Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
//

Contact

 

e.riboli Website CV

 
 
//

Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
//

Location

 

152Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@inproceedings{Clasen:2021:ije/dyab168.135,
author = {Clasen, J and Heath, AK and Van, Puyvelde H and Huybrechts, I and Johansson, M and Ferrari, P and Park, JY and Brennan, P and Riboli, E and Muller, DC},
doi = {ije/dyab168.135},
pages = {1--1},
publisher = {Oxford University Press},
title = {Vitamin B6 intake, its active form pyridoxal 5'phosphate, and markers of B6 activity and catabolism},
url = {http://dx.doi.org/10.1093/ije/dyab168.135},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - BackgroundSeveral biological pathways implicated in cancer risk rely on vitamin B6, which can be measured in its active form pyridoxal 5’-phosphate (PLP). Functional markers of B6 enzymatic activity have been proposed, including the homocysteine:cysteine ratio (Hcy:Cys, a marker of transsulfuration), 3-hydroxykynurenine ratio (HKr, a marker of tryptophan catabolism), and the 4-pyridoxic acid ratio (PAr, a marker of B6 catabolism). We investigated the extent to which these markers are associated with B6 intake.MethodsData from 4,750 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. We estimated the expected percentage change in each of the markers (PLP, Hcy:Cys, HKr, and PAr) for a doubling in B6 intake using log-linear Bayesian hierarchical regression models with log-transformed intake and biomarker data.ResultsThe percent change (posterior mean [95% Credible Interval (CrI)]) for a doubling of B6 intake was 61.0 [51.2, 71.8] for PLP, -12.7 [-15.2, -9.9] for Hcy:Cys, -12.9 [-15.7, -9.9] for HKr, and 1.3 [-3.5, 6.2] for PAr.ConclusionsB6 intake is most strongly associated with PLP, but is also associated with functional markers of transsulfuration and tryptophan catabolism, in the direction of increased activity in these pathways. There is no evidence of a linear association between vitamin B6 intake and catabolism.Key messagesOur results show differing sensitivity of PLP, markers of tryptophan catabolism and transsulfuration, and vitamin B6 catabolism to B6 intake.
AU  - Clasen,J
AU  - Heath,AK
AU  - Van,Puyvelde H
AU  - Huybrechts,I
AU  - Johansson,M
AU  - Ferrari,P
AU  - Park,JY
AU  - Brennan,P
AU  - Riboli,E
AU  - Muller,DC
DO  - ije/dyab168.135
EP  - 1
PB  - Oxford University Press
PY  - 2021///
SN  - 0300-5771
SP  - 1
TI  - Vitamin B6 intake, its active form pyridoxal 5'phosphate, and markers of B6 activity and catabolism
UR  - http://dx.doi.org/10.1093/ije/dyab168.135
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000695815900129&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://academic.oup.com/ije/article/50/Supplement_1/dyab168.135/6361424
UR  - http://hdl.handle.net/10044/1/93891
ER  -
Download