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@article{Kröger:2018:10.2337/db17-1268,
author = {Kröger, J and Meidtner, K and Stefan, N and Guevara, M and Kerrison, ND and Ardanaz, E and Aune, D and Boeing, H and Dorronsoro, M and Dow, C and Fagherazzi, G and Franks, PW and Freisling, H and Gunter, MJ and Huerta, JM and Kaaks, R and Key, TJ and Khaw, KT and Krogh, V and Kühn, T and Mancini, FR and Mattiello, A and Nilsson, PM and Olsen, A and Overvad, K and Palli, D and Quirós, JR and Rolandsson, O and Sacerdote, C and Sala, N and Salamanca-Fernández, E and Sluijs, I and Spijkerman, AM and Tjonneland, A and Tsilidis, KK and Tumino, R and van, der Schouw YT and Forouhi, NG and Sharp, SJ and Langenberg, C and Riboli, E and Schulze, MB and Wareham, NJ},
doi = {10.2337/db17-1268},
journal = {Diabetes},
pages = {1200--1205},
title = {Circulating Fetuin-A and risk of Type 2 Diabetes: a Mendelian randomization analysis},
url = {http://dx.doi.org/10.2337/db17-1268},
volume = {67},
year = {2018}
}

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TY  - JOUR
AB  - Fetuin-A, a hepatic-origin protein, is strongly positively associated with risk of type 2 diabetes in human observational studies, but it is unknown whether this association is causal. We aimed to study the potential causal relation of circulating fetuin-A to risk of type 2 diabetes in a Mendelian Randomization study with SNPs located in the fetuin-A-encodingAHSGgene. We used data from eight European countries of the prospective EPIC-InterAct case-cohort study including 10,020 incident cases. Plasma fetuin-A concentration was measured in a subset of 965 subcohort participants and 654 cases. A genetic score of theAHSGSNPs was strongly associated with fetuin-A (28% explained variation). Using the genetic score as instrumental variable of fetuin-A, we observed no significant association of a 50 µg/ml higher fetuin-A concentration with diabetes risk (HR 1.02 [95%-CI 0.97, 1.07]). Combining our results with those from the Diabetes Genetics Replication And Meta-analysis (DIAGRAM) consortium (12,171 cases) also did not suggest a clear significant relation of fetuin-A with diabetes risk. In conclusion, although there is mechanistical evidence for an effect of fetuin-A on insulin sensitivity and secretion, this study doesn't support a strong, relevant relationship between circulating fetuin-A and diabetes risk in the general population.
AU  - Kröger,J
AU  - Meidtner,K
AU  - Stefan,N
AU  - Guevara,M
AU  - Kerrison,ND
AU  - Ardanaz,E
AU  - Aune,D
AU  - Boeing,H
AU  - Dorronsoro,M
AU  - Dow,C
AU  - Fagherazzi,G
AU  - Franks,PW
AU  - Freisling,H
AU  - Gunter,MJ
AU  - Huerta,JM
AU  - Kaaks,R
AU  - Key,TJ
AU  - Khaw,KT
AU  - Krogh,V
AU  - Kühn,T
AU  - Mancini,FR
AU  - Mattiello,A
AU  - Nilsson,PM
AU  - Olsen,A
AU  - Overvad,K
AU  - Palli,D
AU  - Quirós,JR
AU  - Rolandsson,O
AU  - Sacerdote,C
AU  - Sala,N
AU  - Salamanca-Fernández,E
AU  - Sluijs,I
AU  - Spijkerman,AM
AU  - Tjonneland,A
AU  - Tsilidis,KK
AU  - Tumino,R
AU  - van,der Schouw YT
AU  - Forouhi,NG
AU  - Sharp,SJ
AU  - Langenberg,C
AU  - Riboli,E
AU  - Schulze,MB
AU  - Wareham,NJ
DO  - 10.2337/db17-1268
EP  - 1205
PY  - 2018///
SN  - 0012-1797
SP  - 1200
TI  - Circulating Fetuin-A and risk of Type 2 Diabetes: a Mendelian randomization analysis
T2  - Diabetes
UR  - http://dx.doi.org/10.2337/db17-1268
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29523632
UR  - http://hdl.handle.net/10044/1/57866
VL  - 67
ER  -

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