EPSRC Centre for Mathematics of Precision Healthcare

Precision healthcare seeks to deploy therapies that are sensitive to the particular genetic, lifestyle and environmental circumstances of each patient. Understanding how best to use these numerous features about each patient is a true mathematical challenge.

The EPSRC Centre for Mathematics of Precision Healthcare at Imperial will serve as a focal point by linking up mathematical, computational and medical capabilities at Imperial around the theme of multi-scale networks for data-rich precision healthcare.  

Medicine is undergoing a simultaneous shift at the levels of the individual and the population: we have unprecedented tools for precision monitoring and intervention in individual health, and we also have high-resolution behavioural and social data.

Opportunities

EPSRC Centre for Mathematics of Precision Healthcare Joint PhD studentships

The EPSRC Centre for Mathematics of Precision Healthcare was set up at the end of 2016 and acts as an interface between mathematicians and computational data scientists with clinicians, basic medical scientists and healthcare economists in order to develop novel mathematical techniques to answer key questions in data-rich aspects of healthcare.

A huge amount of detailed healthcare data is becoming available as part of the trend towards data analytics and increasingly personalised patient care, from imaging and ‘omics characterization of disease, to social and economic aspects of public health. to the use of machine learning techniques for patient trajectories or for the analysis of free text in health records. There is huge potential in using this trove of information to help decision making in medicine and healthcare, both at the individual and population levels.

The EPSRC CMPH has a number of PhD studentships available starting in October 2018, where the successful candidates will join a centre of leading PhD students, postdocs and academics across departments at Imperial to develop the mathematical and algorithmic foundations around Machine learning, Data Science, Inference and Optimization, Network Science, and Artificial Intelligence in healthcare and medicine to help unlock this information. 

You should have an excellent academic record and passion for applied mathematics and modern computational and statistical methods.

We seek students that are open-minded, creative and willing to explore new ideas as part of a multidisciplinary team but at the same time committed to developing methods that are generic and transferable. The candidate should have excellent mathematical and computational skills, as well as outstanding presentation skills for various audiences. It is expected that candidates hold (or be near completion of) a top undergraduate degree in mathematics, physics, computer science, engineering, or equivalent quantitative backgrounds. The PhD positions will be based in the Department of Mathematics but will be highly collaborative.

 

Below we summarise three PhD projects that are currently available but the Centre is expected to appoint/host several additional PhD students in the broad areas described above. The positions only cover UK/EU fees.

To apply and for enquires please contact Dr Chloe Stockford (chloe.stockfor@imperial.ac.uk) and Prof Mauricio Barahona (m.barahona@imperial.ac.uk).

 

Applications should include a CV and names of two referees.

 

EPSRC Centre of Precision Healthcare joint with Cancer Research UK PhD Studentship in Network Cancer Medicine

 

Title: "Tracking the metabolic footprints of cancer using network analysis"

 

We have an exciting opportunity for a student who wishes to work at the interface of cancer biology, network theory and data science. The project is part of a thriving collaboration between the Biomathematics Group (D Oyarzún, M Barahona) and the Cancer Metabolism & Systems Toxicology Group (H Keun) at Imperial College London. The student will be based at EPSRC Centre for Mathematics of Precision Healthcare in South Kensington, at the heart of London's cultural and scientific quarter.

 

Description - Abnormal metabolism is a hallmark of cancer cells. Yet the complex connectivity of metabolic networks makes it difficult to establish how misregulation of specific pathways translates into malignant phenotypes. In this project we will study metabolism of tumour cells with a mix of network theory and high-dimensional data analysis. We will build graph models from genome-scale metabolic reconstructions and interrogate them with the various tools from network science, such as centrality analyses, graph embeddings and community detection.

 

The goal is to capture systemic changes in metabolic network for various environmental conditions and genetic alterations, so as to find new drug targets and biomarkers for tumour malignancy. Models will be refined with available omics datasets, together with cutting-edge metabolomics/fluxomics data from the Keun lab at the Department of Surgery & Cancer. We will test the novel therapeutic interventions with various interference experiments (siRNA, shRNA/CRISPR, small molecule inhibitors) in specific tumour cell models.

 

This is a well funded 4-year position for UK or EU nationals, co-funded by the Imperial College Cancer Research UK Centre and the EPSRC Centre for Mathematics of Precision Healthcare. The student will benefit from the thriving environment of the CMPH composed of mathematicians, clinicians and public health specialists working on data-based solutions for healthcare. This will also afford the student close contact with end users and industrial partners developing personalised cancer diagnostics and therapeutics. Experience with cancer biology and/or flux balance analysis would be advantageous.

 

EPSRC Centre of Precision Healthcare joint with Institute of Global Health Innovation PhD studentship

 

 

This PhD project is a collaboration between CMPH and the Institute of Global Health Innovation (IGHI). IGHI provides an extensive platform for collaborations with healthcare institutions, practitioners and medics within Imperial, the NHS and international partners. The Institute covers a broad spectrum of areas from organizational aspects of healthcare provision (patient safety, patient flows in hospitals, patient-sharing networks, socio-economic aspects of health provision, social media in healthcare) to areas of the adoption of innovation in healthcare to decision-making in public health and healthcare provision.

 

This project will focus on developing mathematical and computational frameworks for patient safety, patient flows, innovation adoption, social media and decision-making, utilizing big data in healthcare. The techniques are diverse but will likely include graphs, stochastic processes, machine learning, inference and optimization.

 

This project will be funded for 3.5 years and is open to UK/ EU nationals.

 

 

EPSRC Centre of Precision Healthcare joint with Medical Research Council Doctoral  Training Council PhD Studentship

 

This is an open-ended project to be developed in collaboration with the MRC DTP (Medical Research Council Doctoral Training Partnership).  The project will focus on mathematical and computational techniques in the general areas of medical research from modelling to data integration, imaging, modelling of infectious disease, early and enhanced discovery in disease, patient stratification, social aspects of disease, or personalisation of therapy.

 

The student will be based in the Department of Mathematics and the EPSRC CMPH but will also be integral part of the MRC DTP cohort, thus allowing for the integration with a multidisciplinary group of students.

 

This project will be funded for 3.5 years and is open to UK/EU nationals that fulfill the UK residency requirement (3 years in the UK).

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