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@article{Baker:2004:10.3201/eid1009.040046,
author = {Baker, LV and Brown, T and Maiden, MCJM and Drobniewski, FA},
doi = {10.3201/eid1009.040046},
journal = {Emerging Infectious Diseases},
pages = {1568--1577},
title = {Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis},
url = {http://dx.doi.org/10.3201/eid1009.040046},
volume = {10},
year = {2004}
}

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TY  - JOUR
AB  - Much remains unknown of the phylogeny and evolution of Mycobacterium tuberculosis, an organism that kills 2 million people annually. Using a population-based approach that analyzes multiple loci around the chromosome, we demonstrate that neutral genetic variation in genes associated with antimicrobial drug resistance has sufficient variation to construct a robust phylogenetic tree for M. tuberculosis. The data describe a clonal population with a minimum of four distinct M. tuberculosis lineages, closely related to M. bovis. The lineages are strongly geographically associated. Nucleotide substitutions proven to cause drug resistance are distributed throughout the tree, whereas nonsynonymous base substitutions unrelated to drug resistance have a restricted distribution. The phylogenetic structure is concordant with all the previously described genotypic and phenotypic groupings of M. tuberculosis strains and provides a unifying framework for both epidemiologic and evolutionary analysis of M. tuberculosis populations.
AU  - Baker,LV
AU  - Brown,T
AU  - Maiden,MCJM
AU  - Drobniewski,FA
DO  - 10.3201/eid1009.040046
EP  - 1577
PY  - 2004///
SN  - 1080-6059
SP  - 1568
TI  - Silent nucleotide polymorphisms and a phylogeny for Mycobacterium tuberculosis
T2  - Emerging Infectious Diseases
UR  - http://dx.doi.org/10.3201/eid1009.040046
UR  - http://hdl.handle.net/10044/1/23734
VL  - 10
ER  -

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Professor Francis Drobniewski

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