Imperial College London
Alternate

Dr Becca Asquith

Faculty of Medicine, Department of Infectious Disease

Professor of Mathematical Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3731b.asquith

 
 
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Location

 

112Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Debebe:2020:10.7554/eLife.54558,
author = {Debebe, BJ and Boelen, L and Lee, JC and IAVI, Protocol C Investigators and Thio, CL and Astemborski, J and Kirk, G and Khakoo, SI and Donfield, SM and Goedert, JJ and Asquith, B},
doi = {10.7554/eLife.54558},
journal = {eLife},
pages = {1--43},
title = {Identifying the immune interactions underlying HLA class I disease associations},
url = {http://dx.doi.org/10.7554/eLife.54558},
volume = {9},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms in the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8+ T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound by HLA class I molecules, alternative interpretations are possible. As well as binding T cell receptors on CD8+ T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobulin-like receptors (KIRs) which are found on natural killer cells and some T cells; for the CD94:NKG2 family of receptors also expressed mainly by NK cells and for leukocyte immunoglobulin-like receptors (LILRs) on myeloid cells. The aim of this study is to develop an immunogenetic approach for identifying and quantifying the relative contribution of different receptor-ligand interactions to a given HLA class I disease association and then to use this approach to investigate the immune interactions underlying HLA class I disease associations in three viral infections: Human T cell Leukemia Virus type 1, Human Immunodeficiency Virus type 1 and Hepatitis C Virus as well as in the inflammatory condition Crohn's disease.
AU  - Debebe,BJ
AU  - Boelen,L
AU  - Lee,JC
AU  - IAVI,Protocol C Investigators
AU  - Thio,CL
AU  - Astemborski,J
AU  - Kirk,G
AU  - Khakoo,SI
AU  - Donfield,SM
AU  - Goedert,JJ
AU  - Asquith,B
DO  - 10.7554/eLife.54558
EP  - 43
PY  - 2020///
SN  - 2050-084X
SP  - 1
TI  - Identifying the immune interactions underlying HLA class I disease associations
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.54558
UR  - https://elifesciences.org/articles/54558
UR  - http://hdl.handle.net/10044/1/78725
VL  - 9
ER  -
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