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@article{Yammine:2023:10.1186/s12885-023-10611-0,
author = {Yammine, SG and Huybrechts, I and Biessy, C and Dossus, L and Panico, S and Sánchez, MJ and Benetou, V and Turzanski-Fortner, R and Katzke, V and Idahl, A and Skeie, G and Olsen, KS and Tjønneland, A and Halkjaer, J and Colorado-Yohar, S and Heath, AK and Sonestedt, E and Sartor, H and Schulze, MB and Palli, D and Crous-Bou, M and Dorronsoro, A and Overvad, K and Gurrea, AB and Severi, G and Vermeulen, RCH and Sandanger, TM and Travis, RC and Key, T and Amiano, P and Van, Guelpen B and Johansson, M and Sund, M and Tumino, R and Wareham, N and Sacerdote, C and Krogh, V and Brennan, P and Riboli, E and Weiderpass, E and Gunter, MJ and Chajès, V},
doi = {10.1186/s12885-023-10611-0},
journal = {BMC Cancer},
pages = {1--12},
title = {Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.},
url = {http://dx.doi.org/10.1186/s12885-023-10611-0},
volume = {23},
year = {2023}
}

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TY  - JOUR
AB  - BACKGROUND: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. RESULTS: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5-Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. CONCLUSION: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.
AU  - Yammine,SG
AU  - Huybrechts,I
AU  - Biessy,C
AU  - Dossus,L
AU  - Panico,S
AU  - Sánchez,MJ
AU  - Benetou,V
AU  - Turzanski-Fortner,R
AU  - Katzke,V
AU  - Idahl,A
AU  - Skeie,G
AU  - Olsen,KS
AU  - Tjønneland,A
AU  - Halkjaer,J
AU  - Colorado-Yohar,S
AU  - Heath,AK
AU  - Sonestedt,E
AU  - Sartor,H
AU  - Schulze,MB
AU  - Palli,D
AU  - Crous-Bou,M
AU  - Dorronsoro,A
AU  - Overvad,K
AU  - Gurrea,AB
AU  - Severi,G
AU  - Vermeulen,RCH
AU  - Sandanger,TM
AU  - Travis,RC
AU  - Key,T
AU  - Amiano,P
AU  - Van,Guelpen B
AU  - Johansson,M
AU  - Sund,M
AU  - Tumino,R
AU  - Wareham,N
AU  - Sacerdote,C
AU  - Krogh,V
AU  - Brennan,P
AU  - Riboli,E
AU  - Weiderpass,E
AU  - Gunter,MJ
AU  - Chajès,V
DO  - 10.1186/s12885-023-10611-0
EP  - 12
PY  - 2023///
SN  - 1471-2407
SP  - 1
TI  - Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition.
T2  - BMC Cancer
UR  - http://dx.doi.org/10.1186/s12885-023-10611-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36797668
UR  - https://bmccancer.biomedcentral.com/articles/10.1186/s12885-023-10611-0
UR  - http://hdl.handle.net/10044/1/102952
VL  - 23
ER  -

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