Imperial College London
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DrAdamFrampton

Faculty of Medicine, Department of Surgery & Cancer

Honorary Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 2125a.frampton

 
 
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Location

 

4005Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lemanska:2023:10.7554/eLife.85332,
author = {Lemanska, A and Andrews, C and Fisher, L and Bacon, S and Frampton, AE and Mehrkar, A and Inglesby, P and Davy, S and Roberts, K and Patalay, P and Goldacre, B and MacKenna, B and OpenSAFELY, Collaborative and Walker, AJ},
doi = {10.7554/eLife.85332},
journal = {Elife},
title = {Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP.},
url = {http://dx.doi.org/10.7554/eLife.85332},
volume = {12},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Healthcare across all sectors, in the UK and globally, was negatively affected by the COVID-19 pandemic. We analysed healthcare services delivered to people with pancreatic cancer from January 2015 to March 2023 to investigate the effect of the COVID-19 pandemic. METHODS: With the approval of NHS England, and drawing from a nationally representative OpenSAFELY-TPP dataset of 24 million patients (over 40% of the English population), we undertook a cohort study of people diagnosed with pancreatic cancer. We queried electronic healthcare records for information on the provision of healthcare services across the pancreatic cancer pathway. To estimate the effect of the COVID-19 pandemic, we predicted the rates of healthcare services if the pandemic had not happened. We used generalised linear models and the pre-pandemic data from January 2015 to February 2020 to predict rates in March 2020 to March 2023. The 95% confidence intervals of the predicted values were used to estimate the significance of the difference between the predicted and observed rates. RESULTS: The rate of pancreatic cancer and diabetes diagnoses in the cohort was not affected by the pandemic. There were 26,840 people diagnosed with pancreatic cancer from January 2015 to March 2023. The mean age at diagnosis was 72 (±11 SD), 48% of people were female, 95% were of White ethnicity, and 40% were diagnosed with diabetes. We found a reduction in surgical resections by 25-28% during the pandemic. In addition, 20%, 10%, and 4% fewer people received body mass index, glycated haemoglobin, and liver function tests, respectively, before they were diagnosed with pancreatic cancer. There was no impact of the pandemic on the number of people making contact with primary care, but the number of contacts increased on average by 1-2 per person amongst those who made contact. Reporting of jaundice decreased by 28%, but recovered within 12 months into the pandemic. Emergency department visits, hospital a
AU  - Lemanska,A
AU  - Andrews,C
AU  - Fisher,L
AU  - Bacon,S
AU  - Frampton,AE
AU  - Mehrkar,A
AU  - Inglesby,P
AU  - Davy,S
AU  - Roberts,K
AU  - Patalay,P
AU  - Goldacre,B
AU  - MacKenna,B
AU  - OpenSAFELY,Collaborative
AU  - Walker,AJ
DO  - 10.7554/eLife.85332
PY  - 2023///
TI  - Healthcare in England was affected by the COVID-19 pandemic across the pancreatic cancer pathway: A cohort study using OpenSAFELY-TPP.
T2  - Elife
UR  - http://dx.doi.org/10.7554/eLife.85332
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37561116
VL  - 12
ER  -
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