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  • Journal article
    Alqurashi T, Montelongo Y, Penchev P, Yetisen AK, Dimov S, Butt Het al., 2017,

    Femtosecond laser ablation of transparent microphotonic devices and computer-generated holograms

    , NANOSCALE, Vol: 9, Pages: 13808-13819, ISSN: 2040-3364
  • Conference paper
    Vega K, Jiang N, Liu X, Kan V, Barry N, Maes P, Yetisen A, Paradiso Jet al., 2017,

    The Dermal Abyss: Interfacing with the Skin by Tattooing Biosensors

    , ACM International Joint Conference on Pervasive and Ubiquitous Computing (UBICOMP) / ACM International Symposium on Wearable Computers (ISWC), Publisher: ASSOC COMPUTING MACHINERY, Pages: 138-145
  • Journal article
    Khalid MW, Ahmed R, Yetisen AK, AlQattan B, Butt Het al., 2017,

    Holographic writing of ink-based phase conjugate nanostructures via laser ablation

    , Scientific Reports, Vol: 7, ISSN: 2045-2322

    The optical phase conjugation (OPC) through photonic nanostructures in coherent optics involves the utilization of a nonlinear optical mechanism through real-time processing of electromagnetic fields. Their applications include spectroscopy, optical tomography, wavefront sensing, and imaging. The development of functional and personalized holographic devices in the visible and near-infrared spectrum can be improved by introducing cost-effective, rapid, and high-throughput fabrication techniques and low-cost recording media. Here, we develop flat and thin phase-conjugate nanostructures on low-cost ink coated glass substrates through a facile and flexible single pulsed nanosecond laser based reflection holography and a cornercube retroreflector (CCR). Fabricated one/two-dimensional (1D/2D) nanostructures exhibited far-field phase-conjugated patterns through wavefront reconstruction by means of diffraction. The optical phase conjugation property had correlation with the laser light (energy) and structural parameters (width, height and exposure angle) variation. The phase conjugated diffraction property from the recorded nanostructures was verified through spectral measurements, far-field diffraction experiments, and thermal imaging. Furthermore, a comparison between the conventional and phase-conjugated nanostructures showed two-fold increase in diffracted light intensity under monochromatic light illumination. It is anticipated that low-cost ink based holographic phase-conjugate nanostructures may have applications in flexible and printable displays, polarization-selective flat waveplates, and adaptive diffraction optics.

  • Journal article
    Dou Q, Hu D, Gao H, Zhang Y, Yetisen AK, Butt H, Wang J, Nie G, Dai Qet al., 2017,

    High performance boronic acid-containing hydrogel for biocompatible continuous glucose monitoring

    , RSC Advances: an international journal to further the chemical sciences, Vol: 7, Pages: 41384-41390, ISSN: 2046-2069

    Rapid and robust hydrogels are essential in realizing continuous glucose monitoring in diabetes monitoring. However, existing hydrogels are limited in satisfying all of the sensory requirements such as detection range, response time, recoverability and biocompatibility. Here, we have developed a surface-initiated polymerization method to chemically immobilize a nano-boronic acid-hydrogel membrane onto a quartz crystal, then used a quartz crystal microbalance (QCM) to achieve real-time monitoring of glucose. The experimental results show that this hydrogel possesses enhanced binding properties to glucose under physiological conditions (pH 7.0–7.5) and blood glucose concentration (BGC) (1.1–33.3 mM). Moreover, our hydrogel displayed a rapid response time (∼100 s) to glucose, high biocompatibility in vivo through an animal model. The hydrogel has a great potential as a sensitive glucose probe for implantable continuous glucose sensors.

  • Journal article
    Tamayol A, Najafabadi AH, Mostafalu P, Yetisen AK, Commotto M, Aldhahri M, Abdel-wahab MS, Najafabadi ZI, Latifi S, Akbari M, Annabi N, Yun SH, Memic A, Dokmeci MR, Khademhosseini Aet al., 2017,

    Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

    , SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

    The optical phase conjugation (OPC) through photonic nanostructures in coherent optics involves the utilization of a nonlinear optical mechanism through real-time processing of electromagnetic fields. Their applications include spectroscopy, optical tomography, wavefront sensing, and imaging. The development of functional and personalized holographic devices in the visible and near-infrared spectrum can be improved by introducing cost-effective, rapid, and high-throughput fabrication techniques and low-cost recording media. Here, we develop flat and thin phase-conjugate nanostructures on low-cost ink coated glass substrates through a facile and flexible single pulsed nanosecond laser based reflection holography and a cornercube retroreflector (CCR). Fabricated one/two-dimensional (1D/2D) nanostructures exhibited far-field phase-conjugated patterns through wavefront reconstruction by means of diffraction. The optical phase conjugation property had correlation with the laser light (energy) and structural parameters (width, height and exposure angle) variation. The phase conjugated diffraction property from the recorded nanostructures was verified through spectral measurements, far-field diffraction experiments, and thermal imaging. Furthermore, a comparison between the conventional and phase-conjugated nanostructures showed two-fold increase in diffracted light intensity under monochromatic light illumination. It is anticipated that low-cost ink based holographic phase-conjugate nanostructures may have applications in flexible and printable displays, polarization-selective flat waveplates, and adaptive diffraction optics.

  • Journal article
    Bentaleb EM, El Messaoudi MD, Abid M, Messaoudi M, Yetisen AK, Sefrioui H, Amzazi S, Benhassou HAet al., 2017,

    Plasmid-based high-resolution melting analysis for accurate detection of rpoB mutations in Mycobacterium tuberculosis isolates from Moroccan patients

    , BMC Infectious Diseases, Vol: 17, ISSN: 1471-2334

    BackgroundRapid diagnosis of drug resistance in tuberculosis (TB) is pivotal for the timely initiation of effective antibiotic treatment to prevent the spread of drug-resistant strains. The development of low-cost, rapid and robust methods for drug-resistant TB detection is highly desirable for resource-limited settings.MethodsWe report the use of an in house plasmid-based quantitative polymerase chain reaction-high-resolution melting (qPCR-HRM) analysis for the detection of mutations related to rifampicin-resistant Mycobacterium tuberculosis (MTB) in clinical isolates from Moroccan patients. Five recombinant plasmids containing predominant mutations (S531L, S531W, H526Y and D516V) and the wild-type sequence of the Rifampicin Resistance-Determining Region (RRDR) have been used as controls to screen 45 rifampicin-resistant and 22 rifampicin-susceptible MTB isolates.ResultsThe sensitivity and the specificity of the qPCR-HRM analysis were 88.8% and 100% respectively as compared to rifampicin Drug Susceptibility Testing (DST). The results of qPCR-HRM and DNA sequencing had a concordance of 100%.ConclusionOur qPCR-HRM assay is a sensitive, accurate and cost-effective assay for the high-throughput screening of mutation-based drug resistance in TB reference laboratories.

  • Patent
    Yetisen AK, Del Rossi J, Dunlop P, Schoonmaker S, Michael S, Sanchez Set al., 2011,

    Cell staining with air quenched steam heating

    , PCT/US2011/034824

    An automated cell staining apparatus comprises a chamber enclosing a microscope slide having a sample thereon, a steam heat source and an air source. The steam heat source is capable of heating the chamber, microscope slide and sample with steam to a desired temperature. The air source is capable of cooling the steam from the steam heat source with air for controllably reaching the desired temperature. In some embodiments, there is a temperature sensor for detecting the temperature and a controller programmed to cause the chamber to meet a desired set point temperature by supplying air and/or steam.

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