Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Laiyemo:2011:10.1016/j.gie.2011.02.023,
author = {Laiyemo, AO and Doubeni, C and Sanderson, AK and Pinsky, PF and Badurdeen, DS and Doria-Rose, VP and Marcus, PM and Schoen, RE and Lanza, E and Schatzkin, A and Cross, AJ},
doi = {10.1016/j.gie.2011.02.023},
journal = {Gastrointest Endosc},
pages = {253--261},
title = {Likelihood of missed and recurrent adenomas in the proximal versus the distal colon.},
url = {http://dx.doi.org/10.1016/j.gie.2011.02.023},
volume = {74},
year = {2011}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Colonoscopy may be less efficacious in reducing colorectal cancer mortality in the proximal compared with the distal colon. A greater likelihood for missed and recurrent adenomas in the proximal colon may contribute to this phenomenon. OBJECTIVE: To examine whether a proximal adenoma is associated with the risk and location of missed and recurrent adenomas. DESIGN: Prospective. SETTING: Polyp Prevention Trial. PARTICIPANTS: A total of 1864 patients with an adenoma at baseline underwent a follow-up colonoscopy 4 years later (adenoma recurrence). Of these, 1731 underwent a clearing colonoscopy 1 year after the baseline examination (missed adenoma). MAIN OUTCOME MEASUREMENTS: Association of baseline adenoma location with the risk and location of adenomas found at colonoscopy performed 1 year and 4 years later. RESULTS: At the year 1 colonoscopy, 598 patients (34.6%) had an adenoma (missed adenoma). Compared with those with a distal-only adenoma at baseline, patients with a proximal-only adenoma at baseline were more likely to have any missed adenomas (relative risk [RR] 1.28; 95% CI, 1.09-1.49) and a proximal-only missed adenoma (RR 2.05; 95% CI, 1.49-2.80). At the year 4 colonoscopy, 733 patients (39.3%) had adenoma recurrence. Patients with a baseline proximal-only adenoma were more likely to have any adenoma recurrence (RR 1.14; 95% CI, 1.00-1.31) and a proximal-only adenoma recurrence (RR 1.52; 95% CI, 1.15-2.02). Sensitivity analyses involving missed adenomas did not materially affect the risk or location of recurrent adenomas at year 4 colonoscopy. LIMITATION: Lesions may still be missed on repeated colonoscopies. CONCLUSIONS: Missed and recurrent adenomas are more likely to be in the proximal colon.
AU  - Laiyemo,AO
AU  - Doubeni,C
AU  - Sanderson,AK
AU  - Pinsky,PF
AU  - Badurdeen,DS
AU  - Doria-Rose,VP
AU  - Marcus,PM
AU  - Schoen,RE
AU  - Lanza,E
AU  - Schatzkin,A
AU  - Cross,AJ
DO  - 10.1016/j.gie.2011.02.023
EP  - 261
PY  - 2011///
SP  - 253
TI  - Likelihood of missed and recurrent adenomas in the proximal versus the distal colon.
T2  - Gastrointest Endosc
UR  - http://dx.doi.org/10.1016/j.gie.2011.02.023
UR  - https://www.ncbi.nlm.nih.gov/pubmed/21549375
VL  - 74
ER  -
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