Imperial College London
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ProfessorDarrylOverby

Faculty of Engineering, Department of Bioengineering

Professor of Mechanobiology
 
 
 
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Contact

 

+44 (0)20 7594 6376d.overby

 
 
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Location

 

3.07Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Martella:2016:10.1210/en.2015-1384,
author = {Martella, A and Silvestri, C and Maradonna, F and Gioacchini, G and Allara, M and Radaelli, G and Overby, DR and Di, Marzo V and Carnevali, O},
doi = {10.1210/en.2015-1384},
journal = {Endocrinology},
pages = {1751--1763},
title = {Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop},
url = {http://dx.doi.org/10.1210/en.2015-1384},
volume = {157},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The xenoestrogen bisphenol A (BPA) is a widespread plasticizer detectable within several ecosystems. BPA is considered a metabolic disruptor, affecting different organs; however, little is known about its mechanism of action in the liver, in which it triggers triglyceride accumulation. Adult zebrafish (Danio rerio) exposed to BPA developed hepatosteatosis, which was associated with an increase in the liver levels of the obesogenic endocannabinoids 2-arachidonoylglycerol and anandamide and a concomitant decrease in palmitoylethanolamide. These changes were associated with variations in the expression of key endocannabinoid catabolic and metabolic enzymes and an increase in the expression of the endocannabinoid receptor cnr1. Acute and chronic in vitro treatments with nano- and micromolar BPA doses showed increased anandamide levels in line with decreased activity of fatty acid amide hydrolase, the main anandamide hydrolytic enzyme, and induced triglyceride accumulation in HHL-5 cells in a CB1-dependent manner. We conclude that BPA is able to produce hepatosteatosis in zebrafish and human hepatocytes by up-regulating the endocannabinoid system.
AU  - Martella,A
AU  - Silvestri,C
AU  - Maradonna,F
AU  - Gioacchini,G
AU  - Allara,M
AU  - Radaelli,G
AU  - Overby,DR
AU  - Di,Marzo V
AU  - Carnevali,O
DO  - 10.1210/en.2015-1384
EP  - 1763
PY  - 2016///
SN  - 0013-7227
SP  - 1751
TI  - Bisphenol A induces fatty liver by an endocannabinoid-mediated positive feedback loop
T2  - Endocrinology
UR  - http://dx.doi.org/10.1210/en.2015-1384
UR  - http://hdl.handle.net/10044/1/45802
VL  - 157
ER  -
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