Imperial College London
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ProfessorDannyAltmann

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3313 8212d.altmann

 
 
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Location

 

5S5CHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Astbury:2022:10.1111/imm.13450,
author = {Astbury, S and Reynolds, CJ and Butler, DK and Munoz-Sandoval, DC and Lin, K-M and Pieper, FP and Otter, A and Kouraki, A and Cusin, L and Nightingale, J and Vijay, A and Craxford, S and Aithal, GP and Tighe, PJ and Gibbons, JM and Pade, C and Joy, G and Maini, M and Chain, B and Semper, A and Brooks, T and Ollivere, BJ and McKnight, A and Noursadeghi, M and Treibel, TA and Manisty, C and Moon, JC and Valdes, AM and Boyton, RJ and Altmann, DM},
doi = {10.1111/imm.13450},
journal = {Immunology},
pages = {68--77},
title = {HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19},
url = {http://dx.doi.org/10.1111/imm.13450},
volume = {166},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - SARS-CoV-2 infection results in different outcomes ranging from asymptomatic infection to mild or severe disease and death. Reasons for this diversity of outcome include differences in challenge dose, age, gender, comorbidity and host genomic variation. Human leukocyte antigen (HLA) polymorphisms may influence immune response and disease outcome. We investigated the association of HLAII alleles with case definition symptomatic COVID-19, virus-specific antibody and T-cell immunity. A total of 1364 UK healthcare workers (HCWs) were recruited during the first UK SARS-CoV-2 wave and analysed longitudinally, encompassing regular PCR screening for infection, symptom reporting, imputation of HLAII genotype and analysis for antibody and T-cell responses to nucleoprotein (N) and spike (S). Of 272 (20%) HCW who seroconverted, the presence of HLA-DRB113:02 was associated with a 6·7-fold increased risk of case definition symptomatic COVID-19. In terms of immune responsiveness, HLA-DRB115:02 was associated with lower nucleocapsid T-cell responses. There was no association between DRB1 alleles and anti-spike antibody titres after two COVID vaccine doses. However, HLA DRB115:01 was associated with increased spike T-cell responses following both first and second dose vaccination. Trial registration: NCT04318314 and ISRCTN15677965.
AU  - Astbury,S
AU  - Reynolds,CJ
AU  - Butler,DK
AU  - Munoz-Sandoval,DC
AU  - Lin,K-M
AU  - Pieper,FP
AU  - Otter,A
AU  - Kouraki,A
AU  - Cusin,L
AU  - Nightingale,J
AU  - Vijay,A
AU  - Craxford,S
AU  - Aithal,GP
AU  - Tighe,PJ
AU  - Gibbons,JM
AU  - Pade,C
AU  - Joy,G
AU  - Maini,M
AU  - Chain,B
AU  - Semper,A
AU  - Brooks,T
AU  - Ollivere,BJ
AU  - McKnight,A
AU  - Noursadeghi,M
AU  - Treibel,TA
AU  - Manisty,C
AU  - Moon,JC
AU  - Valdes,AM
AU  - Boyton,RJ
AU  - Altmann,DM
DO  - 10.1111/imm.13450
EP  - 77
PY  - 2022///
SN  - 0019-2805
SP  - 68
TI  - HLA-DR polymorphism in SARS-CoV-2 infection and susceptibility to symptomatic COVID-19
T2  - Immunology
UR  - http://dx.doi.org/10.1111/imm.13450
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000766016000001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/10.1111/imm.13450
UR  - http://hdl.handle.net/10044/1/99210
VL  - 166
ER  -
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