Imperial College London
Alternate

DrDavidMann

Faculty of Natural Sciences, Department of Life Sciences

Reader in Cell Cycle Control
 
 
 
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Contact

 

+44 (0)20 7594 5302d.mann

 
 
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Location

 

605Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cohen:1990:10.1016/0014-5793(90)81285-v,
author = {Cohen, PT and Brewis, ND and Hughes, V and Mann, DJ},
doi = {10.1016/0014-5793(90)81285-v},
journal = {FEBS Lett},
pages = {355--359},
title = {Protein serine/threonine phosphatases; an expanding family.},
url = {http://dx.doi.org/10.1016/0014-5793(90)81285-v},
volume = {268},
year = {1990}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Five protein serine/threonine phosphatases (PP) have been identified by cloning cDNA from mammalian and Drosophila libraries. These novel enzymes, which have not yet been detected by the techniques of protein chemistry and enzymology, are termed PPV, PP2Bw, PPX, PPY and PPZ. The complete amino acid sequences of PPX, PPY and PPZ and an almost complete sequence of PPV are presented. In the catalytic domain PPV and PPX are more similar to PP2A (57-69% identity) than PP1 (45-49% identity), while PPY and PPZ are more similar to PP1 (66-68% identity) than PP2A (44% identity). The cDNA for PP2Bw encodes a novel Ca2+/calmodulin-dependent protein phosphatase only 62% identical to PP2B in the catalytic domain. Approaches for determining the cellular functions of these protein phosphatases are discussed.
AU  - Cohen,PT
AU  - Brewis,ND
AU  - Hughes,V
AU  - Mann,DJ
DO  - 10.1016/0014-5793(90)81285-v
EP  - 359
PY  - 1990///
SN  - 0014-5793
SP  - 355
TI  - Protein serine/threonine phosphatases; an expanding family.
T2  - FEBS Lett
UR  - http://dx.doi.org/10.1016/0014-5793(90)81285-v
UR  - https://www.ncbi.nlm.nih.gov/pubmed/2166691
VL  - 268
ER  -
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