Imperial College London
Alternate

DrGeraldLarrouy-Maumus

Faculty of Natural Sciences, Department of Life Sciences

Reader in Molecular Microbiology
 
 
 
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Contact

 

+44 (0)20 7594 7463g.larrouy-maumus

 
 
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Location

 

3.42Flowers buildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Liu:2023:10.1038/s41598-023-37641-9,
author = {Liu, Y and Kaffah, N and Pandor, S and Sartain, MJ and Larrouy-Maumus, G},
doi = {10.1038/s41598-023-37641-9},
journal = {Scientific Reports},
pages = {1--8},
title = {Ion mobility mass spectrometry for the study of mycobacterial mycolic acids},
url = {http://dx.doi.org/10.1038/s41598-023-37641-9},
volume = {13},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Lipids are highly structurally diverse molecules involved in a wide variety of biological processes. The involvement of lipids is even more pronounced in mycobacteria, including the human pathogen Mycobacterium tuberculosis, which produces a highly complex and diverse set of lipids in the cell envelope. These lipids include mycolic acids, which are among the longest fatty acids in nature and can contain up to 90 carbon atoms. Mycolic acids are ubiquitously found in mycobacteria and are alpha branched and beta hydroxylated lipids. Discrete modifications, such as alpha, alpha’, epoxy, methoxy, keto, and carboxy, characterize mycolic acids at the species level. Here, we used high precision ion mobility-mass spectrometry to build a database including 206 mass-resolved collision cross sections (CCSs) of mycolic acids originating from the strict human pathogen M. tuberculosis, the opportunistic strains M. abscessus, M. marinum and M. avium, and the nonpathogenic strain M. smegmatis. Primary differences between the mycolic acid profiles could be observed between mycobacterial species. Acyl tail length and modifications were the primary structural descriptors determining CCS magnitude. As a resource for researchers, this work provides a detailed catalogue of the mass-resolved collision cross sections for mycolic acids along with a workflow to generate and analyse the dataset generated.
AU  - Liu,Y
AU  - Kaffah,N
AU  - Pandor,S
AU  - Sartain,MJ
AU  - Larrouy-Maumus,G
DO  - 10.1038/s41598-023-37641-9
EP  - 8
PY  - 2023///
SN  - 2045-2322
SP  - 1
TI  - Ion mobility mass spectrometry for the study of mycobacterial mycolic acids
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-023-37641-9
UR  - https://www.nature.com/articles/s41598-023-37641-9
UR  - http://hdl.handle.net/10044/1/105123
VL  - 13
ER  -
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