Imperial College London
Alternate

ProfessorDavidBrooks

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

david.brooks

 
 
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Assistant

 

Ms Hyacinth Henry +44 (0)20 3313 3172

 
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Location

 

U106Block B Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pasquini:2024:10.1016/j.jns.2024.122985,
author = {Pasquini, J and Firbank, MJ and Best, L and Foster, V and Galley, D and Silani, V and Ceravolo, R and Petrides, G and Brooks, DJ and Anderson, KN and Pavese, N},
doi = {10.1016/j.jns.2024.122985},
journal = {J Neurol Sci},
title = {Hypothalamic involvement in multiple system atrophy: A structural MRI study.},
url = {http://dx.doi.org/10.1016/j.jns.2024.122985},
volume = {460},
year = {2024}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To investigate hypothalamic atrophy and its clinical correlates in multiple system atrophy (MSA) in-vivo. BACKGROUND: MSA is characterized by autonomic dysfunction and parkinsonian/cerebellar manifestations. The hypothalamus regulates autonomic and homeostatic functions and is also involved in memory and learning processes. METHODS: 11 MSA, 18 Parkinson's Disease (PD) and 18 Healthy Controls (HC) were included in this study. A validated and automated hypothalamic segmentation tool was applied to 3D-T1-weighted images acquired on a 3T MRI scanner. MSA hypothalamic volumes were compared to those of PD and HC. Furthermore, the association between hypothalamic volumes and scores of autonomic, depressive, sleep and cognitive manifestations were investigated. RESULTS: Posterior hypothalamus volume was reduced in MSA compared to controls (t = 2.105, p = 0.041) and PD (t = 2.055, p = 0.046). Total hypothalamus showed a trend towards a reduction in MSA vs controls (t = 1.676, p = 0.101). Reduced posterior hypothalamus volume correlated with worse MoCA scores in the parkinsonian (MSA + PD) group and in each group separately, but not with autonomic, sleep, or depression scores. CONCLUSIONS: In-vivo structural hypothalamic involvement may be present in MSA. Reduced posterior hypothalamus volume, which includes the mammillary bodies and lateral hypothalamus, is associated with worse cognitive functioning. Larger studies on hypothalamic involvement in MSA and its clinical correlates are needed.
AU  - Pasquini,J
AU  - Firbank,MJ
AU  - Best,L
AU  - Foster,V
AU  - Galley,D
AU  - Silani,V
AU  - Ceravolo,R
AU  - Petrides,G
AU  - Brooks,DJ
AU  - Anderson,KN
AU  - Pavese,N
DO  - 10.1016/j.jns.2024.122985
PY  - 2024///
TI  - Hypothalamic involvement in multiple system atrophy: A structural MRI study.
T2  - J Neurol Sci
UR  - http://dx.doi.org/10.1016/j.jns.2024.122985
UR  - https://www.ncbi.nlm.nih.gov/pubmed/38581741
VL  - 460
ER  -
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