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  • Citations: 158

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