Imperial College London

Dr. Beth Holder

Faculty of MedicineDepartment of Medicine

Research Associate



+44 (0)20 7594 2063b.holder




235Wright Fleming WingSt Mary's Campus





The MatImms study is a study into the impact of maternal pertussis and flu vaccination on neonatal and early-life immune responses. We are recruiting both vaccinated and unvaccinated mothers and collecting maternal and infant blood samples. We are using these samples to investigate both antibody and cell-mediated immune responses to vaccination, and its impact on responses to subsequent vaccinations in the infant.

Trans-placental exosome transfer

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Beth's primary research focus is invesigating the bi-directional trafficking of exosomes between the mother and the feto-placental unit. Current research has previously focused on trafficking from the placenta to the mother. Beth has recently published the first demonstration of trafficking of exosomes from immune cells to the placenta. This is also the first demonstration of uptake of heterologous exosomes by the human placenta. This study demonstrated that uptake occurs by clathrin-mediated endocytosis, and induces the release of placental pro- and anti-inflammtory cytokines. Current and future work is continuing this research in more detail.


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Dr. Paul Brownbill, The University of Manchester, 2014

Dr. Lynda Harris, The University of Manchester, 2014

Dr. Karen Forbes, The University of Manchester

Guest Lectures

Liverpool University Exosome Workshop, The University of Liverpool, 2016

Research Staff


Research Student Supervision

Rice,T, Impact of maternal pertussis vaccination on the development of the innate and adaptive infant immune system’