Imperial College London
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Professor Hani Gabra

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor of Medical Oncology
 
 
 
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Contact

 

h.gabra Website

 
 
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Assistant

 

Ms Sophie Lions +44 (0)20 7594 2792

 
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Location

 

Garry Weston CentreCancer CentreHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Matsuo:2017:10.1002/jso.24801,
author = {Matsuo, K and Wong, K-K and Fotopoulou, C and Blake, EA and Robertson, SE and Pejovic, T and Frimer, M and Pardeshi, V and Hu, W and Choi, J-S and Sun, CC and Richmond, AM and Marcus, JZ and Hilliard, MAM and Mostofizadeh, S and Mhawech-Fauceglia, P and Abdulfatah, E and Post, MD and Shahzad, MMK and Karabakhtsian, RG and Ali-Fehmi, R and Gabra, H and Roman, LD and Sood, AK and Gershenson, DM},
doi = {10.1002/jso.24801},
journal = {Journal of Surgical Oncology},
pages = {236--244},
title = {Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma},
url = {http://dx.doi.org/10.1002/jso.24801},
volume = {117},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVES: To examine association of lympho-vascular space invasion (LVSI) with clinico-pathological factors and to evaluate survival of women with low-grade serous ovarian carcinoma containing areas of LVSI. METHODS: This is a multicenter retrospective study examining consecutive cases of surgically treated stage I-IV low-grade serous ovarian carcinoma (n = 178). Archived histopathology slides for the ovarian tumors were reviewed, and LVSI was scored as present or absent. LVSI status was correlated to clinico-pathological findings and survival outcome. RESULTS: LVSI was seen in 79 cases (44.4%, 95% confidence interval [CI] 37.1-51.7). LVSI was associated with increased risk of omental metastasis (87.0% vs 64.9%, odds ratio [OR] 3.62, P = 0.001), high pelvic lymph node ratio (median 12.9% vs 0%, P = 0.012), and malignant ascites (49.3% vs 32.6%, OR 2.01, P = 0.035). On multivariable analysis, controlling for age, stage, and cytoreductive status, presence of LVSI in the ovarian tumor remained an independent predictor for decreased progression-free survival (5-year rates 21.0% vs 35.7%, adjusted-hazard ratio 1.57, 95%CI 1.06-2.34, P = 0.026). LVSI was significantly associated with increased risk of recurrence in lymph nodes (OR 2.62, 95%CI 1.08-6.35, P = 0.047). CONCLUSION: LVSI in the ovarian tumor is associated with adverse clinico-pathological characteristics and decreased progression-free survival in women with low-grade serous ovarian carcinoma.
AU  - Matsuo,K
AU  - Wong,K-K
AU  - Fotopoulou,C
AU  - Blake,EA
AU  - Robertson,SE
AU  - Pejovic,T
AU  - Frimer,M
AU  - Pardeshi,V
AU  - Hu,W
AU  - Choi,J-S
AU  - Sun,CC
AU  - Richmond,AM
AU  - Marcus,JZ
AU  - Hilliard,MAM
AU  - Mostofizadeh,S
AU  - Mhawech-Fauceglia,P
AU  - Abdulfatah,E
AU  - Post,MD
AU  - Shahzad,MMK
AU  - Karabakhtsian,RG
AU  - Ali-Fehmi,R
AU  - Gabra,H
AU  - Roman,LD
AU  - Sood,AK
AU  - Gershenson,DM
DO  - 10.1002/jso.24801
EP  - 244
PY  - 2017///
SN  - 1096-9098
SP  - 236
TI  - Impact of lympho-vascular space invasion on tumor characteristics and survival outcome of women with low-grade serous ovarian carcinoma
T2  - Journal of Surgical Oncology
UR  - http://dx.doi.org/10.1002/jso.24801
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28787528
UR  - http://hdl.handle.net/10044/1/50302
VL  - 117
ER  -
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