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• Journal article
  Kamijo Y, Mächler P, Ness N, Vu CQ, Kusakizako T, Mannuthodikayil J, Ku Z, Boisvert M, Grebenik E, Miyazaki I, Hashizume R, Sato H, Liu R, Hori Y, Tomita T, Katayama T, Furube A, Caraveo G, Paquet M-E, Drobizhev M, Nureki O, Arai S, Brancaccio M, Campbell RE, Kleinfeld D, Nasu Yet al., 2025,

  Publisher Correction: A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics.

  , Nat Commun, Vol: 16
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• Journal article
  Kamijo Y, Machler P, Ness N, Vu CQ, Kusakizako T, Mannuthodikayil J, Ku Z, Boisvert M, Grebenik E, Miyazaki I, Hashizume R, Sato H, Liu R, Hori Y, Tomita T, Katayama T, Furube A, Caraveo G, Paquet M-E, Drobizhev M, Nureki O, Arai S, Brancaccio M, Campbell RE, Kleinfeld D, Nasu Yet al., 2025,

  A red fluorescent genetically encoded biosensor for in vivo imaging of extracellular l-lactate dynamics

  , NATURE COMMUNICATIONS, Vol: 16
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• Journal article
  Brancaccio M, 2025,

  Integrating Astrocytes in the Sleep-Wake Cycle: The Time Is Now

  , BIOESSAYS, ISSN: 0265-9247
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• Journal article
  Ness N, Diaz Clavero S, Hoekstra M, Brancaccio Met al., 2025,

  Astrocytic GABA produced from polyamines synchronizes neuronal circadian timekeeping in the suprachiasmatic nucleus

  , The EMBO Journal, Vol: 44, Pages: 356-381, ISSN: 0261-4189

  Astrocytes of the suprachiasmatic nucleus (SCN) can regulate sleep-wake cycles in mammals. However, the nature of the information provided by astrocytes to control circadian patterns of behavior is unclear. Neuronal circadian activity across the SCN is organized into spatiotemporal waves that govern seasonal adaptations and timely engagement of behavioral outputs. Here, we show that astrocytes across the mouse SCN exhibit instead a highly uniform, pulse-like nighttime activity. We find that rhythmic astrocytic GABA production via polyamine degradation provides an inhibitory nighttime tone required for SCN circuit synchrony, thereby acting as an internal astrocyte zeitgeber (or “astrozeit”). We further identify synaptic GABA and astrocytic GABA as two key players underpinning coherent spatiotemporal circadian patterns of SCN neuronal activity. In describing a new mechanism by which astrocytes contribute to circadian timekeeping, our work provides a general blueprint for understanding how astrocytes encode temporal information underlying complex behaviors in mammals.

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• Journal article
  Ness N, Diaz Clavero S, Hoekstra M, Brancaccio Met al., 2024,

  Rhythmic astrocytic GABA production synchronizesneuronal circadian timekeeping in thesuprachiasmatic nucleus

  , The EMBO Journal, ISSN: 0261-4189
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• Journal article
  Ness N, Brancaccio M, 2024,

  Network-level time computations in the suprachiasmatic nucleus

  , Cell Research, Vol: 34, Pages: 471-472, ISSN: 1001-0602

  Deciphering neuronal circuit dynamics is critical for understanding how the brain encodes information. In a recent study in Cell Research, Wang et al. shed light on how neuronal ensemble activity encodes time in the suprachiasmatic nucleus, and demonstrate the transformative potential of machine learning to decode complex neural processes.

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• Journal article
  Hoekstra M, Ness N, Badia Soteras A, Brancaccio Met al., 2024,

  Bmal1 integrates circadian function and temperature sensing in the suprachiasmatic nucleus

  , Proceedings of the National Academy of Sciences of USA, Vol: 121, ISSN: 0027-8424

  Circadian regulation and temperature dependency are important orchestrators of molecular pathways. How the integration between these two drivers is achieved, is not understood. We monitored circadian- and temperature-dependent effects on transcription dynamics of cold-response protein RNA Binding Motif 3 (Rbm3). Temperature changes in the mammalian master circadian pacemaker, the suprachiasmatic nucleus (SCN), induced Rbm3 transcription and regulated its circadian periodicity, whereas the core clock gene Per2 was unaffected. Rbm3 induction depended on a full Brain And Muscle ARNT-Like Protein 1 (Bmal1) complement: reduced Bmal1 erased Rbm3 responses and weakened SCN circuit resilience to temperature changes. By focusing on circadian and temperature dependency, we highlight weakened transmission between core clock and downstream pathways as a potential route for reduced circadian resilience.

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• Journal article
  De Virgiliis F, Mueller F, Palmisano I, Chadwick JS, Luengo-Gutierrez L, Giarrizzo A, Yan Y, Danzi MC, Picon-Munoz C, Zhou L, Kong G, Serger E, Hutson TH, Maldonado-Lasuncion I, Song Y, Scheiermann C, Brancaccio M, Di Giovanni Set al., 2023,

  The circadian clock time tunes axonal regeneration

  , CELL METABOLISM, Vol: 35, Pages: 2153-+, ISSN: 1550-4131
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• Journal article
  Hastings MH, Brancaccio M, Gonzalez-Aponte MF, Herzog EDet al., 2023,

  Circadian rhythms and astrocytes: the good, the bad, and the ugly

  , Annual Review of Neuroscience, Vol: 46, Pages: 123-143, ISSN: 0147-006X

  This review explores the interface between circadian timekeeping and the regulation of brain function by astrocytes. Although astrocytes regulate neuronal activity across many time domains, their cell-autonomous circadian clocks exert a particular role in controlling longer-term oscillations of brain function: the maintenance of sleep states and the circadian ordering of sleep and wakefulness. This is most evident in the central circadian pacemaker, the suprachiasmatic nucleus, where the molecular clock of astrocytes suffices to drive daily cycles of neuronal activity and behavior. In Alzheimer's disease, sleep impairments accompany cognitive decline. In mouse models of the disease, circadian disturbances accelerate astroglial activation and other brain pathologies, suggesting that daily functions in astrocytes protect neuronal homeostasis. In brain cancer, treatment in the morning has been associated with prolonged survival, and gliomas have daily rhythms in gene expression and drug sensitivity. Thus, circadian time is fast becoming critical to elucidating reciprocal astrocytic-neuronal interactions in health and disease. Expected final online publication date for the Annual Review of Neuroscience, Volume 46 is July 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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• Journal article
  Brancaccio M, 2022,

  Glia-neuron interplay drivescircadian glycosphingolipid homeostasisand structural brain plasticity

  , NEURON, Vol: 110, Pages: 3058-3060, ISSN: 0896-6273
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