Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
//

Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
//

Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Keimling:2013:10.1158/1055-9965.EPI-13-0353,
author = {Keimling, M and Renehan, AG and Behrens, G and Fischer, B and Hollenbeck, AR and Cross, AJ and Leitzmann, MF},
doi = {10.1158/1055-9965.EPI-13-0353},
journal = {Cancer Epidemiol Biomarkers Prev},
pages = {1383--1394},
title = {Comparison of associations of body mass index, abdominal adiposity, and risk of colorectal cancer in a large prospective cohort study.},
url = {http://dx.doi.org/10.1158/1055-9965.EPI-13-0353},
volume = {22},
year = {2013}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Increased body mass index (BMI) is an established colorectal cancer risk factor. High waist circumference or waist-hip-ratio (WHR) may better reflect an abnormal metabolic state and be more predictive of colorectal cancer risk than BMI. METHODS: We examined BMI, waist circumference, WHR, and hip circumference in relation to colorectal cancer risk among 203,177 participants followed for 10 years. We derived standardized colorectal cancer risk estimates for each anthropometric parameter and compared predictive characteristics (Harrell's C-index). In women, we examined whether hormone replacement therapy (HRT) use modified the associations between anthropometric measures and colorectal cancer. RESULTS: We ascertained 2,869 colorectal cancers. In men, increased colon cancer risks were associated with BMI [HR per SD, 1.14; 95% confidence interval (CI), 1.08-1.20], waist circumference (HR per SD, 1.17; 95% CI, 1.08-1.27), and WHR (HR per SD, 1.09; 95% CI, 1.04-1.14). In women, anthropometric variables were unrelated to colon cancer. For men and women, anthropometric variables were unrelated to rectal cancer. Compared with BMI, waist circumference and WHR did not materially influence colon cancer prediction models [C-index changes: -0.0041 and 0.0046 (men); 0.0004 and 0.0005 (women)]. In current HRT users, colon cancer was inversely or suggestively inversely associated with waist circumference (HR per SD, 0.78; 95% CI, 0.63-0.97) and WHR (HR per SD, 0.88; 95% CI, 0.76-1.01), but positively related to hip circumference (HR per SD, 1.39; 95% CI, 1.13-1.71). CONCLUSION: BMI, waist circumference, and WHR show comparable positive associations with colon cancer in men. Associations between anthropometric measures and colon cancer are weak or null in women, but there is some evidence for effect modification by HRT. IMPACT: These findings may improve our understanding of the relation of adiposity to colorectal cancer.
AU  - Keimling,M
AU  - Renehan,AG
AU  - Behrens,G
AU  - Fischer,B
AU  - Hollenbeck,AR
AU  - Cross,AJ
AU  - Leitzmann,MF
DO  - 10.1158/1055-9965.EPI-13-0353
EP  - 1394
PY  - 2013///
SP  - 1383
TI  - Comparison of associations of body mass index, abdominal adiposity, and risk of colorectal cancer in a large prospective cohort study.
T2  - Cancer Epidemiol Biomarkers Prev
UR  - http://dx.doi.org/10.1158/1055-9965.EPI-13-0353
UR  - https://www.ncbi.nlm.nih.gov/pubmed/23720402
VL  - 22
ER  -
Download