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• Conference paper
  Sala R, Quang-De N, Patel C, Mann D, Steinke JHG, Vilar R, Aboagye EOet al., 2013,

  Regulation of 18F-fluorothymidine uptake by thymidine kinase 1 protein phosphorylation.

  , 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
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• Journal article
  Zhou W, Suntharalingam K, Brand NJ, Barton PJR, Vilar R, Ying Let al., 2013,

  Possible Regulatory Roles of Promoter G-Quadruplexes in Cardiac Function-Related Genes - Human TnIc as a Model

  , PLOS One, Vol: 8, ISSN: 1932-6203

  G-quadruplexes (G4s) are four-stranded DNA secondary structures, which are involved in a diverse range of biological processes. Although the anti-cancer potential of G4s in oncogene promoters has been thoroughly investigated, the functions of promoter G4s in non-cancer-related genes are not well understood. We have explored the possible regulatory roles of promoter G4s in cardiac function-related genes using both computational and a wide range of experimental approaches. According to our bioinformatics results, it was found that potential G4-forming sequences are particularly enriched in the transcription regulatory regions (TRRs) of cardiac function-related genes. Subsequently, the promoter of human cardiac troponin I (TnIc) was chosen as a model, and G4s found in this region were subjected to biophysical characterisations. The chromosome 19 specific minisatellite G4 sequence (MNSG4) and near transcription start site (TSS) G4 sequence (−80 G4) adopt anti-parallel and parallel structures respectively in 100 mM KCl, with stabilities comparable to those of oncogene G4s. It was also found that TnIc G4s act cooperatively as enhancers in gene expression regulation in HEK293 cells, when stabilised by a synthetic G4-binding ligand. This study provides the first evidence of the biological significance of promoter G4s in cardiac function-related genes. The feasibility of using a single ligand to target multiple G4s in a particular gene has also been discussed.

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• Book chapter
  Mann DJ, Vilar R, 2013,

  Platinum(II) Complexes, Inhibition of Kinases

  , Encyclopedia of Metalloproteins, Pages: 1729-1733
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• Journal article
  Ghosh S, Silber GT, White AJP, Robertson N, Vilar Ret al., 2013,

  Synthesis of a self-assembled copper(II) metallo-rectangle with a guanosine-substituted terpyridine

  , DALTON TRANSACTIONS, Vol: 42, Pages: 13813-13816, ISSN: 1477-9226
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  • Citations: 8
• Journal article
  Leczkowska A, Vilar R, 2013,

  Interaction of metal complexes with nucleic acids

  , ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 109, Vol: 109, Pages: 299-316, ISSN: 0260-1818
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  • Citations: 13
• Book chapter
  Suntharalingam K, Vilar R, 2013,

  RECOGNITION OF G-QUADRUPLEXES BY METAL COMPLEXES

  , GUANINE QUARTETS: STRUCTURE AND APPLICATION, Editors: Spindler, Fritzsche, Publisher: ROYAL SOC CHEMISTRY, Pages: 263-274, ISBN: 978-1-84973-460-8
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  • Citations: 1
• Journal article
  Suntharalingam K, Mendoza O, Duarte AA, Mann DJ, Vilar Ret al., 2013,

  A platinum complex that binds non-covalently to DNA and induces cell death <i>via</i> a different mechanism than cisplatin

  , METALLOMICS, Vol: 5, Pages: 514-523, ISSN: 1756-5901
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  • Citations: 86
• Journal article
  Jimeno C, Christmann U, Escudero-Adan EC, Vilar R, Pericas MAet al., 2012,

  Studies on the Amination of Aryl Chlorides with a Monoligated Palladium Catalyst: Kinetic Evidence for a Cooperative Mechanism

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 16510-16516, ISSN: 0947-6539
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  • Citations: 19
• Journal article
  Suntharalingam K, Leczkowska A, Furrer MA, Wu Y, Kuimova MK, Therrien B, White AJP, Vilar Ret al., 2012,

  A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 16277-16282, ISSN: 0947-6539
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  • Citations: 53
• Journal article
  Suntharalingam K, Hunt DJ, Duarte AA, White AJP, Mann DJ, Vilar Ret al., 2012,

  A Tri-copper(II) Complex Displaying DNA-Cleaving Properties and Antiproliferative Activity against Cancer Cells

  , CHEMISTRY-A EUROPEAN JOURNAL, Vol: 18, Pages: 15133-15141, ISSN: 0947-6539
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  • Citations: 70
• Journal article
  Tate CW, Gee AD, Vilar R, White AJP, Long NJet al., 2012,

  Reversible carbon monoxide binding at copper(I) P-S-X (<i>X</i>=N, O) coordination polymers

  , JOURNAL OF ORGANOMETALLIC CHEMISTRY, Vol: 715, Pages: 39-42, ISSN: 0022-328X
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  • Citations: 1
• Journal article
  Herranz F, Schmidt-Weber CB, Shamji MH, Narkus A, Ruiz-Cabello J, Vilar Ret al., 2012,

  Superparamagnetic iron oxide nanoparticles conjugated to a grass pollen allergen and an optical probe

  , CONTRAST MEDIA & MOLECULAR IMAGING, Vol: 7, Pages: 435-439, ISSN: 1555-4309
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  • Citations: 7
• Journal article
  Campbell NH, Abd Karim NH, Parkinson GN, Gunaratnam M, Petrucci V, Todd AK, Vilar R, Neidle Set al., 2012,

  Molecular Basis of Structure-Activity Relationships between Salphen Metal Complexes and Human Telomeric DNA Quadruplexes

  , JOURNAL OF MEDICINAL CHEMISTRY, Vol: 55, Pages: 209-222, ISSN: 0022-2623
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  • Citations: 200
• Journal article
  Marti-Centelles V, Isabel Burguete M, Galindo F, Angeles Izquierdo M, Kumar DK, White AJP, Luis SV, Vilar Ret al., 2012,

  Fluorescent Acridine-Based Receptors for H₂PO₄<SUP>-</SUP>

  , JOURNAL OF ORGANIC CHEMISTRY, Vol: 77, Pages: 490-500, ISSN: 0022-3263
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  • Citations: 55
• Journal article
  Gong X, Miller PW, Gee AD, Long NJ, deMello AJ, Vilar Ret al., 2012,

  Gas–Liquid Segmented Flow Microfluidics for Screening Pd-Catalyzed Carbonylation Reactions

  , Chemistry: A European Journal, Vol: 18, Pages: 2768-2772
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• Journal article
  Tate CW, deMello A, Gee AD, Kealey S, Vilar R, White AJP, Long NJet al., 2012,

  Hemilabile and reversible carbon monoxide binding properties of iron(II), cobalt(II) and nickel(II) complexes containing a new tridentate P-S-N ligand

  , DALTON TRANSACTIONS, Vol: 41, Pages: 83-89, ISSN: 1477-9226
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  • Citations: 12
• Journal article
  Leczkowska A, Vilar R, 2012,

  Interaction of metal complexes with nucleic acids

  , ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 108, Vol: 108, Pages: 330-349, ISSN: 0260-1818
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  • Citations: 8
• Journal article
  Child ES, Georgiades SN, Rose KN, Stafford VS, Patel CBK, Steinke JHG, Mann DJ, Vilar Ret al., 2011,

  Inhibition of mitogen-activated protein kinase (MAPK) and cyclin-dependent kinase 2 (Cdk2) by platinum(II) phenanthroline complexes.

  , J Chem Biol, Vol: 4, Pages: 159-165

  UNLABELLED: Inhibition of protein kinases in the fight against disease remains a constant challenge for medicinal chemists, who have screened multitudes of predominantly planar organic scaffolds, natural and synthetic, to identify potent-albeit not always selective-kinase inhibitors. Herein, in an effort to investigate the potential biological utility of metal-based compounds as inhibitors against the cancer-relevant targets mitogen-activated protein kinase and cyclin-dependent kinase 2, we explore various parameters in planar platinum(II) complexes with substituted phenanthroline ligands and aliphatic diamine chelate co-ligands, to identify combinations that yield promising inhibitory activity. The individual ligands' steric requirements as well as their pattern of hydrogen bond donors/acceptors appear to alter inhibitory potency when modulated. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12154-011-0059-5) contains supplementary material, which is available to authorized users.

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• Journal article
  Mak LH, Georgiades SN, Rosivatz E, Whyte GF, Mirabelli M, Vilar R, Woscholski Ret al., 2011,

  A Small Molecule Mimicking a Phosphatidylinositol (4,5)-Bisphosphate Binding Pleckstrin Homology Domain

  , ACS Chemical Biology, ISSN: 1554-8929
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• Journal article
  Campbelll NH, Karim NHA, Parkinson GN, Vilar R, Neidie Set al., 2011,

  The first crystal structure of a telomeric quadruplex DNA with a metal containing ligand

  , CANCER RESEARCH, Vol: 71, ISSN: 0008-5472
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• Journal article
  Georgiades S, Mak L, Angurell I, Rosivatz E, Firouz Mohd Mustapa M, Polychroni C, Woscholski R, Vilar Ret al., 2011,

  Identification of a potent activator of Akt phosphorylation from a novel series of phenolic, picolinic, pyridino, and hydroxamic zinc(II) complexes

  , Journal of Biological Inorganic Chemistry, Vol: 16, Pages: 195-208, ISSN: 0949-8257
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• Journal article
  D'Arcy M, Weiss DJ, Bluck M, Vilar Ret al., 2011,

  Adsorption kinetics, capacity and mechanism of arsenate and phosphate on a bifunctional TiO2-Fe2O3 bi-composite

  , Journal of Colloid and Interface Science, Vol: 364, Pages: 205-212
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• Journal article
  Marti-Centelles V, Kumar DK, White AJP, Luis SV, Vilar Ret al., 2011,

  Zinc(ii) coordination polymers with pseudopeptidic ligands

  , CrystEngComm, Vol: 13, Pages: 6997-7008

  Two new phenyl-bridged pseudopeptidic ligands have been prepared and structurally characterised. The nature of the ligands' substituents play an important role in the nature of the solid state structure yielding either hydrogen bonded linked sheets of molecules or infinite hydrogen bonded networks. Both these ligands were reacted with a range of zinc(ii) salts with the aim of synthesising coordination polymers and networks and exploring the role that anions could play in determining the final structure. The crystal structures of four of these systems (with ZnSO4 and ZnBr2) were determined; in one case, a 3D coordination network was obtained where zinc-ligand coordination bonds generated the 3D arrangements. Three other 3D networks were obtained by anion-mediated hydrogen bonding of coordination 1D chains or 2D sheets. These four very different structures highlight the important role played by the ligands' substituents and the counteranions present in the system.

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• Journal article
  Suntharalingam K, Vilar R, 2011,

  Interaction of metal complexes with nucleic acids

  , ANNUAL REPORTS ON THE PROGRESS OF CHEMISTRY, SECTION A: INORGANIC CHEMISTRY, VOL 107, Vol: 107, Pages: 339-358, ISSN: 0260-1818
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  • Citations: 9
• Journal article
  Buscemi G, Miller PW, Kealey S, Gee AD, Long NJ, Passchier J, Vilar Ret al., 2011,

  Rapid carbonylative coupling reactions using palladium(I) dimers: applications to <SUP>11</SUP>CO-radiolabelling for the synthesis of PET tracers

  , ORGANIC & BIOMOLECULAR CHEMISTRY, Vol: 9, Pages: 3499-3503, ISSN: 1477-0520
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  • Citations: 29
• Journal article
  Surman AJ, Bonnet CS, Lowe MP, Kenny GD, Bell JD, Toth E, Vilar Ret al., 2011,

  A Pyrophosphate-Responsive Gadolinium(III) MRI Contrast Agent

  , Chemistry - A European Journal, Vol: 17, Pages: 223-230, ISSN: 0947-6539
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• Journal article
  Miller PW, Audrain H, Bender D, deMello AJ, Gee AD, Long NJ, Vilar Ret al., 2011,

  Rapid Carbon-11 Radiolabelling for PET Using Microfluidics

  , Chemistry - A European Journal, Vol: 17, Pages: 460-463
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• Journal article
  Li X, Nazeeruddin MK, Thelakkat M, Barnes PRF, Vilar R, Durrant JRet al., 2011,

  Spectroelectrochemical studies of hole percolation on functionalised nanocrystalline TiO₂ films: a comparison of two different ruthenium complexes

  , PHYSICAL CHEMISTRY CHEMICAL PHYSICS, Vol: 13, Pages: 1575-1584, ISSN: 1463-9076
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  • Citations: 33
• Journal article
  Surman AJ, Kenny GD, Kumar DK, Bell JD, Casey DR, Vilar Ret al., 2011,

  Targeting of anionic membrane species by lanthanide(iii) complexes: towards improved MRI contrast agents for apoptosis

  , Chemical Communications, ISSN: 1359-7345
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• Journal article
  Mak L, Vilar R, Woscholski R, 2010,

  Characterisation of the PTEN inhibitor VO-OHpic

  , Journal of Chemical Biology, Vol: 3, Pages: 157-163, ISSN: 1864-6158
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