Imperial College London
Alternate

Joanne P. Webster

Faculty of Medicine, School of Public Health

Visiting Professor
 
 
 
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Contact

 

joanne.webster Website

 
 
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Location

 

Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nkemngo:2023:10.1371/journal.pone.0288560,
author = {Nkemngo, FN and W, G Raissa L and Nebangwa, DN and Nkeng, AM and Kengne, A and Mugenzi, LMJ and Fotso-Toguem, YG and Wondji, MJ and Shey, RA and Nguiffo-Nguete, D and Fru-Cho, J and Ndo, C and Njiokou, F and Webster, JP and Wanji, S and Wondji, CS},
doi = {10.1371/journal.pone.0288560},
journal = {PLoS One},
title = {Epidemiology of malaria, schistosomiasis, and geohelminthiasis amongst children 3-15 years of age during the dry season in Northern Cameroon},
url = {http://dx.doi.org/10.1371/journal.pone.0288560},
volume = {18},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: The double burden of malaria and helminthiasis in children poses an obvious public health challenge, particularly in terms of anemia morbidity. While both diseases frequently geographically overlap, most studies focus on mono-infection and general prevalence surveys without molecular analysis. The current study investigated the epidemiological determinants of malaria, schistosomiasis, and geohelminthiasis transmission among children in the North Region of Cameroon. METHODOLOGY: School and pre-school children aged 3-15 year-of-age were enrolled from three communities in March 2021 using a community cross-sectional design. Capillary-blood samples were obtained, and each was examined for malaria parasites using rapid-diagnostic-test (RDT), microscopy, and PCR while hemoglobin level was measured using a hemoglobinometer. Stool samples were analyzed for Schistosoma mansoni, S. guineensis, and soil-transmitted-helminthiasis (STH) infections using the Kato Katz method, and urine samples were assessed for the presence of S. haematobium eggs (including hybrids) using the standard urine filtration technique. RESULT: A malaria prevalence of 56% (277/495) was recorded by PCR as opposed to 31.5% (156/495) by microscopy and 37.8% (186/495) by RDT. Similarly, schistosomiasis was observed at prevalence levels of up to 13.3% (66/495) overall [S. haematobium (8.7%); S. mansoni (3.8%); mixed Sh/Sm (0.6%); mixed Sh/Sm/Sg (0.2%). Both infections were higher in males and the 3-9 year-of-age groups. A high frequency of PCR reported P. falciparum mono-infection of 81.9% (227/277) and mixed P. falciparum/P. malariae infection of 17.3% (48/277) was observed. Malaria-helminths co-infections were observed at 13.1% (65/495) with marked variation between P. falciparum/S. haematobium (50.8%, 33/65); P. falciparum/S. mansoni (16.9%, 11/65) and P. falciparum/Ascaris (9.2%, 6/65) (χ2 = 17.5, p = 0.00003). Anemia prevalence was 32.9% (163/495), categorically associated with P. falcipa
AU  - Nkemngo,FN
AU  - W,G Raissa L
AU  - Nebangwa,DN
AU  - Nkeng,AM
AU  - Kengne,A
AU  - Mugenzi,LMJ
AU  - Fotso-Toguem,YG
AU  - Wondji,MJ
AU  - Shey,RA
AU  - Nguiffo-Nguete,D
AU  - Fru-Cho,J
AU  - Ndo,C
AU  - Njiokou,F
AU  - Webster,JP
AU  - Wanji,S
AU  - Wondji,CS
DO  - 10.1371/journal.pone.0288560
PY  - 2023///
SN  - 1932-6203
TI  - Epidemiology of malaria, schistosomiasis, and geohelminthiasis amongst children 3-15 years of age during the dry season in Northern Cameroon
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0288560
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37523402
UR  - https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0288560
UR  - http://hdl.handle.net/10044/1/108323
VL  - 18
ER  -
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