A Centre for Complexity Science seminar given by Guillaume Dumas on “Generative Models across Scales: from Precision Medicine to Social Neuroscience”. Please note the unusual starting time.
With the recent development of –omics fields, multiple subdisciplines in life sciences have embraced networks as a valuable formalism. This presentation will present two projects illustrating how –omics networks can be used in biomedical research: 1) whole brain neuro-computational modelling with connectomics, and 2) network-based stratification (NBS) with Genomics. The first example builds on the importance of anatomical and functional interactions in neuroscience; through modelling, numerical simulations provide insight into the basic mechanisms that enable integrative neural processes and how structural brain networks generate spatially and temporally organized brain activity at both intra- and inter-individual levels. The second example was originally designed for cancer research; the NBS combines genetic mutation profiles of patients with protein-protein interaction networks to uncover clusters of patients with similar tumour subtypes. Here we will review the original results through a case study of reproducibility in bioinformatics and then explain the challenges to apply it to autism.