Imperial College London
Alternate

ProfessorJesusGil

Faculty of Medicine, Institute of Clinical Sciences

Professor of Cell Proliferation
 
 
 
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Contact

 

+44 (0)20 3313 8263jesus.gil

 
 
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Location

 

ICTEM room 230ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Banito:2013:10.1007/978-94-007-5958-9_16,
author = {Banito, A and Gil, J},
booktitle = {Tumor Dormancy, Quiescence, and Senescence: Aging, Cancer, and Noncancer Pathologies},
doi = {10.1007/978-94-007-5958-9_16},
pages = {195--205},
title = {Enhancing reprogramming to pluripotency by controlling senescence},
url = {http://dx.doi.org/10.1007/978-94-007-5958-9_16},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - Induced pluripotent stem (iPS) cells can be obtained through the reprogramming of somatic cells by ectopic expression of defined factors. These cells hold immense promise for autologous cell therapy and disease modeling however, understanding the mechanistic of direct reprogramming is also shedding light into important biological processes. Several studies have shown how key tumor suppressors may interfere with reprogramming efficiency by activating cell-intrinsic programmes such as senescence and apoptosis. The repercussions of these findings are profound and reveal a link between tumor suppression and loss of differentiation. Here we analyze the latest findings in the field and discuss their relevance for iPS technology and tumor development.
AU  - Banito,A
AU  - Gil,J
DO  - 10.1007/978-94-007-5958-9_16
EP  - 205
PY  - 2013///
SN  - 9789400759572
SP  - 195
TI  - Enhancing reprogramming to pluripotency by controlling senescence
T1  - Tumor Dormancy, Quiescence, and Senescence: Aging, Cancer, and Noncancer Pathologies
UR  - http://dx.doi.org/10.1007/978-94-007-5958-9_16
ER  -
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