Imperial College London
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ProfessorDannyAltmann

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 3313 8212d.altmann

 
 
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Location

 

5S5CHammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{de:2022:10.1038/s41598-022-20062-5,
author = {de, Morais Batista F and Puga, MAM and da, Silva PV and Oliveira, R and Dos, Santos PCP and da, Silva BO and Tatara, MB and Tsuha, DH and Dos, Santos Pires MA and Gonçalves, CCM and Pessoa, E Silva R and Ferreira, NT and de, Barros Albuquerque AP and da, Silva Duarte G and Consolaro, MEL and Negrão, FJ and Ferrari, IC and de, Goes Cavalcanti LP and Trinta, KS and Ribeiro, GS and de, Melo Rêgo MJB and Boyton, RJ and Siqueira, AM and Altmann, DM and Croda, J},
doi = {10.1038/s41598-022-20062-5},
journal = {Scientific Reports},
title = {Serum biomarkers associated with SARS-CoV-2 severity},
url = {http://dx.doi.org/10.1038/s41598-022-20062-5},
volume = {12},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Immunity with SARS-CoV-2 infection during the acute phase is not sufficiently well understood to differentiate mild from severe cases and identify prognostic markers. We evaluated the immune response profile using a total of 71 biomarkers in sera from patients with SARS-CoV-2 infection, confirmed by RT-PCR and controls. We correlated biological marker levels with negative control (C) asymptomatic (A), nonhospitalized (mild cases-M), and hospitalized (severe cases-S) groups. Among angiogenesis markers, we identified biomarkers that were more frequently elevated in severe cases when compared to the other groups (C, A, and M). Among cardiovascular diseases, there were biomarkers with differences between the groups, with D-dimer, GDF-15, and sICAM-1 higher in the S group. The levels of the biomarkers Myoglobin and P-Selectin were lower among patients in group M compared to those in groups S and A. Important differences in cytokines and chemokines according to the clinical course were identified. Severe cases presented altered levels when compared to group C. This study helps to characterize biological markers related to angiogenesis, growth factors, heart disease, and cytokine/chemokine production in individuals infected with SARS-CoV-2, offering prognostic signatures and a basis for understanding the biological factors in disease severity.
AU  - de,Morais Batista F
AU  - Puga,MAM
AU  - da,Silva PV
AU  - Oliveira,R
AU  - Dos,Santos PCP
AU  - da,Silva BO
AU  - Tatara,MB
AU  - Tsuha,DH
AU  - Dos,Santos Pires MA
AU  - Gonçalves,CCM
AU  - Pessoa,E Silva R
AU  - Ferreira,NT
AU  - de,Barros Albuquerque AP
AU  - da,Silva Duarte G
AU  - Consolaro,MEL
AU  - Negrão,FJ
AU  - Ferrari,IC
AU  - de,Goes Cavalcanti LP
AU  - Trinta,KS
AU  - Ribeiro,GS
AU  - de,Melo Rêgo MJB
AU  - Boyton,RJ
AU  - Siqueira,AM
AU  - Altmann,DM
AU  - Croda,J
DO  - 10.1038/s41598-022-20062-5
PY  - 2022///
SN  - 2045-2322
TI  - Serum biomarkers associated with SARS-CoV-2 severity
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-022-20062-5
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36163447
UR  - http://hdl.handle.net/10044/1/100115
VL  - 12
ER  -
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