Imperial College London
Alternate

Dr Becca Asquith

Faculty of Medicine, Department of Infectious Disease

Professor of Mathematical Immunology
 
 
 
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Contact

 

+44 (0)20 7594 3731b.asquith

 
 
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Location

 

112Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{B:2006:10.1371/journal.pbio.0040090,
author = {B, Asquith and C, Edwards and M, Lipsitch and A, McLean},
doi = {10.1371/journal.pbio.0040090},
journal = {PLoS Biology},
pages = {583--592},
title = {Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo},
url = {http://dx.doi.org/10.1371/journal.pbio.0040090},
volume = {4},
year = {2006}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Understanding the role of cytotoxic T lymphocytes (CTLs) in controlling HIV-1 infection is vital for vaccine design. However, it is difficult to assess the importance of CTLs in natural infection. Different human leukocyte antigen (HLA) class I alleles are associated with different rates of progression to AIDS, indicating that CTLs play a protective role. Yet virus clearance rates following antiretroviral therapy are not impaired in individuals with advanced HIV disease, suggesting that weakening of the CTL response is not the major underlying cause of disease progression and that CTLs do not have an important protective role. Here we reconcile these apparently conflicting studies. We estimate the selection pressure exerted by CTL responses that drive the emergence of immune escape variants, thereby directly quantifying the efficiency of HIV-1–specific CTLs in vivo. We estimate that only 2% of productively infected CD4+ cell death is attributable to CTLs recognising a single epitope. We suggest that CTLs kill a large number of infected cells (about 107) per day but are not responsible for the majority of infected cell death.
AU  - B,Asquith
AU  - C,Edwards
AU  - M,Lipsitch
AU  - A,McLean
DO  - 10.1371/journal.pbio.0040090
EP  - 592
PY  - 2006///
SN  - 1544-9173
SP  - 583
TI  - Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo
T2  - PLoS Biology
UR  - http://dx.doi.org/10.1371/journal.pbio.0040090
UR  - https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.0040090
UR  - http://hdl.handle.net/10044/1/77259
VL  - 4
ER  -
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