People

Tiago C. Luis, PhD

Tiago Luis

Principal Investigator
Sir Henry Dale Fellow of the Wellcome Trust and The Royal Society

I graduated from the University of Lisbon (Portugal) in 2005 and since then my research has focused on the mechanisms regulating haematopoietic stem cell (HSC) function and the extracellular signals these cells receive from their niche. During my PhD studies in the laboratory of Prof. Frank Staal and Prof. Jacques van Dongen at Erasmus Medical Centre Rotterdam (The Netherlands) I studied the role of the Wnt-signalling pathway in haematopoiesis. I demonstrated a stage/lineage-specific and dosage-dependent effect of Wnt-signalling throughout adult haematopoiesis. After obtaining my PhD in 2010 I joined the laboratory of Prof. Sten Eirik Jacobsen at the University of Oxford (UK) as an EMBO postdoctoral fellow, to investigate the cellular pathways of lineage commitment from HSCs. I characterized the first haematopoietic progenitors that migrate and colonize the foetal thymus, where they encounter a specific microenvironment eliciting further differentiation through the T-lymphocyte lineage. In 2014 I as awarded a Kay Kendall Leukaemia Fund Fellowship to investigate the bone marrow niche of platelet-biased HSCs. 

In 2018 I was awarded a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society to start my laboratory at Imperial College London. My research focuses on the molecular mechanisms by which the bone marrow niche regulates HSCs, in homeostasis and in the development of haematological malignancies.


 Lab Members

KexinKexin Fan

Master Student - MSc Immunology Program

My name is Kexin Fan and I was born in China. For my undergraduate degree, I studied biology in the college of William and Mary in the United States. Now, I am a MSc immunology student and currently work on the hematopoietic stem  cell niche in the Luis lab.

KexinEleanor Hawkins

Master Student - MRes Molecular and Cellular Biosciences Program

More information soon


Join the lab

 

We are recruiting - Postdoctoral Researcher 

 

We are recruiting a highly motivated Postdoctoral Researcher to join the lab and work on an exciting new project funded by the Wellcome Trust and The Royal Society. 

The projects aims at understanding how myeloid leukaemia remodels the haematopoietic stem cell niche to favour leukaemia development. It involves the use of in vivo models of leukaemia development, which will be analysed by cutting edge multi-parameter flow cytometry, single-cell RNA sequencing, imaging of the bone marrow niche and computational/systems biology methods.

Job reference: NAT00474

Closing date: 12 July 2019

To apply and for more information on this post follow this link.

 
We also welcome informal enquiries for other positions. If you are interested in joining the lab please get in touch.