Imperial College London
Alternate

ProfessorChristopheFraser

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

c.fraser Website

 
 
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Location

 

G28Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Tostevin:2017:10.1111/hiv.12414,
author = {Tostevin, A and White, E and Dunn, D and Croxford, S and Delpech, V and Williams, I and Asboe, D and Pozniak, A and Churchill, D and Geretti, AM and Pillay, D and Sabin, C and Leigh-Brown, A and Smit, E},
doi = {10.1111/hiv.12414},
journal = {HIV Medicine},
pages = {204--213},
title = {Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom},
url = {http://dx.doi.org/10.1111/hiv.12414},
volume = {18},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesTransmission of drugresistant HIV1 has decreased in the UK since the early 2000s. This analysis reports recent trends and characteristics of transmitted drug resistance (TDR) in the UK from 2010 to 2013.MethodsResistance tests conducted in antiretroviral treatment (ART)naïve individuals between 2010 and 2013 were analysed for the presence of transmitted drug resistance mutations (TDRMs), defined as any mutations from a modified 2009 World Health Organization surveillance list, or a modified 2013 International Antiviral SocietyUSA list for integrase tests. Logistic regression was used to examine associations between demographics and the prevalence of TDRMs.ResultsTDRMs were observed in 1223 (7.5%) of 16 425 individuals; prevalence declined from 8.1% in 2010 to 6.6% in 2013 (P = 0.02). The prevalence of TDRMs was higher among men who have sex with men (MSM) compared with heterosexual men and women (8.7% versus 6.4%, respectively) with a trend for decreasing TDRMs among MSM (P = 0.008) driven by a reduction in nucleoside reverse transcriptase inhibitor (NRTI)related mutations. The most frequently detected TDRMs were K103N (2.2%), T215 revertants (1.6%), M41L (0.9%) and L90M (0.7%). Predicted phenotypic resistance to firstline ART was highest to the nonnucleoside reverse transcriptase inhibitors (NNRTIs) rilpivirine and efavirenz (6.2% and 3.4%, respectively) but minimal to NRTIs, including tenofovir, and protease inhibitors (PIs). No major integrase TDRMs were detected among 101 individuals tested while ARTnaïve.ConclusionsWe observed a decrease in TDRMs in recent years. However, this was confined to the MSM population and rates remained stable in those with heterosexually acquired HIV infection. Resistance to currently recommended firstline ART, including integrase inhibitors, remained reassuringly low.
AU  - Tostevin,A
AU  - White,E
AU  - Dunn,D
AU  - Croxford,S
AU  - Delpech,V
AU  - Williams,I
AU  - Asboe,D
AU  - Pozniak,A
AU  - Churchill,D
AU  - Geretti,AM
AU  - Pillay,D
AU  - Sabin,C
AU  - Leigh-Brown,A
AU  - Smit,E
DO  - 10.1111/hiv.12414
EP  - 213
PY  - 2017///
SN  - 1464-2662
SP  - 204
TI  - Recent trends and patterns in HIV-1 transmitted drug resistance in the United Kingdom
T2  - HIV Medicine
UR  - http://dx.doi.org/10.1111/hiv.12414
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000393907300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/69585
VL  - 18
ER  -
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