Aortic archImage credit - Professor Dorian Haskard


Recent publications from 2018

Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta.

A. Y. F. You, M. S. Bergholt, J.-P. St. Pierre, W. Kit-anan, I. J. Pence, A. H. Chester, M. H. Yacoub, S. Bertazzo, M. M. Stevens. Science Advances. 2017. 3(12): e1701156.

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.

Biffi C, de Marvao A, Attard MI, Dawes TJW, Whiffin N, Bai W, Shi W, Francis C, Meyer H, Buchan R, Cook SA, Rueckert D, O'Regan DP. Bioinformatics 2018;34(1):97-103. 

Aortic Dilatation in Repaired Tetralogy of Fallot. JACC Cardiovasc Imaging.

Bonello B, Shore DF, Uebing A, Diller GP, Keegan J, Burman ED, Shiina Y, Swan L, Pennell DJ, Kilner PJ, Beurtheret S, Gatzoulis MA, Babu-Narayan SV. 2018 Jan;11(1):150-152. doi: 10.1016/j.jcmg.2017.01.021. Epub 2017 Apr 12. PubMed PMID: 28412425. 

Anomalous drainage of isolated superior caval vein to the left atrium: the oldest reported unrepaired case.

Boutsikou M, Pennell DJ, Nyktari E. Cardiol Young. 2017 Jul;27(5):1008-1010. doi: 10.1017/S1047951116002808. Epub 2017 Feb 15. PubMed PMID: 28196557.

Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot.

Cauldwell M, Quail MA, Smith GS, Heng EL, Ghonim S, Uebing A, Swan L, Li W, Patel RR, Pennell DJ, Steer PJ, Johnson MR, Gatzoulis MA, Babu-Narayan SV. J Am Heart Assoc. 2017 Jul 23;6(7). pii: e005420. doi: 10.1161/JAHA.116.005420. PubMed PMID: 28736387; PubMed Central PMCID: PMC5586280.

Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. (In review)

Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont.

Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. (In review).

Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont.

Evaluation of the impact of strain correction on the orientation of cardiac diffusion tensors with in vivo and ex vivo porcine hearts.

Ferreira PF, Nielles-Vallespin S, Scott AD, de Silva R, Kilner PJ, Ennis DB, Auger DA, Suever JD, Zhong X, Spottiswoode BS, Pennell DJ, Arai AE, Firmin DN. Magn Reson Med. 2018 Apr;79(4):2205-2215. doi: 10.1002/mrm.26850. Epub 2017 Jul 21. PubMed PMID: 28734017; PubMed Central PMCID: PMC5776058.

Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs.

Fujita J, Freire P, Coarfa C, Benham AL, Gunaratne P, Schneider MD, Dejosez M, Zwaka TP. Cell Rep. 2017 Nov 7;21(6):1562-1573. doi: 10.1016/j.celrep.2017.10.036. PubMed PMID: 29117561; PubMed Central PMCID: PMC5695914.

Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow.

Ghim M, Alpresa P, Yang SW, Braakman ST, Gray SG, Sherwin SJ, van Reeuwijk M, Weinberg PD. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H959-H973.

Diffusion tensor cardiovascular magnetic resonance with a spiral trajectory:  An in vivo comparison of echo planar and spiral stimulated echo sequences.

Gorodezky M, Scott AD, Ferreira PF, Nielles-Vallespin S, Pennell DJ, Firmin DN. Magn Reson Med. 2017 Dec 19. doi: 10.1002/mrm.27051. [Epub ahead of print] PubMed PMID: 29266435.

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and  Mild and Moderate Left Ventricular Systolic Dysfunction.

Halliday BP, Gulati A, Ali A, Guha K, Newsome S, Arzanauskaite M, Vassiliou VS, Lota A, Izgi C, Tayal U, Khalique Z, Stirrat C, Auger D, Pareek N, Ismail TF, Rosen SD, Vazir A, Alpendurada F, Gregson J, Frenneaux MP, Cowie MR, Cleland JGF, Cook SA, Pennell DJ, Prasad SK. Circulation. 2017 May 30;135(22):2106-2115. doi: 10.1161/CIRCULATIONAHA.116.026910. Epub 2017 Mar 28. PubMed PMID: 28351901; PubMed Central PMCID: PMC5444425.

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction

Halliday BP, Pennell DJ, Prasad SK. Response by Halliday et al to Letter Regarding Article. Circulation. 2018 Jan 2;137(1):101-102. doi: 10.1161/CIRCULATIONAHA.117.032053. PubMed PMID: 29279345.

Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study.

Heng EL, Gatzoulis MA, Uebing A, Sethia B, Uemura H, Smith GC, Diller GP, McCarthy KP, Ho SY, Li W, Wright P, Spadotto V, Kilner PJ, Oldershaw P, Pennell, DJ, Shore DF, Babu-Narayan SV. Circulation.  2017 Oct 31;136(18):1703-1713. doi: 10.1161/CIRCULATIONAHA.117.027402. PubMed PMID: 29084778; PubMed Central PMCID: PMC5662153.

Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance.

Khalique Z, Ferreira PF, Scott AD, Nielles-Vallespin S, Kilner PJ, Kutys R, Romero M, Arai AE, Firmin DN, Pennell DJ. JACC Cardiovasc Imaging. 2018 Jan 12. pii: S1936-878X(17)31083-5. doi: 10.1016/j.jcmg.2017.11.014. [Epub ahead of print] PubMed PMID: 29361490.

Apheresis as novel treatment for refractory angina with raised lipoprotein(a): a randomized controlled cross-over trial.

Khan TZ, Hsu LY, Arai AE, Rhodes S, Pottle A, Wage R, Banya W, Gatehouse PD,  Giri S, Collins P, Pennell DJ, Barbir M. Eur Heart J. 2017 May 21;38(20):1561-1569. doi: 10.1093/eurheartj/ehx178.  PubMed PMID: 28453721.

What is CMR doing for patients today? 

Khalique Z, Pennell DJ. Eur Heart J. 2018 Jan 21;39(4):266-270. doi: 10.1093/eurheartj/ehx778. PubMed PMID: 29365112.

Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia.

Kirk P, Sheppard M, Carpenter JP, Anderson L, He T, St Pierre T, Galanello R, Catani G, Wood J, Fucharoen S, Porter JB, Walker JM, Forni GL, Pennell DJ. J Cardiovasc Magn Reson. 2017 Mar 27;19(1):36. doi: 10.1186/s12968-017-0349-3. PubMed PMID: 28343449; PubMed Central PMCID: PMC5367003.

Late Anthracycline-Related Cardiotoxicity in Low-Risk Breast Cancer Patients.

Maestrini V, Cheang MH, Kotwinski P, Rosmini S, Lloyd G, Kellman P, Pennell DJ, Montgomery H, Moon JC, Manisty C. J Am Coll Cardiol. 2017 May 23;69(20):2573-2575. doi: 10.1016/j.jacc.2017.03.560. PubMed PMID: 28521895.

ORCA-3 For the Optimal Restoration of Cardiac Activity (ORCA) Group. A feasibility and safety study of intracoronary hemodilution during primary coronary angioplasty in order to reduce reperfusion injury in myocardial infarction.

McGarvey M, Ali O, Iqbal MB, Ilsley C, Wong J, Di Mario C, Redwood S, Patterson T, Pennell DJ, Rogers P, Dalby M; Catheter Cardiovasc Interv. 2018 Feb 1;91(2):234-241. doi: 10.1002/ccd.27136. Epub 2017 Jun 21. PubMed PMID: 28636165.

Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices.

Rasheda A. Chowdhury, Konstantinos N. Tzortzis, Emmanuel Dupont, Shaun Selvadurai, Filippo Perbellini, Chris D. Cantwell, Fu SIong Ng, Andre R. Simon, Cesare M. Terracciano, Nicholas S. Peters. Scientific Reports (in press)

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis.

Roca-Alonso, L., Castellano, L., Mills, A., Dabrowska, A.F., Sikkel, M.B., Pellegrino, L., Jacob, J., Frampton, A.E., Krell, J., Coombes, R.C. and Harding, S.E., 2015. Cell death & disease6(5), p.e1754.

Major adverse events and atrial tachycardia in Ebstein's anomaly predicted by cardiovascular magnetic resonance.

Rydman R, Shiina Y, Diller GP, Niwa K, Li W, Uemura H, Uebing A, Barbero U, Bouzas B, Ernst S, Wong T, Pennell DJ, Gatzoulis MA, Babu-Narayan SV. Heart. 2018 Jan;104(1):37-44. doi: 10.1136/heartjnl-2017-311274. Epub 2017 Jul 6. PubMed PMID: 28684436; PubMed Central PMCID: PMC5749347.

Titin-truncating variants affect heart function in disease cohorts and the general population.

Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA. Nat Genet 2017;49(1):46-53.

Upstairs, Downstairs: Atrial and Ventricular Cardiac Myocytes from Human Pluripotent Stem Cells.

Schneider MD. Cell Stem Cell. 2017 Aug 3;21(2):151-152. doi: 10.1016/j.stem.2017.07.006.

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.

Schobesberger, S., Wright, P., Tokar, S., Bhargava, A., Mansfield, C., Glukhov, A.V., Poulet, C., Buzuk, A., Monszpart, A., Sikkel, M. and Harding, S.E., 2017. Cardiovascular research113(7), pp.770-782.

An in-vivo comparison of stimulated-echo and motion compensated spin-echo sequences for 3 T diffusion tensor cardiovascular magnetic  resonance at multiple cardiac phases.

Scott AD, Nielles-Vallespin S, Ferreira PF, Khalique Z, Gatehouse PD, Kilner P, Pennell DJ, Firmin DN. J Cardiovasc Magn Reson. 2018 Jan 3;20(1):1. doi: 10.1186/s12968-017-0425-8. PubMed PMID: 29298692; PubMed Central  PMCID: PMC5753538.

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.

Seneviratne, A.N., Edsfeldt, A.O., Cole, J.E., Kassiteridi, C., Swart, M., Park, I., Green, P., Khoyratty, T.E., Saliba, D.G., Goddard, M.E. and Sansom, S.N., 2017. Circulation, pp.CIRCULATIONAHA-117.

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.

Sheehan, A., Messer, A.E., Papadaki, M., Choudhry, A., Kren, V., Biedermann, D., Blagg, B., Khandelwal, A. and Marston, S.B., 2018. Frontiers in Physiology9, p.243.

Multimodal Hydrogel-Based Platform To Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM. ACS Cent Sci. 2017 Apr 26;3(4):338-348. doi: 10.1021/acscentsci.7b00039. Epub 2017 Mar 30.

Multimodal Hydrogel-Based Platform to Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM (2017). ACS Central Science. March 30 2017.

Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance.

Vassiliou VS, Flynn PD, Raphael CE, Newsome S, Khan T, Ali A, Halliday B, Studer Bruengger A, Malley T, Sharma P, Selvendran S, Aggarwal N, Sri A, Berry H, Donovan J, Lam W, Auger D, Cook SA, Pennell DJ, Prasad SK. PLoS One. 2017 Jul 13;12(7):e0181077. doi: 10.1371/journal.pone.0181077. eCollection 2017. PubMed PMID: 28704465; PubMed Central PMCID: PMC5509300.

Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis.

Vassiliou VS, Perperoglou A, Raphael CE, Joshi S, Malley T, Everett R, Halliday B, Pennell DJ, Dweck MR, Prasad SK. J Am Coll Cardiol. 2017 Apr 4;69(13):1755-1756. doi: 10.1016/j.jacc.2017.01.034. PubMed PMID: 28359524.

Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T (1) mapping: averaging to improve precision and correlation with collagen volume fraction.

Vassiliou VS, Wassilew K, Cameron D, Heng EL, Nyktari E, Asimakopoulos G, de  Souza A, Giri S, Pierce I, Jabbour A, Firmin D, Frenneaux M, Gatehouse P, Pennell DJ, Prasad SK. MAGMA. 2018 Feb;31(1):101-113. doi: 10.1007/s10334-017-0630-3. Epub 2017 Jun 12. PubMed PMID: 28608326; PubMed Central PMCID: PMC5813064.

Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging.

Wahidiyat PA, Liauw F, Sekarsari D, Putriasih SA, Berdoukas V, Pennell DJ. Hematology. 2017 Sep;22(8):501-507. doi: 10.1080/10245332.2017.1292614. Epub 2017 Feb 20. PubMed PMID: 28218005.

Raman spectroscopy imaging reveals interplay between atherosclerosis and medial calcification in human aorta.

A. Y. F. You, M. S. Bergholt, J.-P. St. Pierre, W. Kit-anan, I. J. Pence, A. H. Chester, M. H. Yacoub, S. Bertazzo, M. M. Stevens. Science Advances. 2017. 3(12): e1701156.

Three-dimensional cardiovascular imaging-genetics: a mass univariate framework.

Biffi C, de Marvao A, Attard MI, Dawes TJW, Whiffin N, Bai W, Shi W, Francis C, Meyer H, Buchan R, Cook SA, Rueckert D, O'Regan DP. Bioinformatics 2018;34(1):97-103.

Aortic Dilatation in Repaired Tetralogy of Fallot. JACC Cardiovasc Imaging.

Bonello B, Shore DF, Uebing A, Diller GP, Keegan J, Burman ED, Shiina Y, Swan L, Pennell DJ, Kilner PJ, Beurtheret S, Gatzoulis MA, Babu-Narayan SV. 2018 Jan;11(1):150-152. doi: 10.1016/j.jcmg.2017.01.021. Epub 2017 Apr 12. PubMed PMID: 28412425.

Anomalous drainage of isolated superior caval vein to the left atrium: the oldest reported unrepaired case.

Boutsikou M, Pennell DJ, Nyktari E. Cardiol Young. 2017 Jul;27(5):1008-1010. doi: 10.1017/S1047951116002808. Epub 2017 Feb 15. PubMed PMID: 28196557.

Effect of Pregnancy on Ventricular and Aortic Dimensions in Repaired Tetralogy of Fallot.

Cauldwell M, Quail MA, Smith GS, Heng EL, Ghonim S, Uebing A, Swan L, Li W, Patel RR, Pennell DJ, Steer PJ, Johnson MR, Gatzoulis MA, Babu-Narayan SV. J Am Heart Assoc. 2017 Jul 23;6(7). pii: e005420. doi: 10.1161/JAHA.116.005420. PubMed PMID: 28736387; PubMed Central PMCID: PMC5586280.

Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. (In review)

Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont.

Characterisation of re-entrant circuit (or rotational activity) in vitro using the HL1-6 myocyte cell line. (In review).

Charles Houston, Konstantinos N Tzortzis, Caroline Roney, Andrea Saglietto, David S Pitcher, Chris Cantwell, Rasheda A Chowdhury, Fu Siong Ng, Nicholas S Peters, Emmanuel Dupont.

Evaluation of the impact of strain correction on the orientation of cardiac diffusion tensors with in vivo and ex vivo porcine hearts.

Ferreira PF, Nielles-Vallespin S, Scott AD, de Silva R, Kilner PJ, Ennis DB, Auger DA, Suever JD, Zhong X, Spottiswoode BS, Pennell DJ, Arai AE, Firmin DN. Magn Reson Med. 2018 Apr;79(4):2205-2215. doi: 10.1002/mrm.26850. Epub 2017 Jul 21. PubMed PMID: 28734017; PubMed Central PMCID: PMC5776058.

Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs.

Fujita J, Freire P, Coarfa C, Benham AL, Gunaratne P, Schneider MD, Dejosez M, Zwaka TP. Cell Rep. 2017 Nov 7;21(6):1562-1573. doi: 10.1016/j.celrep.2017.10.036. PubMed PMID: 29117561; PubMed Central PMCID: PMC5695914.

Visualization of three pathways for macromolecule transport across cultured endothelium and their modification by flow.

Ghim M, Alpresa P, Yang SW, Braakman ST, Gray SG, Sherwin SJ, van Reeuwijk M, Weinberg PD. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H959-H973.

Diffusion tensor cardiovascular magnetic resonance with a spiral trajectory:  An in vivo comparison of echo planar and spiral stimulated echo sequences.

Gorodezky M, Scott AD, Ferreira PF, Nielles-Vallespin S, Pennell DJ, Firmin DN. Magn Reson Med. 2017 Dec 19. doi: 10.1002/mrm.27051. [Epub ahead of print] PubMed PMID: 29266435.

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients With Dilated Cardiomyopathy and  Mild and Moderate Left Ventricular Systolic Dysfunction.

Halliday BP, Gulati A, Ali A, Guha K, Newsome S, Arzanauskaite M, Vassiliou VS, Lota A, Izgi C, Tayal U, Khalique Z, Stirrat C, Auger D, Pareek N, Ismail TF, Rosen SD, Vazir A, Alpendurada F, Gregson J, Frenneaux MP, Cowie MR, Cleland JGF, Cook SA, Pennell DJ, Prasad SK. Circulation. 2017 May 30;135(22):2106-2115. doi: 10.1161/CIRCULATIONAHA.116.026910. Epub 2017 Mar 28. PubMed PMID: 28351901; PubMed Central PMCID: PMC5444425.

Association Between Midwall Late Gadolinium Enhancement and Sudden Cardiac Death in Patients with Dilated Cardiomyopathy and Mild and Moderate Left Ventricular Systolic Dysfunction

Halliday BP, Pennell DJ, Prasad SK. Response by Halliday et al to Letter Regarding Article. Circulation. 2018 Jan 2;137(1):101-102. doi: 10.1161/CIRCULATIONAHA.117.032053. PubMed PMID: 29279345.

Immediate and Midterm Cardiac Remodeling After Surgical Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot: A Prospective Cardiovascular Magnetic Resonance and Clinical Study.

Heng EL, Gatzoulis MA, Uebing A, Sethia B, Uemura H, Smith GC, Diller GP, McCarthy KP, Ho SY, Li W, Wright P, Spadotto V, Kilner PJ, Oldershaw P, Pennell, DJ, Shore DF, Babu-Narayan SV. Circulation.  2017 Oct 31;136(18):1703-1713. doi: 10.1161/CIRCULATIONAHA.117.027402. PubMed PMID: 29084778; PubMed Central PMCID: PMC5662153.

Deranged Myocyte Microstructure in Situs Inversus Totalis Demonstrated by Diffusion Tensor Cardiac Magnetic Resonance.

Khalique Z, Ferreira PF, Scott AD, Nielles-Vallespin S, Kilner PJ, Kutys R, Romero M, Arai AE, Firmin DN, Pennell DJ. JACC Cardiovasc Imaging. 2018 Jan 12. pii: S1936-878X(17)31083-5. doi: 10.1016/j.jcmg.2017.11.014. [Epub ahead of print] PubMed PMID: 29361490.

What is CMR doing for patients today?

Khalique Z, Pennell DJ. Eur Heart J. 2018 Jan 21;39(4):266-270. doi: 10.1093/eurheartj/ehx778. PubMed PMID: 29365112.

Apheresis as novel treatment for refractory angina with raised lipoprotein(a): a randomized controlled cross-over  trial.

Khan TZ, Hsu LY, Arai AE, Rhodes S, Pottle A, Wage R, Banya W, Gatehouse PD,  Giri S, Collins P, Pennell DJ, Barbir M. Eur Heart J. 2017 May 21;38(20):1561-1569. doi: 10.1093/eurheartj/ehx178.  PubMed PMID: 28453721.

Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia.

Kirk P, Sheppard M, Carpenter JP, Anderson L, He T, St Pierre T, Galanello R, Catani G, Wood J, Fucharoen S, Porter JB, Walker JM, Forni GL, Pennell DJ. J Cardiovasc Magn Reson. 2017 Mar 27;19(1):36. doi: 10.1186/s12968-017-0349-3. PubMed PMID: 28343449; PubMed Central PMCID: PMC5367003.

Late Anthracycline-Related Cardiotoxicity in Low-Risk Breast Cancer Patients.

Maestrini V, Cheang MH, Kotwinski P, Rosmini S, Lloyd G, Kellman P, Pennell DJ, Montgomery H, Moon JC, Manisty C. J Am Coll Cardiol. 2017 May 23;69(20):2573-2575. doi: 10.1016/j.jacc.2017.03.560. PubMed PMID: 28521895.

ORCA-3 For the Optimal Restoration of Cardiac Activity (ORCA) Group. A feasibility and safety study of intracoronary hemodilution during primary coronary angioplasty in order to reduce reperfusion injury in myocardial infarction.

McGarvey M, Ali O, Iqbal MB, Ilsley C, Wong J, Di Mario C, Redwood S, Patterson T, Pennell DJ, Rogers P, Dalby M; Catheter Cardiovasc Interv. 2018 Feb 1;91(2):234-241. doi: 10.1002/ccd.27136. Epub 2017 Jun 21. PubMed PMID: 28636165.

Concurrent micro- to macro-cardiac electrophysiology in myocyte cultures and human heart slices.

Rasheda A. Chowdhury, Konstantinos N. Tzortzis, Emmanuel Dupont, Shaun Selvadurai, Filippo Perbellini, Chris D. Cantwell, Fu SIong Ng, Andre R. Simon, Cesare M. Terracciano, Nicholas S. Peters. Scientific Reports (in press)

Myocardial MiR-30 downregulation triggered by doxorubicin drives alterations in β-adrenergic signaling and enhances apoptosis.

Roca-Alonso, L., Castellano, L., Mills, A., Dabrowska, A.F., Sikkel, M.B., Pellegrino, L., Jacob, J., Frampton, A.E., Krell, J., Coombes, R.C. and Harding, S.E., 2015. Cell death & disease6(5), p.e1754.

Major adverse events and atrial tachycardia in Ebstein's anomaly predicted by cardiovascular magnetic resonance.

Rydman R, Shiina Y, Diller GP, Niwa K, Li W, Uemura H, Uebing A, Barbero U, Bouzas B, Ernst S, Wong T, Pennell DJ, Gatzoulis MA, Babu-Narayan SV. Heart. 2018 Jan;104(1):37-44. doi: 10.1136/heartjnl-2017-311274. Epub 2017 Jul 6. PubMed PMID: 28684436; PubMed Central PMCID: PMC5749347.

Titin-truncating variants affect heart function in disease cohorts and the general population.

Schafer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJ, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik JP, O'Regan D, Ware JS, Hubner N, Cook SA. Nat Genet 2017;49(1):46-53.

Upstairs, Downstairs: Atrial and Ventricular Cardiac Myocytes from Human Pluripotent Stem Cells.

Schneider MD. Cell Stem Cell. 2017 Aug 3;21(2):151-152. doi: 10.1016/j.stem.2017.07.006.

T-tubule remodelling disturbs localized β2-adrenergic signalling in rat ventricular myocytes during the progression of heart failure.

Schobesberger, S., Wright, P., Tokar, S., Bhargava, A., Mansfield, C., Glukhov, A.V., Poulet, C., Buzuk, A., Monszpart, A., Sikkel, M. and Harding, S.E., 2017. Cardiovascular research113(7), pp.770-782.

An in-vivo comparison of stimulated-echo and motion compensated spin-echo sequences for 3 T diffusion tensor cardiovascular magnetic  resonance at multiple cardiac phases.

Scott AD, Nielles-Vallespin S, Ferreira PF, Khalique Z, Gatehouse PD, Kilner P, Pennell DJ, Firmin DN. J Cardiovasc Magn Reson. 2018 Jan 3;20(1):1. doi: 10.1186/s12968-017-0425-8. PubMed PMID: 29298692; PubMed Central  PMCID: PMC5753538.

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.

Seneviratne, A.N., Edsfeldt, A.O., Cole, J.E., Kassiteridi, C., Swart, M., Park, I., Green, P., Khoyratty, T.E., Saliba, D.G., Goddard, M.E. and Sansom, S.N., 2017. Circulation, pp.CIRCULATIONAHA-117.

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin.

Sheehan, A., Messer, A.E., Papadaki, M., Choudhry, A., Kren, V., Biedermann, D., Blagg, B., Khandelwal, A. and Marston, S.B., 2018. Frontiers in Physiology9, p.243.

Multimodal Hydrogel-Based Platform To Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM. ACS Cent Sci. 2017 Apr 26;3(4):338-348. doi: 10.1021/acscentsci.7b00039. Epub 2017 Mar 30.

Multimodal Hydrogel-Based Platform to Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MDStevens MM (2017). ACS Central Science. March 30 2017.

Lipoprotein(a) in patients with aortic stenosis: Insights from cardiovascular magnetic resonance.

Vassiliou VS, Flynn PD, Raphael CE, Newsome S, Khan T, Ali A, Halliday B, Studer Bruengger A, Malley T, Sharma P, Selvendran S, Aggarwal N, Sri A, Berry H, Donovan J, Lam W, Auger D, Cook SA, Pennell DJ, Prasad SK. PLoS One. 2017 Jul 13;12(7):e0181077. doi: 10.1371/journal.pone.0181077. eCollection 2017. PubMed PMID: 28704465; PubMed Central PMCID: PMC5509300.

Midwall Fibrosis and 5-Year Outcome in Moderate and Severe Aortic Stenosis.

Vassiliou VS, Perperoglou A, Raphael CE, Joshi S, Malley T, Everett R, Halliday B, Pennell DJ, Dweck MR, Prasad SK. J Am Coll Cardiol. 2017 Apr 4;69(13):1755-1756. doi: 10.1016/j.jacc.2017.01.034. PubMed PMID: 28359524. 

Identification of myocardial diffuse fibrosis by 11 heartbeat MOLLI T (1) mapping: averaging to improve precision and correlation with collagen volume fraction.

Vassiliou VS, Wassilew K, Cameron D, Heng EL, Nyktari E, Asimakopoulos G, de  Souza A, Giri S, Pierce I, Jabbour A, Firmin D, Frenneaux M, Gatehouse P, Pennell DJ, Prasad SK. MAGMA. 2018 Feb;31(1):101-113. doi: 10.1007/s10334-017-0630-3. Epub 2017 Jun 12. PubMed PMID: 28608326; PubMed Central PMCID: PMC5813064.

Evaluation of cardiac and hepatic iron overload in thalassemia major patients with T2* magnetic resonance imaging.

Wahidiyat PA, Liauw F, Sekarsari D, Putriasih SA, Berdoukas V, Pennell DJ. Hematology. 2017 Sep;22(8):501-507. doi: 10.1080/10245332.2017.1292614. Epub 2017 Feb 20. PubMed PMID: 28218005.


Past papers from previous years

Past papers

2016 Papers

A low balance between microparticles expressing tissue factor pathway inhibitor and tissue factor is associated with thrombosis in Behcet's Syndrome.

Khan E, Ambrose NL, Ahnstrom J, Kiprianos AP, Stanford MR, Eleftheriou D, Brogan PA, Mason JC, Johns M, Laffan MA, Haskard DO. Sci Rep. 2016 Dec 7;6:38104. doi: 10.1038/srep38104. PubMed PMID: 27924945

A Prospective Study of Ripple Mapping in Atrial Tachycardias: A Novel Approach to Interpreting Activation in Low-Voltage Areas.

Luther V, Linton NW, Koa-Wing M, Lim PB, Jamil-Copley S, Qureshi N, Ng FS, Hayat S, Whinnett Z, Davies DW, Peters NS, Kanagaratnam P.
Circ Arrhythm Electrophysiol. 2016 Jan;9(1):e003582. doi: 10.1161/CIRCEP.115.003582. PubMed PMID: 26757985.    

A Prospective Study of Ripple Mapping the Post-Infarct Ventricular Scar to Guide Substrate Ablation for Ventricular Tachycardia.

Luther V, Linton NW, Jamil-Copley S, Koa-Wing M, Lim PB, Qureshi N, Ng FS, Hayat S, Whinnett Z, Davies DW, Peters NS, Kanagaratnam P. Circ Arrhythm Electrophysiol. 2016 Jun;9(6). pii: e004072. doi: 10.1161/CIRCEP.116.004072. PMID: 27307519

An array of individually addressable micro-needles for mapping pH distributions.

Zuliani C, Ng FS, Alenda A, Eftekhar A, Peters NS, Toumazou C. Analyst. 2016 Aug 7;141(15):4659-66. doi: 10.1039/c6an00639f. PMID: 27243147

Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function.

Jones S, Lumens J, Sohaib SM, Finegold JA, Kanagaratnam P, Tanner M, Duncan E, Moore P, Leyva F, Frenneaux M, Mason M, Hughes AD, Francis DP, Whinnett ZI, BRAVO Investigators, Peters NS et al Europace. 2016 Jul 13. pii: euw136. PubMed PMID: 27411361

Ectopy-Triggering Ganglionated Plexus Sites May Be An Alternative Target For Atrial Fibrillation Ablation.

Sikkel MB,B Sandler, PB Lim, L Malcolme-Lawes, I Mann, V Luther, S Sohaib, FS Ng, I Wright, N Qureshi, K Leong, M Koa-Wing, Z Whinnett, DW Davies, NS Peters, N Linton, P Kanagaratnam. Heart Rhythm 13(5): S1-S688.

Enhancement of Gap Junction Function During Acute Myocardial Infarction Modifies Healing and Reduces Late Ventricular Arrhythmia Susceptibility.

Ng FS, Kalindjian JM, Cooper SA, Chowdhury RA, Patel PM, Dupont E, Lyon AR, Peters NS. JACC Clin Electrophysiol 2(5):574-582. PMID: 27807593

Formation of Functional Conduction Block during the Onset of Reentrant Ventricular Tachycardia.

Ciaccio EJ, Coromilas J, Wit AL, Peters NS, Garan H. Circ Arrhythm Electrophysiol. 2016 Dec;9(12). pii: e004462. PubMed PMID: 27879278

Formation of re-entrant circuits in the mid-myocardial infarct border zone.

Ciaccio EJ, Coromilas J, Wit AL, Peters NS, Garan H. Comput Biol Med. 2016 Apr 1;71:205-13. doi: 10.1016/j.compbiomed.2016.02.009. Epub 2016 Feb 22. PubMed PMID: 26945600

Heartbreak hotel: a convergence in cardiac regeneration.

Schneider MD. Development. 2016 May 1;143(9):1435-41. doi: 10.1242/dev.133652. PMID: 27143752 

High Serum Immunoglobulin G and M Levels Predict Freedom from Adverse Cardiovascular Events in Hypertension: A Nested Case-Control Substudy of the Anglo-Scandinavian Cardiac Outcomes Trial.

Khamis RY, Hughes AD, Caga-Anan M, Chang CL, Boyle JJ, Kojima C, Welsh P, Sattar N, Johns M, Sever P, Mayet J, Haskard DO. EBioMedicine. 2016 Jul;9:372-80. doi: 10.1016/j.ebiom.2016.06.012. Epub 2016 Jun 20. PubMed PMID: 27333022

 
Intimal and medial contributions to the hydraulic resistance of the arterial wall at different pressures: a combined computational and experimental study.
 

Chooi KY, Comerford A, Sherwin SJ, Weinberg PD. J R Soc Interface. 2016 Jun;13(119). pii: 20160234. doi: 10.1098/rsif.2016.0234. PMID: 27307514

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation.

Thornton CC, Al-Rashed F, Calay D, Birdsey GM, Bauer A, Mylroie H, Morley BJ, Randi AM, Haskard DO, Boyle JJ, Mason JC. Ann Rheum Dis. 2016 Feb;75(2):439-48. doi: 10.1136/annrheumdis-2014-206305. Epub 2015 Jan 9. PubMed PMID: 25575725

Mini Bypass and Proinflammatory Leukocyte Activation: A Randomized Controlled Trial.

Nguyen BA, Fiorentino F, Reeves BC, Baig K, Athanasiou T, Anderson JR, Haskard DO, Angelini GD, Evans PC. Ann Thorac Surg. 2016 Apr;101(4):1454-63. doi: 10.1016/j.athoracsur.2015.09.029. Epub 2015 Nov 18. PubMed PMID: 26602006

Multimodal Hydrogel-Based Platform to Deliver and Monitor Cardiac Progenitor/Stem Cell Engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM. Development. 2016 May 1;143(9):1435-41. doi: 10.1242/dev.133652. PMID: 27143752  

Myocardial architecture and patient variability in clinical patterns of atrial fibrillation.

Manani KA, Christensen K, Peters NS (2016). Phys Rev E. 2016 Oct;94(4-1):042401. PMID: 27841583

Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis.

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Chang SH, Malik TH, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DO. Sci Rep. 2016 Feb 25;6:21785. doi: 10.1038/srep21785. PubMed PMID: 26911995

New paradigms in cardiovascular calcification.

Agarwal S and Bertazzo S (2016). Comptes Rendus Chimie, 19(11), pp.1605-1609.  

Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium.

Zaman JA, Harling L, Ashrafian H, Darzi A, Gooderham N, Athanasiou T, Peters NS.Int J Cardiol. 2016 Oct 1;220:580-8. doi:10.1016/j.ijcard.2016.06.249. PMID: 27390994.

Role of endothelial permeability hotspots and endothelial mitosis in determining age-related patterns of macromolecule uptake by the rabbit aortic wall near branch points.

Chooi KY, Comerford A, Cremers SJ, Weinberg PD. Atherosclerosis. 2016 Jul;250:77-83. doi: 10.1016/j.atherosclerosis.2016.05.017 PMID: 27182961 

Systemic autoimmunity induced by Toll-like receptor 7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy; a new model of autoimmune heart disease.

Hasham MG, Baxan N, Stuckey DJ, Dent O, Branca J, Perkins BRA, Duffy T, Hameed TS, Stella SE, Bellahcene M, Schneider MD, Harding SE, Rosenthal N, Sattler S. Development. 2016 May 1;143(9):1435-41. doi: 10.1242/dev.133652. PMID: 27143752

Zebrafish Model for Functional Screening of Flow-Responsive Genes.

Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton JP, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJ, Evans PC. Ann Thorac Surg. 2016 Apr;101(4):1454-63. doi: 10.1016/j.athoracsur.2015.09.029. Epub 2015 Nov 18. PubMed PMID: 26602006

2017 Papers

Air pollution and cardiovascular mortality with over 25years follow-up: A combined analysis of two British cohorts.

Dehbi HM, Blangiardo M, Gulliver J, Fecht D, de Hoogh K, Al-Kanaani Z, Tillin T, Hardy R, Chaturvedi N, Hansell AL. Environ Int. 2017 Feb;99:275-281. doi: 10.1016/j.envint.2016.12.004. PMID: 27939045

Characterization and consistency of interactions of triggers and substrate at the onset of paroxysmal atrial fibrillation.

Jones DG, Markides V, Chow AW, Schilling RJ, Kanagaratnam P, Wong T, Davies DW and Peters, NS. Europace. 2017 Jan 25. doi: 10.1093/europace/euw229. PubMed PMID: 28339601

Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane.

Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c. PMID: 28439590

Development of an automaton model of rotational activity driving atrial fibrillation.

Ciaccio EJ, Biviano AB, Wan EY, Peters NS, Garan H. Comput Biol Med. 2017 Apr 1;83:166-181. doi: 10.1016/j.compbiomed.2017.02.008. Epub 2017 Mar 2. PubMed PMID: 28282592

Multi-modal hydrogel platform to enhance and monitor cardiac progenitor/stem cell engraftment.

Speidel AT, Stuckey DJ, Chow LW, Jackson L, Noseda M, Abreu Paiva M, Schneider MD, Stevens MM. ACS Cent Sci. 2017 Apr 26;3(4):338-348. doi: 10.1021/acscentsci.7b00039. PMID:28470052

Noradrenaline has opposing effects on the hydraulic conductance of arterial intima and media.

Chooi KY, Comerford A, Sherwin SJ, Weinberg PD. J Biomech. 2017 Mar 21;54:4-10. doi: 10.1016/j.jbiomech.2017.01.027. PMID: 28256247

Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation.

Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Thomas NM, Gray R, Fry CH, Desplantez T, Peters NS, Severs NJ, Macleod KT, Tweedy JH, Ng FS, Peters NS. Ann Biomed Eng. 2017 Apr;45(4):910-923. doi: 10.1007/s10439-016-1766-4. Epub 2016 Dec 5. PubMed PMID: 27921187

Titin-truncating variants affect heart function in disease cohorts and the general population.

Schafer A, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, Rackham OJ, van Heesch S, Pua CJ, Kui M, Walsh R, Tayal U, Prasad SK, Dawes TJW, Ko NS, Sim D, Chan LL, Chin CW, Mazzarotto F, Barton PJ, Kreuchwig F, de Kleijn DP, Totman T, Biffi C, Tee N, Rueckert D, Schneider V, Faber A, Regitz-Zagrosek V, Seidman JG, Seidman CE, Linke WA, Kovalik KP, O'Regan D, Ware JS, Hubner N, Cook SA. Nat Genet. 2017 Jan;49(1):46-53. doi: 10.1038/ng.3719. Epub 2016 Nov 21. PubMed PMID: 26911995

Tipifarnib prevents development of hypoxia-induced pulmonary hypertension.

Duluc L, Ahmetaj-Shala B, Mitchell J, Abdul Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR, Wojciak-Stothard B (2017). Cardiovasc Res. 2017 Mar 1;113(3):276-287. doi: 10.1093/cvr/cvw258. PMID: 28395021

Understanding the fluid mechanics behind transverse wall shear stress.

Mohamied Y, Sherwin SJ and Weinberg PD. J Biomech. 2017 Jan 4;50:102-109. doi: 10.1016/j.jbiomech.2016.11.035. PMID: 27863740

2015 papers

A Targeting Microbubble for Ultrasound Molecular Imaging.
Yeh JS, Sennoga CA, McConnell E, Eckersley R, Tang MX, Nourshargh S, Seddon JM, Haskard DO, Nihoyannopoulos P.
PLoS One. 2015 Jul 10;10(7):e0129681. doi:10.1371/journal.pone.0129681.
eCollection 2015. PubMed PMID: 26161541; PubMed Central PMCID: PMC4498921.

Low shear stress induces M1 macrophage polarisation in murine thin-cap atherosclerotic plaques.
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R, Monaco C.
J Mol Cell Cardiol. 2015 Dec;89(Pt B):168-72. doi: 10.1016/j.yjmcc.2015.10.034. Epub 2015 Oct 30. PubMed PMID: 26523517.

A technique for visualising three-dimensional left atrial cardiac activation data in two dimensions with minimal distance distortion.
Roney CH, Tzortzis KN, Cantwell CD, Qureshi NA, Ali RL, Phang Boon Lim, Siggers JH, Fu Siong Ng, Peters NS.
Conf Proc IEEE Eng Med Biol Soc. 2015 Aug;2015:7296-9. doi:10.1109/EMBC.2015.7320076. PubMed PMID: 26737976.

Autologous dermal fibroblast injections slow atrioventricular conduction and ventricular rate in atrial fibrillation in swine.
Tondato F, Zeng H, Goodchild T, Ng FS, Chronos N, Peters NS.
Circ Arrhythm Electrophysiol. 2015 Apr;8(2):439-46.
doi: 10.1161/CIRCEP.114.001536. Epub 2015 Jan 31. PubMed PMID: 25638212.

PDGFRα demarcates the cardiogenic clonogenic Sca1+ stem/progenitor cell in adult murine myocardium.
Noseda M, Harada M, McSweeney S, Leja T, Belian E, Stuckey DJ, Abreu Paiva MS, Habib J, Macaulay I, de Smith AJ, al-Beidh F, Sampson R, Lumbers RT, Rao P, Harding SE, Blakemore AI, Jacobsen SE, Barahona M, Schneider MD.
Nat Commun. 2015 May 18;6:6930. doi: 10.1038/ncomms7930. PubMed PMID: 25980517.

ZBTB17 (MIZ1) Is Important for the Cardiac Stress Response and a Novel Candidate Gene for Cardiomyopathy and Heart Failure.
Buyandelger B, Mansfield C, Kostin S, Choi O, Roberts AM, Ware JS, Mazzarotto F, Pesce F, Buchan R, Isaacson RL, Vouffo J, Gunkel S, Knöll G, McSweeney SJ, Wei H, Perrot A, Pfeiffer C, Toliat MR, Ilieva K, Krysztofinska E, López-Olañeta MM, Gómez-Salinero JM, Schmidt A, Ng KE, Teucher N, Chen J, Teichmann M, Eilers M, Haverkamp W, Regitz-Zagrosek V, Hasenfuss G, Braun T, Pennell DJ, Gould I, Barton PJ, Lara-Pezzi E, Schäfer S, Hübner N, Felkin LE, O'Regan DP, Brand T, Milting H, Nürnberg P, Schneider MD, Prasad S, Petretto E, Knöll R.
Circ Cardiovasc Genet. 2015 Oct;8(5):643-52. doi: 10.1161/CIRCGENETICS.113.000690. Epub 2015 Jul 14. PubMed PMID: 26175529.

Cardiac-Restricted IGF-1Ea Overexpression Reduces the Early Accumulation of Inflammatory Myeloid Cells and Mediates Expression of Extracellular Matrix Remodelling Genes after Myocardial Infarction.
Gallego-Colon E, Sampson RD, Sattler S, Schneider MD, Rosenthal N, Tonkin J.
Mediators Inflamm. 2015;2015:484357. doi: 10.1155/2015/484357. Epub 2015 Sep 30. PubMed PMID: 26491228.

Monocyte/Macrophage-derived IGF-1 Orchestrates Murine Skeletal Muscle Regeneration and Modulates Autocrine Polarization.
Tonkin J, Temmerman L, Sampson RD, Gallego-Colon E, Barberi L, Bilbao D, Schneider MD, Musarò A, Rosenthal N. 
Mol Ther. 2015 Jul;23(7):1189-200. doi: 10.1038/mt.2015.66. Epub 2015 Apr 21. PubMed PMID: 25896247.

Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5.
Belian E, Noseda M, Abreu Paiva MS, Leja T, Sampson R, Schneider MD.
PLoS One. 2015 Jun 5;10(6):e0125384. doi: 10.1371/journal.pone.0125384.
eCollection 2015. PubMed PMID: 26047103.

Enhanced efficiency of genetic programming toward cardiomyocyte creation through topographical cues.
Morez C, Noseda M, Paiva MA, Belian E, Schneider MD, Stevens MM.
Biomaterials. 2015 Nov;70:94-104. doi:10.1016/j.biomaterials.2015.07.063. Epub 2015 Aug 8. PubMed PMID: 26302234.

Comparison of Statistical Methods for Assessing Spatial Correlations Between Maps of Different Arterial Properties.
Rowland EM, Mohamied Y, Yean Chooi K, Bailey EL, Weinberg PD.
J Biomech Eng. 2015 Oct;137(10):101003. doi:10.1115/1.4031119. PubMed PMID: 26201866.

A combined numerical and experimental framework for determining permeability properties of the arterial media.
Comerford A, Chooi KY, Nowak M, Weinberg PD, Sherwin SJ.
Biomech Model Mechanobiol. 2015 Apr;14(2):297-313. doi:10.1007/s10237-014-0604-6. Epub 2014 Jul 17. PubMed PMID: 25027803.

2014 papers

PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression.
Iqbal MB, Johns M, Cao J, Liu Y, Yu SC, Hyde GD, Laffan MA, Marchese FP, Cho SH, Clark AR, Gavins FN, Woollard KJ, Blackshear PJ, Mackman N, Dean JL, Boothby  M, Haskard DO.
Blood. 2014 Dec 4;124(24):3646-55. doi: 10.1182/blood-2014-07-588046.
Epub 2014 Oct 7. PubMed PMID: 25293769.

Disturbed flow promotes endothelial senescence via a p53-dependent pathway.
Warboys CM, de Luca A, Amini N, Luong L, Duckles H, Hsiao S, White A, Biswas S, Khamis R, Chong CK, Cheung WM, Sherwin SJ, Bennett MR, Gil J, Mason JC, Haskard DO, Evans PC.
Arterioscler Thromb Vasc Biol. 2014 May;34(5):985-95. doi:
10.1161/ATVBAHA.114.303415. Epub 2014 Mar 20. PubMed PMID: 24651677.

ICAM-2 regulates vascular permeability and N-cadherin localisation through ezrin-radixin-moesin (ERM) proteins and Rac-1 signalling.
Amsellem V, Dryden NH, Martinelli R, Gavins F, Almagro LO, Birdsey GM, Haskard DO, Mason JC, Turowski P, Randi AM.
Cell Commun Signal. 2014 Mar 4;12:12. doi: 10.1186/1478-811X-12-12. PubMed PMID: 24593809.

Requirement of JNK1 for endothelial cell injury in atherogenesis.
Amini N, Boyle JJ, Moers B, Warboys CM, Malik TH, Zakkar M, Francis SE, Mason JC, Haskard DO, Evans PC.
Atherosclerosis. 2014 Aug;235(2):613-8. doi:10.1016/j.atherosclerosis.2014.05.950. Epub 2014 Jun 12. PubMed PMID: 24956536.

Sulforaphane pretreatment prevents systemic inflammation and renal injury in response to cardiopulmonary bypass.
Nguyen B, Luong L, Naase H, Vives M, Jakaj G, Finch J, Boyle J, Mulholland JW, Kwak JH, Pyo S, de Luca A, Athanasiou T, Angelini G, Anderson J, Haskard DO, Evans PC.
J Thorac Cardiovasc Surg. 2014 Aug;148(2):690-697.e3. doi: 10.1016/j.jtcvs.2013.12.048. Epub 2014 Jan 15. PubMed PMID: 24521949.

Synergistic therapeutic vascular cytoprotection against complement-mediated injury induced via a PKCα-, AMPK-, and CREB-dependent pathway.
Hamdulay SS, Wang B, Calay D, Kiprianos AP, Cole J, Dumont O, Dryden N, Randi AM, Thornton CC, Al-Rashed F, Hoong C, Shamsi A, Liu Z, Holla VR, Boyle JJ, Haskard DO, Mason JC.
J Immunol. 2014 May 1;192(9):4316-27. doi: 10.4049/jimmunol.1301702. Epub 2014 Mar 26. PubMed PMID: 24670799.

Elevated uptake of plasma macromolecules by regions of arterial wall predisposed to plaque instability in a mouse model. 
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ, Weinberg PD. 
PLoS One. 2014 Dec 22;9(12):e115728. doi: 10.1371/journal.pone.0115728. eCollection 2014. PubMed PMID: 25531765.

Simple model for identifying critical regions in atrial fibrillation.
Christensen K, Manani KA, Peters NS.
Phys Rev Lett. 2015 Jan 16;114(2):028104. Epub 2015 Jan 16. PubMed PMID: 25635565.

Characterisation of connexion expression and electrophysiological properties in stable clones of the HL-1 myocyte cell line.
Dias P, Desplantez T, El-Harasis MA, Chowdhury RA, Ullrich ND, Cabestrero de Diego A, Peters NS, Severs NJ, MacLeod KT, Dupont E.
PLoS One. 2014 Feb 28;9(2):e90266. doi: 10.1371/journal.pone.0090266. eCollection 2014. PubMed PMID: 24587307.

Insulin-like growth factor-1 induces regulatory T cell-mediated suppression of allergic contact dermatitis in mice.
Johannesson B, Sattler S, Semenova E, Pastore S, Kennedy-Lydon TM, Sampson RD, Schneider MD, Rosenthal N, Bilbao D.
Dis Model Mech. 2014 Aug;7(8):977-85. doi: 10.1242/dmm.015362. PubMed PMID: 25056699.

HGK/MAP4K4 deficiency induces TRAF2 stabilisation and Th17 differentiation leading to insulin resistance.
Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan TH.
Nat Commun. 2014 Aug 6;5:4602. doi: 10.1038/ncomms5602. PubMed PMID: 25098764.

Raman spectroscopic evidence of tissue restructuring in heat-induced tissue fusion.
Su L, Cloyd KL, Arya S, Hedegaard MA, Steele JA, Elson DS, Stevens MM, Hanna GB.
J Biophotonics. 2014 Sep;7(9):713-23. doi: 10.1002/jbio.201300099. Epub 2013 Nov 15. PubMed PMID: 24243853.

Flow-dependent concentration polarisation and the endothelial glycocalyx layer: multi-scale aspects of arterial mass transport and their implications for atherosclerosis.
Vincent PE, Weinberg PD.
Biomech Model Mechanobiol. 2014 Apr;13(2):313-26. doi: 10.1007/s10237-013-0512-1. Epub 2013 Jul 9. Review. PubMed PMID: 23836008.

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signalling.
Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk AI, Sikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J.
J Mol Cell Cardiol. 2014 Feb;67:38-48. doi: 10.1016/j.yjmcc.2013.12.003. PubMed PMID: 24345421

Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress.
Pedrigi RM, de Silva R, Bovens SM, Mehta V, Petretto E, Krams R.
Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2224-31. doi: 10.1161/ATVBAHA.114.303426. PubMed PMID: 25060797

High-order spectral/hp element discretization for reaction-diffusion problems on surfaces: application to cardiac electrophysiology.
Cantwell C, Yakovlev S, Kirby R, Peters NS, Sherwin S.
J Comput Phys. 2014 Jan 15;257(PA):813-829. PubMed PMID: 24748685

T1 mapping detects pharmacological retardation of diffuse cardiac fibrosis in mouse pressure-overload hypertrophy.
Stuckey DJ, McSweeney SJ, Thin MZ, Habib J, Price AN, Fiedler LR, Gsell W, Prasad SK, Schneider MD.
Circ Cardiovasc Imaging. 2014 Mar;7(2):240-9. doi: 10.1161/CIRCIMAGING.113.000993. PubMed PMID: 24425501

Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
Liu Y, Kaneda R, Leja TW, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz RJ, Barahona M, Schneider MD.
Stem Cells. 2014 Jun;32(6):1515-26. doi: 10.1002/stem.1695. PubMed PMID: 24585688

Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer.
Krell J, Frampton AE, Mirnezami, R, Harding V, De Giorgio A, Roca-Alonso L, Cohen P, Ottaviani S, Colombo T, Jacob J, Pellegrino L, Buchanan G, Stebbing J, Castellano L.
PLoS One. 2014 Jun 13;9(6):e98561. doi: 10.1371/journal.pone.0098561. eCollection 2014. PubMed PMID: 24926850

Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial Hypertension.
Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JS, Wharton J, Zhao L, Wilkins MR.
Circulation. 2014 Apr 29;129(17):1770-80. doi: 10.1161/CIRCULATIONAHA.113.006797. PubMed PMID: 24503951

Genetic analysis of the cardiac methylome at single nucleotide resolution in a model of human cardiovascular disease.
Johnson MD, Mueller M, Adamowicz-Brice M, Collins MJ, Gellert P, Maratou K, Srivastava PK, Rotival M, Butt S, Game L, Atanur SS, Silver N, Norsworthy PJ, Langley SR, Petretto E, Pravenec M, Aitman TJ.
PLoS Genet. 2014 Dec 4;10(12):e1004813. doi: 10.1371/journal.pgen.1004813. eCollection. PubMed PMID: 25474312

2013 papers

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.
Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC.
Circ Res. 2013 Jun 7;112(12):1583-91. doi:
10.1161/CIRCRESAHA.111.300119. Epub 2013 Apr 5. PubMed PMID: 23564640.

Characterization of the left atrial neural network and its impact on autonomic modification procedures.
Malcolme-Lawes LC, Lim PB, Wright I, Kojodjojo P, Koa-Wing M, Jamil-Copley S, Dehbi HM, Francis DP, Davies DW, Peters NS, Kanagaratnam P.
Circ Arrhythm Electrophysiol. 2013 Jun;6(3):632-40. doi:
10.1161/CIRCEP.113.000193. Epub 2013 Apr 11. PubMed PMID: 23580743.

A probabilistic patch-based label fusion model for multi-atlas segmentation with registration refinement: application to cardiac MR images.
Bai W, Shi W, O'Regan DP, Tong T, Wang H, Jamil-Copley S, Peters NS, Rueckert D.
IEEE Trans Med Imaging. 2013 Jul;32(7):1302-15. doi: 10.1109/TMI.2013.2256922. Epub 2013 Apr 5. PubMed PMID: 23568495.

Cardiac fibrosis in mice expressing an inducible myocardial-specific Cre driver.
Lexow J, Poggioli T, Sarathchandra P, Santini MP, Rosenthal N.
Dis Model Mech. 2013 Nov;6(6):1470-6. doi: 10.1242/dmm.010470. Epub 2013 Aug 7. PubMed PMID: 23929940.

Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification.
Bertazzo S, Gentleman E, Cloyd KL, Chester AH, Yacoub MH, Stevens MM.
Nat Mater. 2013 Jun;12(6):576-83. doi:10.1038/nmat3627. Epub 2013 Apr 21. PubMed PMID: 23603848.

Computation in the rabbit aorta of a new metric - the transverse wall shear stress - to quantify the multidirectional character of disturbed blood flow.
Peiffer V, Sherwin SJ, Weinberg PD.
J Biomech. 2013 Oct 18;46(15):2651-8. doi:10.1016/j.jbiomech.2013.08.003. Epub 2013 Aug 30. PubMed PMID: 24044966.

A novel method for quantifying spatial correlations between patterns of atherosclerosis and hemodynamic factors.
Peiffer V, Bharath AA, Sherwin SJ, Weinberg PD.
J Biomech Eng. 2013 Feb;135(2):021023. doi: 10.1115/1.4023381. PubMed PMID: 23445068.

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat.
Atanur SS, Diaz AG, Maratou K, Sarkis A, Rotival M, Game L, Tschannen MR, Kaisaki PJ, Otto GW, Ma MC, Keane TM, Hummel O, Saar K, Chen W, Guryev V, Gopalakrishnan K, Garrett MR, Joe B, Citterio L, Bianchi G, McBride M, Dominiczak A, Adams DJ, Serikawa T, Flicek P, Cuppen E, Hubner N, Petretto E, Gauguier D, Kwitek A, Jacob H, Aitman TJ.
Cell. 2013 Aug 1;154(3):691-703. doi: 10.1016/j.cell.2013.06.040. PubMed PMID: 23890820

Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, Jagodic M, Tuncel J, Norin U, Beattie E, Huynh N, Miller WH, Koller DL, Alam I, Falak S, Osborne-Pellegrin M, Martinez-Membrives E, Canete T, Blazquez G, Vicens-Costa E, Mont-Cardona C, Diaz-Moran S, Tobena A, Hummel O, Zelenika D, Saar K, Patone G, Bauerfeind A, Bihoreau MT, Heinig M, Lee YA, Rintisch C, Schulz H, Wheeler DA, Worley KC, Muzny DM, Gibbs RA, Lathrop M, Lansu N, Toonen P, Ruzius FP, de Bruijn E, Hauser H, Adams DJ, Keane T, Atanur SS, Aitman TJ, Flicek P, Malinauskas T, Jones EY, Ekman D, Lopez-Aumatell R, Dominiczak AF, Johannesson M, Holmdahl R, Olsson T, Gauguier D, Hubner N, Fernandez-Teruel A, Cuppen E, Mott R, Flint J.
Nat Genet. 2013 Jul;45(7):767-75. doi: 10.1038/ng.2644. PubMed PMID: 23708188

Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy
.
Gulati A, Ismail TF, Jabbour A, Ismail NA, Morarji K, Ali A, Raza S, Khwaja J, Brown TDH, Liodakis E, Baksi AJ, Shakur R, Guha K, Roughton M, Wage R, Cook SA, Alpendurada F, Assomull RG, Mohiaddin RH, Cowie MR, Pennell DJ, Prasad SK.
Eur J Heart Fail. 2013 Jun;15(6):660-70. doi: 10.1093/eurjhf/hft019. PubMed PMID: 23475781

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow.
Caro CG, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P, Coppola G.
J R Soc Interface. 2013 Oct 16;10(89):20130578. doi: 10.1098/rsif.2013.0578. PubMed PMID: 24132200

Systems biology of the functional and dysfunctional endothelium.
Frueh J, Maimari N, Homma T, Bovens S, Pedrigi RM, Towhidi L, Krams R.
Cardiovasc Res. 2013 Jul 15;99(2):334-41. doi: 10.1093/cvr/cvt108. PubMed PMID: 23650287

Relationship between gap-junctional conductance and conduction velocity in mammalian myocardium.
Dhillon PS, Gray R, Kojodjojo P, Jabr R, Chowdhury R, Fry CH, Peters NS.
Circ Arrhythm Electrophysiol. 2013 Dec;6(6):1208-14. doi: 10.1161/CIRCEP.113.000848. PubMed PMID: 24134868

Automated analysis of atrial delayed enhancement cardiac MRI correlates with voltage, AF recurrence post-ablation, and high stroke risk.
Malcolme-Lawes L, Juli C, Karim R, Bai W, Quest R, Lim PB, Jamil-Copley S, Kojodjojo P, Ariff B, Davies DW, Rueckert D, Hunter R, Boubertakh R, Petersen S, Schilling R, Kanagaratnam P, and Peters NS.
Heart Rhythm. 2013 Aug;10(8):1184-91. doi: 10.1016/j.hrthm.2013.04.030. PubMed PMID: 23685170

Robotic-assistance and general anaesthesia improve catheter stability and increase signal attenuation during atrial fibrillation ablation.
Malcolme-Lawes L, Lim PB, Koa-Wing M, Whinnett ZI, Jamil-Copley S, Hayat S, Francis DP, Kojodjojo P, Davies DW, Peters NS, Kanagaratnam P.
Europace. 2013 Jan;15(1):41-7. doi: 10.1093/europace/eus244. PubMed PMID: 22915788

Ablation of SGK1 impairs endothelial cell migration and tube formation leading to decreased neo-angiogenesis following myocardial infarction.
Zarrinpashneh, E., Poggioli T, Sarathchandra P, Monassier L, Terracciano C, Lang F, Damilano F, Zhou JQ, Rosenzweig A, Rosenthal N, Santini MP.
PLoS One. 2013 Nov 12;8(11):e80268. doi: 10.1371/journal.pone.0080268. PubMed PMID: 24265802

A critical role for telethonin in regulating t-tubule structure and function in the mammalian heart.
Ibrahim M, Siedlecka U, Buyandelger B, Harada M, Rao C, Moshkov A, Bhargava A, Schneider M, Yacoub M, Gorelik J, Knöll R, Terracciano C.
Hum Mol Genet. 2013 Jan 15;22(2):372-83. doi: 10.1093/hmg/dds434. PubMed PMID: 23100327

Evaluation of C-reactive protein before and on-treatment as a predictor of benefit atorvastatin.
Sever PS, Poulter NR, Chang CL, Thom SAM, Hughes AH, Welsh P, Sattar N, on behalf of the ASCOT Investigators.
J Am Coll Cardiol. 2013 Aug 20;62(8):717-29. doi: 10.1016/j.jacc.2013.02.098. PubMed PMID: 23948514

Does low and oscillatory wall shear stress correlate spatially with early atherosclerosis? A systematic review.
Peiffer V, Sherwin SJ, Weinberg PD.
Cardiovasc Res. 2013 Jul 15;99(2):242-50. doi: 10.1093/cvr/cvt044. PubMed PMID: 23459102

Reduced microR-150 is Associated with Poor Survival in Pulmonary Arterial Hypertension
.
Rhodes CJ, Wharton J, Boon RA, Roexe T, Tsang H, Wojciak-Stothard B, Chakrabarti A, Howard LS, Gibbs JSR, Lawrie A, Condliffe R, Elliot CA, Kiely DG, Huson L, Ghofrani HA, Tiede H, Schermuly R, Zeiher AM, Dimmeler S, Wilkins MR.

Am J Respir Crit Care Med. 2013 Feb 1;187(3):294-302. doi: 10.1164/rccm.201205-0839OC. PubMed PMID: 23220912

2012 papers

Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia.
Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO, Botto M.
Arthritis Rheum. 2012 Aug;64(8):2707-18. doi: 10.1002/art.34451. PubMed PMID: 22392450.

The transcription factor Erg regulates expression of histone deacetylase 6 and multiple pathways involved in endothelial cell migration and angiogenesis.
Birdsey GM, Dryden NH, Shah AV, Hannah R, Hall MD, Haskard DO, Parsons M, Mason JC, Zvelebil M, Gottgens B, Ridley AJ, Randi AM. 
Blood. 2012 Jan 19;119(3):894-903. doi: 10.1182/blood-2011-04-350025. Epub 2011 Nov 23. PubMed PMID: 22117042.

The transcription factor Erg controls endothelial cell quiescence by repressing activity of nuclear factor (NF)-κB p65. 
Dryden NH, Sperone A, Martin-Almedina S, Hannah RL, Birdsey GM, Khan ST, Layhadi JA, Mason JC, Haskard DO, Göttgens B, Randi AM.
J Biol Chem. 2012 Apr 6;287(15):12331-42. doi: 10.1074/jbc.M112.346791. Epub 2012 Feb 15. PubMed PMID: 22337883.

Systems and synthetic biology of the vessel wall.
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G, Krams R.
FEBS Lett. 2012 Jul 16;586(15):2164-70. doi: 10.1016/j.febslet.2012.04.031. Epub 2012 May 3. PubMed PMID: 22710159.

Spatiotemporal behaviour of high dominant frequency during paroxysmal and persistent atrial fibrillation in the human left atrium.
Jarman JW, Wong T, Kojodjojo P, Spohr H, Davies JE, Roughton M, Francis DP, Kanagaratnam P, Markides V, Davies DW, Peters NS.
Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):650-8. doi: 10.1161/CIRCEP.111.967992. Epub 2012 Jun 20. PubMed PMID: 22722660.

Characterization of porcine aortic valvular interstitial cell 'calcified' nodules.
Cloyd KL, El-Hamamsy I, Boonrungsiman S, Hedegaard M, Gentleman E, Sarathchandra P, Colazzo F, Gentleman MM, Yacoub MH, Chester AH, Stevens MM.
PLoS One. 2012;7(10):e48154. doi: 10.1371/journal.pone.0048154. Epub 2012 Oct 26. PubMed PMID: 23110195.

Haemodynamics in the mouse aortic arch computed from MRI-derived velocities at the aortic root.
Van Doormaal MA, Kazakidi A, Wylezinska M, Hunt A, Tremoleda JL, Protti A, Bohraus Y, Gsell W, Weinberg PD, Ethier CR.
J R Soc Interface. 2012 Nov 7;9(76):2834-44. Epub 2012 Jul 4. PubMed PMID: 22764131.

High throughput en face mapping of arterial permeability using tile scanning confocal microscopy.
Clarke LA, Mohri Z, Weinberg PD.
Atherosclerosis. 2012 Oct;224(2):417-25. doi: 10.1016/j.atherosclerosis.2012.08.001. Epub 2012 Aug 23. PubMed PMID: 22947421.

Shape and compliance of endothelial cells after shear stress in vitro or from different aortic regions: scanning ion conductance microscopy study.
Potter CM, Schobesberger S, Lundberg MH, Weinberg PD, Mitchell JA, Gorelik J.
PLoS One. 2012;7(2):e31228. doi: 10.1371/journal.pone.0031228. Epub 2012 Feb 16. PubMed PMID: 22359578.

Complete cardiac regeneration in a mouse model of myocardial infarction.
Haubner BJ*, Adamowicz-Brice M*, Khadayate S, Tiefenthaler V, Metzler B, Aitman T, Penninger JM. *Joint first author
Aging (Albany NY). 2012 Dec;4(12):966-77. PubMed PMID: 26659640

Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans.
Langley SR, Bottolo L, Kunes J, Zicha J, Zidek V, Hubner N, Cook SA, Pravenec M, Aitman TJ and Petretto E.
Cardiovasc Res. 2013 Mar 15;97(4):653-65. doi: 10.1093/cvr/cvs329. PubMed PMID: 23118132

Remodelling after acute myocardial infarction: mapping ventricular dilatation using three-dimensional CMR image registration.
O’Regan DP, Shi W, Ariff B, Baksi AJ, Durighel G, Rueckert D, Cook SA.
J Cardiovasc Magn Reson. 2012 Jun 21;14:41. doi: 10.1186/1532-429X-14-41. PubMed PMID: 22720881

Attenuation of wave reflection by wave entrapment creates a “horizon effect” in the human aorta.
Davies JE, Alastruey J, Francis DP, Hadjiloizou N, Whinnett ZI, Manisty CH, Aguado-Sierra J, Willson K, Foale RA, Malik IS, Hughes AD, Parker KH, Mayet J.
Hypertension. 2012 Sep;60(3):778-85. doi: 10.1161/HYPERTENSIONAHA.111.180604. PubMed PMID: 22802223

Improvement in coronary blood flow velocity with acute biventricular pacing is predominantly due to an increase in a diastolic backward-travelling decompression (suction) wave.
Kyriacou A, Whinnett ZI, Sen S, Pabari PA, Wright I, Cornelussen R, Lefroy D, Davies DW, Peters NS, Kanagaratnam P, Mayet J, Hughes AD, Francis DP, Davies JE.
Circulation. 2012 Sep 11;126(11):1334-44. doi: 10.1161/CIRCULATIONAHA.111.075606. PubMed PMID: 22855569

Plasticity of surface structures and β2-adrenergic receptor localisation in failing ventricular cardiomyocytes during recovery from heart failure.
Lyon AR, Nikolaev VO, Miragoli M, Sikkel MB, Paur H, Benard L, Hulot J-S, Kohlbrenner E, Hajjar RJ, Peters NS, Korchev YE, Macleod KT, Harding SE, Gorelik J.
Circ Heart Fail. 2012 May 1;5(3):357-65. doi: 10.1161/CIRCHEARTFAILURE.111.964692. PubMed PMID: 22456061

Cyclo-oxygenase-1 and not cyclo-oxygenase-2 is responsible for physiological production of prostacyclin in the cardiovascular system.
Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CMF, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA.
Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. PubMed PMID: 23045674

Reducing the data Analysis of the role of vascular geometry on blood flow patterns in curved vessels.
Alastruey J, Siggers JH, Peiffer V, Doorly DJ, Sherwin SJ.
Phys. Fluids, 2012. 24:031902. doi: 10.1063/1.3694526

The Anglo-Scandinavian Cardiac Outcomes Trial: Implications and Further Outcomes.
Sever PS.
Hypertension. 2012 Aug;60(2):248-59. doi: 10.1161/HYPERTENSIONAHA.111.187070. PubMed PMID: 22753211

Evaluation of C-reactive protein prior to and on-treatment as a predictor of benefit from atorvastatin: observations from the Anglo-Scandinavian Cardiac Outcomes Trial.
Sever PS, Poulter NR, Chang CL, Hingorani A, Thom SA, Hughes AD, Welsh P, Sattar N, on behalf of the ASCOT Investigators.
Eur Heart J. 2012 Feb;33(4):486-94. doi: 10.1093/eurheartj/ehr262. PubMed PMID: 21798891

Effect of aortic taper on patterns of blood flow and wall shear stress in rabbits: association with age.
Peiffer V, Rowland EM, Cremers SG, Weinberg PD, Sherwin SJ.
Atherosclerosis. 2012 Jul;223(1):114-21. doi: 10.1016/j.atherosclerosis.2012.04.020. PubMed PMID: 22658260

2011 papers

Integrated genomic approaches to identification of candidate genes underlying metabolic and cardiovascular phenotypes in the spontaneously hypertensive rat.
Morrissey C, Grieve IC, Heinig M, Atanur S, Petretto E, Pravenec M, Hubner N, Aitman TJ.
Physiol Genomics. 2011 Nov 7;43(21):1207-18. doi: 10.1152/physiolgenomics.00210.2010. PubMed PMID: 21846806

Protein multi-scale organisation through graph partitioning and robustness analysis: application to the myosin-myosin light chain interaction.
Delmotte A, Tate EW, Yaliraki SN, Barahona M.
Phys Biol. 2011 Oct;8(5):055010. doi: 10.1088/1478-3975/8/5/055010. PubMed PMID: 21832797

Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function.
McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA.
Nature. 2011 Oct 5;478(7367):114-8. doi: 10.1038/nature10490. PubMed PMID: 21979051

Scanning ion conductance microscopy: a convergent high-resolution technology for multi-parametric analysis of living cardiovascular cells.
Miragoli M, Moshkov A, Novak P, Shevchuk A, Nikolaev VO, El-Hamamsy I, Potter CMF, Wright P, Sheikh Abdul Kadir SH, Lyon AR, Mitchell JA, Chester AH, Klenerman D, Lab MJ, Korchev YE, Harding SE, and Gorelik J.
J R Soc Interface. 2011 Jul 6;8(60):913-25. doi: 10.1098/rsif.2010.0597. PubMed PMID: 21325316

Molecular mechanisms of the E99K mutation in cardiac actin (ACTC GENE) that causes apical hypertrophy in man and mouse.
Song W, Dyer E, Stuckey DJ, Copeland O’N, Leung M-C, Bayliss C, Messer A, Wilkinson R, Lopez Tremoleda J, Schneider MD, Harding SE, Redwood CS, Clarke K, Nowak K, Monserrat L, Wells D, Marston SB.
J Biol Chem. 2011 Aug 5;286(31):27582-93. doi: 10.1074/jbc.M111.252320. PubMed PMID: 21622575

Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1: A Novel Mode of NF-B Regulation That Promotes Arterial Inflammation.

Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R, Evans PC.
Circ Res. 2011 Apr 15;108(8):950-9. doi: 10.1161/CIRCRESAHA.110.233841. PubMed PMID: 21350211

Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1: A Novel Antiinflammatory Treatment for Vein Grafts?
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO, Evans PC. 

Circulation. 2011 Feb 8;123(5):524-32. doi: 10.1161/CIRCULATIONAHA.110.979542. PubMed PMID: 21262999

Maximising efficiency of alternation algorithms for hemodynamic optimisation of the AV delay of cardiac resynchronization therapy.
Whinnett ZI, Nott G, Davies JE, Willson K, Manisty CH, Kanagaratnam P, Peters NS, Davies DW, Hughes AD, Mayet J, Francis DP.
Pacing Clin Electrophysiol. 2011 Feb;34(2):217-25. doi: 10.1111/j.1540-8159.2010.02933.x. PubMed PMID: 21029129

The calcineurin splicing variant CnAβ1 improves cardiac function following myocardial infarction without inducing hypertrophy.
Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, López-Olañeta MM, Gómez-Salinero JM, Suzuki K, Barton P, Rosenthal N, Lara-Pezzi E.
Circulation. 2011 Jun 21;123(24):2838-47. doi: 10.1161/CIRCULATIONAHA.110.012211. PubMed PMID: 21632490

IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines.
Santini MP, Lexow J, Borsellino G, Slonimsky E, Zarrinpashneh E, Poggioli T, Rosenthal N.
Biochem Biophys Res Commun. 2011 Jul 1;410(2):201-7. doi: 10.1016/j.bbrc.2011.05.081. PubMed PMID: 21621517

Cardiac muscle regeneration: lessons from development.
Mercola M, Ruiz-Lozano P, Schneider MD.
Genes Dev. 2011 Feb 15;25(4):299-309. doi: 10.1101/gad.2018411. PubMed PMID: 21325131

Baseline predictors of resistant hypertension in the Anglo-Scandinavian Cardiac Outcome Trial (ASCOT): a risk score to identify those at high-risk.
Gupta AK, Nasothimiou EG, Chang CL, Sever PS, Dahlo B, Poulter NR, on behalf of the ASCOT investigators.
J Hypertens. 2011 Oct;29(10):2004-13. doi: 10.1097/HJH.0b013e32834a8a42. PubMed PMID: 21881528

Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties
.
Vanleene M, Saldanha Z, Cloyd KL, Jell G, Bou-Gharios G, Duncan Bassett JH, Williams GR, Fisk MN, Oyen ML, Stevens MM, Guillot PV, Shefelbine SJ.
Blood. 2011 Jan 20;117(3):1053-60. doi: 10.1182/blood-2010-05-287565. PubMed PMID: 21088133

Role of shear stress in endothelial cell morphology and expression of cyclooxygenase isoforms.
Potter CM, Lundberg MH, Harrington LS, Warboys CM, Warner TD, Berson RE, Moshkov AV, Gorelik J, Weinberg PD, Mitchell JA.
Arterioscler Thromb Vasc Biol. 2011 Feb;31(2):384-91. doi: 10.1161/ATVBAHA.110.214031. PubMed PMID: 21127291

Effect of reverse flow on the pattern of wall shear stress near arterial branches.
Kazakidi A, Plata AM, Sherwin SJ, Weinberg PD.
J R Soc Interface. 2011 Nov 7;8(64):1594-603. doi: 10.1098/rsif.2011.0108. PubMed PMID: 21508011

Blood flow in the rabbit aortic arch and descending thoracic aorta.
Vincent PE, Plata AM, Hunt AAE, Weinberg PD, and Sherwin SJ.
J R Soc Interface. 2011 Dec 7;8(65):1708-19. doi: 10.1098/rsif.2011.0116. PubMed PMID: 21593030

2010 papers

The genome sequence of the spontaneously hypertensive rat: analysis and functional significance.
Atanur SS, Birol I, Guryev V, Hirst M, Hummel O, Morrissey C, Behmoaras J, Fernandez-Suarez XM, Johnson MD, McLaren WM, Patone G, Petretto E, Plessy C, Rockland KS, Rockland C, Saar K, Zhao Y, Carninci P, Flicek P, Kurtz T, Cuppen E, Pravenec M, Hubner N, Jones SJ, Birney E, Aitman TJ.
Genome Res. 2010 Jun;20(6):791-803. doi: 10.1101/gr.103499.109. PubMed PMID: 20430781

Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection.
Plata AM, Sherwin SJ, Krams R.
Ann Biomed Eng. 2010 Sep;38(9):2805-16. doi: 10.1007/s10439-010-0039-x. PubMed PMID: 20390451

The renin-angiotensin system mediates the effects of stretch on conduction velocity, connexin43 expression and redistribution in intact ventricle.
Hussain W, Patel PM, Chowdhury RA, Cabo C, Ciaccio EJ, Lab MJ, Duffy HS, Wit AL, Peters NS.
J Cardiovasc Electrophysiol. 2010 Nov;21(11):1276-83. doi: 10.1111/j.1540-8167.2010.01802.x. PubMed PMID: 20487124

Revealing new mouse epicardial cell markers through transcriptomics.
Bochmann L, Sarathchandra P, Mori F, Lara-Pezzi E, Lazzaro D, Rosenthal N.
PLoS One. 2010 Jun 28;5(6):e11429. doi: 10.1371/journal.pone.0011429. PubMed PMID: 20596535

Serum and Glucocorticoid- inducible Kinase 1 (SGK1) is necessary for vascular remodelling during angiogenesis.
Catela C, Kratsios P, Hede M, Lang F, Rosenthal N.
Dev Dyn. 2010 Aug;239(8):2149-60. doi: 10.1002/dvdy.22345. PubMed PMID: 20568246