Imperial College London
Alternate

ProfessorElioRiboli

Faculty of Medicine, School of Public Health

Chair in Cancer Epidemiology and Prevention
 
 
 
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Contact

 

e.riboli Website CV

 
 
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Assistant

 

Ms Julieta Dourado +44 (0)20 7594 3426

 
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Location

 

152Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zheng:2022:10.14283/jpad.2022.8,
author = {Zheng, B and Su, B and Udeh-Momoh, C and Price, G and Tzoulaki, I and Vamos, EP and Majeed, A and Riboli, E and Ahmadi-Abhari, S and Middleton, LT},
doi = {10.14283/jpad.2022.8},
journal = {JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE},
pages = {86--91},
title = {Associations of cardiovascular and non-cardiovascular comorbidities with dementia risk in patients with diabetes: results from a large UK cohort study},
url = {http://dx.doi.org/10.14283/jpad.2022.8},
volume = {9},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundType 2 diabetes (T2D) is an established risk factor for dementia. However, it remains unclear whether the presence of comorbidities could further increase dementia risk in diabetes patients.ObjectivesTo examine the associations between cardiovascular and non-cardiovascular comorbidities and dementia risk in T2D patients.DesignPopulation-based cohort study.SettingThe UK Clinical Practice Research Datalink (CPRD).Participants489,205 T2D patients aged over 50 years in the UK CPRD.MeasurementsMajor cardiovascular and non-cardiovascular comorbidities were extracted as time-varying exposure variables. The outcome event was dementia incidence based on dementia diagnosis or dementia-specific drug prescription.ResultsDuring a median of six years follow-up, 33,773 (6.9%) incident dementia cases were observed. Time-varying Cox regressions showed T2D patients with stroke, peripheral vascular disease, atrial fibrillation, heart failure or hypertension were at higher risk of dementia compared to those without such comorbidities (HR [95% CI] = 1.64 [1.59–1.68], 1.37 [1.34–1.41], 1.26 [1.22–1.30], 1.15 [1.11–1.20] or 1.10 [1.03–1.18], respectively). Presence of chronic obstructive pulmonary disease or chronic kidney disease was also associated with increased dementia risk (HR [95% CI] = 1.05 [1.01–1.10] or 1.11 [1.07–1.14]).ConclusionsA range of cardiovascular and non-cardiovascular comorbidities were associated with further increases of dementia risk in T2D patients. Prevention and effective management of these comorbidities may play a significant role in maintaining cognitive health in T2D patients.
AU  - Zheng,B
AU  - Su,B
AU  - Udeh-Momoh,C
AU  - Price,G
AU  - Tzoulaki,I
AU  - Vamos,EP
AU  - Majeed,A
AU  - Riboli,E
AU  - Ahmadi-Abhari,S
AU  - Middleton,LT
DO  - 10.14283/jpad.2022.8
EP  - 91
PY  - 2022///
SN  - 2274-5807
SP  - 86
TI  - Associations of cardiovascular and non-cardiovascular comorbidities with dementia risk in patients with diabetes: results from a large UK cohort study
T2  - JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
UR  - http://dx.doi.org/10.14283/jpad.2022.8
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000745583500002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.14283/jpad.2022.8
UR  - http://hdl.handle.net/10044/1/94243
VL  - 9
ER  -
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