Imperial College London
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Professor Christl Donnelly CBE FMedSci FRS

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.donnelly Website

 
 
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Location

 

School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ward:2023:10.2105/AJPH.2023.307381,
author = {Ward, H and Atchison, C and Whitaker, M and Davies, B and Ashby, D and Darzi, A and Chadeau-Hyam, M and Riley, S and Donnelly, CA and Barclay, W and Cooke, GS and Elliott, P},
doi = {10.2105/AJPH.2023.307381},
journal = {American Journal of Public Health},
pages = {e1--e9},
title = {Design and implementation of a national program to monitor the prevalence of SARS-CoV-2 IgG antibodies in England using self-testing: the REACT-2 study},
url = {http://dx.doi.org/10.2105/AJPH.2023.307381},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Data System. The UK Department of Health and Social Care funded the REal-time Assessment of Community Transmission-2 (REACT-2) study to estimate community prevalence of SARS-CoV-2 IgG (immunoglobulin G) antibodies in England. Data Collection/Processing. We obtained random cross-sectional samples of adults from the National Health Service (NHS) patient list (near-universal coverage). We sent participants a lateral flow immunoassay (LFIA) self-test, and they reported the result online. Overall, 905 991 tests were performed (28.9% response) over 6 rounds of data collection (June 2020-May 2021). Data Analysis/Dissemination. We produced weighted estimates of LFIA test positivity (validated against neutralizing antibodies), adjusted for test performance, at local, regional, and national levels and by age, sex, and ethnic group and area-level deprivation score. In each round, fieldwork occurred over 2 weeks, with results reported to policymakers the following week. We disseminated results as preprints and peer-reviewed journal publications. Public Health Implications. REACT-2 estimated the scale and variation in antibody prevalence over time. Community self-testing and -reporting produced rapid insights into the changing course of the pandemic and the impact of vaccine rollout, with implications for future surveillance. (Am J Public Health. Published online ahead of print September 21, 2023:e1-e9. https://doi.org/10.2105/AJPH.2023.307381).
AU  - Ward,H
AU  - Atchison,C
AU  - Whitaker,M
AU  - Davies,B
AU  - Ashby,D
AU  - Darzi,A
AU  - Chadeau-Hyam,M
AU  - Riley,S
AU  - Donnelly,CA
AU  - Barclay,W
AU  - Cooke,GS
AU  - Elliott,P
DO  - 10.2105/AJPH.2023.307381
EP  - 9
PY  - 2023///
SN  - 0090-0036
SP  - 1
TI  - Design and implementation of a national program to monitor the prevalence of SARS-CoV-2 IgG antibodies in England using self-testing: the REACT-2 study
T2  - American Journal of Public Health
UR  - http://dx.doi.org/10.2105/AJPH.2023.307381
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37733993
UR  - https://ajph.aphapublications.org/doi/abs/10.2105/AJPH.2023.307381
ER  -
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