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@article{Monod:2024:10.1038/s41564-023-01530-8,
author = {Monod, M and Brizzi, A and Galiwango, RM and Ssekubugu, R and Chen, Y and Xi, X and Kankaka, EN and Ssempijja, V and Abeler-Dörner, L and Akullian, A and Blenkinsop, A and Bonsall, D and Chang, LW and Dan, S and Fraser, C and Golubchik, T and Gray, RH and Hall, M and Jackson, JC and Kigozi, G and Laeyendecker, O and Mills, LA and Quinn, TC and Reynolds, SJ and Santelli, J and Sewankambo, NK and Spencer, SEF and Ssekasanvu, J and Thomson, L and Wawer, MJ and Serwadda, D and Godfrey-Faussett, P and Kagaayi, J and Grabowski, MK and Ratmann, O and Rakai, Health Sciences Program and PANGEA-HIV, consortium},
doi = {10.1038/s41564-023-01530-8},
journal = {Nature Microbiology},
pages = {35--54},
title = {Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda},
url = {http://dx.doi.org/10.1038/s41564-023-01530-8},
volume = {9},
year = {2024}
}

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TY  - JOUR
AB  - HIV incidence in eastern and southern Africa has historically been concentrated among girls and women aged 15-24 years. As new cases decline with HIV interventions, population-level infection dynamics may shift by age and gender. Here, we integrated population-based surveillance of 38,749 participants in the Rakai Community Cohort Study and longitudinal deep-sequence viral phylogenetics to assess how HIV incidence and population groups driving transmission have changed from 2003 to 2018 in Uganda. We observed 1,117 individuals in the incidence cohort and 1,978 individuals in the transmission cohort. HIV viral suppression increased more rapidly in women than men, however incidence declined more slowly in women than men. We found that age-specific transmission flows shifted: whereas HIV transmission to girls and women (aged 15-24 years) from older men declined by about one-third, transmission to women (aged 25-34 years) from men that were 0-6 years older increased by half in 2003 to 2018. Based on changes in transmission flows, we estimated that closing the gender gap in viral suppression could have reduced HIV incidence in women by half in 2018. This study suggests that HIV programmes to increase HIV suppression in men are critical to reduce incidence in women, close gender gaps in infection burden and improve men's health in Africa.
AU  - Monod,M
AU  - Brizzi,A
AU  - Galiwango,RM
AU  - Ssekubugu,R
AU  - Chen,Y
AU  - Xi,X
AU  - Kankaka,EN
AU  - Ssempijja,V
AU  - Abeler-Dörner,L
AU  - Akullian,A
AU  - Blenkinsop,A
AU  - Bonsall,D
AU  - Chang,LW
AU  - Dan,S
AU  - Fraser,C
AU  - Golubchik,T
AU  - Gray,RH
AU  - Hall,M
AU  - Jackson,JC
AU  - Kigozi,G
AU  - Laeyendecker,O
AU  - Mills,LA
AU  - Quinn,TC
AU  - Reynolds,SJ
AU  - Santelli,J
AU  - Sewankambo,NK
AU  - Spencer,SEF
AU  - Ssekasanvu,J
AU  - Thomson,L
AU  - Wawer,MJ
AU  - Serwadda,D
AU  - Godfrey-Faussett,P
AU  - Kagaayi,J
AU  - Grabowski,MK
AU  - Ratmann,O
AU  - Rakai,Health Sciences Program
AU  - PANGEA-HIV,consortium
DO  - 10.1038/s41564-023-01530-8
EP  - 54
PY  - 2024///
SN  - 2058-5276
SP  - 35
TI  - Longitudinal population-level HIV epidemiologic and genomic surveillance highlights growing gender disparity of HIV transmission in Uganda
T2  - Nature Microbiology
UR  - http://dx.doi.org/10.1038/s41564-023-01530-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38052974
UR  - http://hdl.handle.net/10044/1/109059
VL  - 9
ER  -

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