Imperial College London
Alternate

Professor Daqing Ma, MD, PhD

Faculty of Medicine, Department of Surgery & Cancer

Professor of Anaesthesia
 
 
 
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Contact

 

+44 (0)20 3315 8495d.ma Website

 
 
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Assistant

 

Miss Steffi Klier +44 (0)20 3315 8816

 
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Location

 

G3.44Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2012:10.1371/journal.pone.0037020,
author = {Yang, T and Zhuang, L and Fidalgo, AMR and Petrides, E and Terrando, N and Wu, X and Sanders, RD and Robertson, NJ and Johnson, MR and Maze, M and Ma, D},
doi = {10.1371/journal.pone.0037020},
journal = {PLoS ONE},
title = {Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia},
url = {http://dx.doi.org/10.1371/journal.pone.0037020},
volume = {7},
year = {2012}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women usesome form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when usedas analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agentswith presumptive analgesic activity and known preconditioning-neuroprotective properties (sevoflurane or xenon), inreducing hypoxia-induced brain damage in a model of intrauterine perinatal asphyxia. The analgesic and neuroprotectiveeffects at subanesthetic levels of sevoflurane (0.35%) or xenon (35%) were tested in a rat model of intrauterine perinatalasphyxia. Analgesic effects were measured by assessing maternal behavior and spinal cord dorsal horn neuronal activationusing c-Fos. In separate experiments, intrauterine fetal asphyxia was induced four hours after gas exposure; on post-insultday 3 apoptotic cell death was measured by caspase-3 immunostaining in hippocampal neurons and correlated with thenumber of viable neurons on postnatal day (PND) 7. A separate cohort of pups was nurtured by a surrogate mother for 50days when cognitive testing with Morris water maze was performed. Both anesthetic agents provided analgesia as reflectedby a reduction in the number of stretching movements and decreased c-Fos expression in the dorsal horn of the spinal cord.Both agents also reduced the number of caspase-3 positive (apoptotic) neurons and increased cell viability in thehippocampus at PND7. These acute histological changes were mirrored by improved cognitive function measured remotelyafter birth on PND 50 compared to control group. Subanesthetic doses of sevoflurane or xenon provided both analgesiaand neuroprotection in this model of intrauterine perinatal asphyxia. These data suggest that anesthetic agents withneuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the fu
AU  - Yang,T
AU  - Zhuang,L
AU  - Fidalgo,AMR
AU  - Petrides,E
AU  - Terrando,N
AU  - Wu,X
AU  - Sanders,RD
AU  - Robertson,NJ
AU  - Johnson,MR
AU  - Maze,M
AU  - Ma,D
DO  - 10.1371/journal.pone.0037020
PY  - 2012///
SN  - 1932-6203
TI  - Xenon and sevoflurane provide analgesia during labor and fetal brain protection in a perinatal rat model of hypoxia-ischemia
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0037020
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305341200034&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71926
VL  - 7
ER  -
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