Imperial College London
Alternate

DrArmandoDel Rio Hernandez

Faculty of Engineering, Department of Bioengineering

Reader in Cellular and Molecular Mechanotransduction
 
 
 
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Contact

 

+44 (0)20 7594 5187a.del-rio-hernandez

 
 
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Location

 

308Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rice:2017:10.1038/oncsis.2017.54,
author = {Rice, AJ and Cortes, E and Lachowski, D and Cheung, BCH and Karim, SA and Morton, JP and Del, Río Hernández A},
doi = {10.1038/oncsis.2017.54},
journal = {Oncogenesis},
pages = {e352--e352},
title = {Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells},
url = {http://dx.doi.org/10.1038/oncsis.2017.54},
volume = {6},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival and tumour growth. Pancreatic cancer is one of the stiffest of all human solid carcinomas and is characterised by a remarkable desmoplastic reaction. Here we use mouse models, genetically engineered to recapitulate human pancreatic cancer, and several pancreatic cancer cell lines as a model to investigate the effect of matrix stiffness in epithelial-mesenchymal transition (EMT) and resistance to chemotherapeutics. We found that recapitulation of the fibrotic rigidities found in pancreatic cancer tissues promote elements of EMT, including increases in vimentin expression, decreases in E-cadherin expression, nuclear localisation of β-catenin, YAP and TAZ and changes in cell shape towards a mesenchymal phenotype. We also report that stiffness induces chemoresistance to paclitaxel, but not to gemcitabine, both commonly used therapeutics, suggesting that environmental rigidity underlies an aspect of chemoresistance.
AU  - Rice,AJ
AU  - Cortes,E
AU  - Lachowski,D
AU  - Cheung,BCH
AU  - Karim,SA
AU  - Morton,JP
AU  - Del,Río Hernández A
DO  - 10.1038/oncsis.2017.54
EP  - 352
PY  - 2017///
SN  - 2157-9024
SP  - 352
TI  - Matrix stiffness induces epithelial-mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
T2  - Oncogenesis
UR  - http://dx.doi.org/10.1038/oncsis.2017.54
UR  - http://hdl.handle.net/10044/1/50644
VL  - 6
ER  -
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