Imperial College London
Portrait Picture

Professor Hani Gabra

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor of Medical Oncology
 
 
 
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Contact

 

h.gabra Website

 
 
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Assistant

 

Ms Sophie Lions +44 (0)20 7594 2792

 
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Location

 

Garry Weston CentreCancer CentreHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chiu:2018:10.1016/j.celrep.2018.03.064,
author = {Chiu, H-S and Somvanshi, S and Patel, E and Chen, T-W and Singh, VP and Zorman, B and Patil, SL and Pan, Y and Chatterjee, SS and Sood, AK and Gunaratne, PH and Sumazin, P},
doi = {10.1016/j.celrep.2018.03.064},
journal = {Cell Reports},
pages = {297--312.e12},
title = {Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes ineach tumor context},
url = {http://dx.doi.org/10.1016/j.celrep.2018.03.064},
volume = {23},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts. To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells. Our analysis indicates that, although most lncRNAs are dysregulated in a tumor-specific manner, some, including OIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergistically dysregulate cancer pathways in multiple tumor contexts.
AU  - Chiu,H-S
AU  - Somvanshi,S
AU  - Patel,E
AU  - Chen,T-W
AU  - Singh,VP
AU  - Zorman,B
AU  - Patil,SL
AU  - Pan,Y
AU  - Chatterjee,SS
AU  - Sood,AK
AU  - Gunaratne,PH
AU  - Sumazin,P
DO  - 10.1016/j.celrep.2018.03.064
EP  - 312
PY  - 2018///
SN  - 2211-1247
SP  - 297
TI  - Pan-cancer analysis of lncRNA regulation supports their targeting of cancer genes ineach tumor context
T2  - Cell Reports
UR  - http://dx.doi.org/10.1016/j.celrep.2018.03.064
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000429092900025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/71247
VL  - 23
ER  -
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