Tiago C. Luis, PhD

Tiago Luis

Principal Investigator
Sir Henry Dale Fellow of the Wellcome Trust and The Royal Society

I graduated from the University of Lisbon (Portugal) in 2005 and since then my research has focused on the mechanisms regulating haematopoietic stem cell (HSC) function and the extracellular signals these cells receive from their niche. During my PhD studies in the laboratory of Prof. Frank Staal and Prof. Jacques van Dongen at Erasmus Medical Centre Rotterdam (The Netherlands) I studied the role of the Wnt-signalling pathway in haematopoiesis. I demonstrated a stage/lineage-specific and dosage-dependent effect of Wnt-signalling throughout adult haematopoiesis. After obtaining my PhD in 2010 I joined the laboratory of Prof. Sten Eirik Jacobsen at the University of Oxford (UK) as an EMBO postdoctoral fellow, to investigate the cellular pathways of lineage commitment from HSCs. I characterized the first haematopoietic progenitors that migrate and colonize the foetal thymus, where they encounter a specific microenvironment eliciting further differentiation through the T-lymphocyte lineage. In 2014 I as awarded a Kay Kendall Leukaemia Fund Fellowship to investigate the bone marrow niche of platelet-biased HSCs. 

In 2018 I was awarded a Sir Henry Dale Fellowship from the Wellcome Trust and the Royal Society to start my laboratory at Imperial College London. My research focuses on the molecular mechanisms by which the bone marrow niche regulates HSCs, in homeostasis and in the development of haematological malignancies.

 Lab Members

MarineMarine Secchi 

PhD Student - Wellcome Trust Program - The Molecular & Cellular Basis of Infection

My name is Marine Secchi, I’m from France. During my MRes I worked on malaria and the T cell response to influenza before diving into the field of haematopoietic stem cells. For my PhD I will look at the bone marrow niche and the molecular mechanisms regulating platelet-biased haematopoietic stem cells in response to platelet-depletion and malaria infection.

VictoireVictoire Boulat

MRes Molecular and Cellular Biosciences

My name is Victoire Boulat, I am French and American. I completed my undergraduate degree in Biological Sciences at Imperial College London. I have carried out two laboratory placements: one at the Francis Crick Institute working on a mouse model of Down Syndrome and one at Imperial College identifying the morphological effect of antimalarial drugs on malaria parasite cells. During my MRes project in the Luis lab, I aim to establish a mouse model to investigate early stages of leukaemia development. 


Join the lab


We welcome informal enquiries about opportunities to work in our team. If you are interested in joining the lab please get in touch.



Past Lab Members

VasilikiVasiliki Symeonidou

Post-doctoral Research Associate - 2020


 KexinKexin Fan

Research Assistant - 2019-2020 / MSc Immunology - 2019



Past Rotation Students

YxuanYxuan Wang

MRes Molecular and Cellular Biosciences - 2020 


Hana DowidarHana Dowidar

Undergraduate Student - BSc Medical Bioscience - 2020


Anu ChahalAnuChahal

Undergraduate Student - BSc Biochemistry - 2020


MarkPailingMark Pailing

MRes Molecular and Cellular Biosciences - 2020 


EleonorEleonor Hawkins

MRes Molecular and Cellular Biosciences - 2019