@article{Jiang:2020:10.1016/j.snb.2020.128378,
author = {Jiang, N and Yetisen, AK and Linhart, N and Flisikowski, K and Dong, J and Dong, X and Butt, H and Jakobi, M and Schnieke, A and Koch, AW},
doi = {10.1016/j.snb.2020.128378},
journal = {Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers},
title = {Fluorescent dermal tattoo biosensors for electrolyte analysis},
url = {http://dx.doi.org/10.1016/j.snb.2020.128378},
volume = {320},
year = {2020}
}

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TY  - JOUR
AB  - Dehydration, the abnormal depletion of body fluid, has been considered to greatly affect metabolic activities that may cause electrolyte disorder. However, current diagnostic approaches often fail to provide rapid and accurate electrolyte measurements in point-of-care settings. Here, fluorescent dermal tattoo sensors were developed to monitor electrolytes (e.g. H+, Na+, and K+ ions) in dermal interstitial fluids by using a customizable tattoo sensing platform. This platform consists of multiplexed fluorescent sensors including seminaphtorhodafluor, fluorescent diaza-15-crown-5 ether, and fluorescent diaza-18-crown-6 ether tattooed in the skin tissue. A portable optical readout device comprised of a smartphone, excitation light sources, and optical bandpass filters is developed to measure the fluorescence emission intensity of the tattoo sensors. The smartphone readout application features a user interface and a compensation algorithm to estimate electrolyte concentrations. Ex vivo studies in porcine skin tissues show that the tattooed sensors could provide quantitative results of electrolytes in dermis. These dermal sensors detect pH value, Na+ and K+ ions in the ranges of 6.6–7.6, 100−175mmol L−1, and 2.0–6.0mmol L−1. The detected emission intensities are converted to the concentration values of electrolytes and display in the smartphone diagnostic report. The dermal tattoo sensor may enable continual assessment of hydration status in point-of-care settings.
AU  - Jiang,N
AU  - Yetisen,AK
AU  - Linhart,N
AU  - Flisikowski,K
AU  - Dong,J
AU  - Dong,X
AU  - Butt,H
AU  - Jakobi,M
AU  - Schnieke,A
AU  - Koch,AW
DO  - 10.1016/j.snb.2020.128378
PY  - 2020///
SN  - 0925-4005
TI  - Fluorescent dermal tattoo biosensors for electrolyte analysis
T2  - Sensors and Actuators B: Chemical: international journal devoted to research and development of physical and chemical transducers
UR  - http://dx.doi.org/10.1016/j.snb.2020.128378
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000557929000013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0925400520307231?via%3Dihub
VL  - 320
ER  - 

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