Imperial College London

Professor Joshua B. Edel

Faculty of Natural SciencesDepartment of Chemistry

Professor of Biosensing & Analytical Sciences
 
 
 
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Contact

 

+44 (0)20 7594 0754joshua.edel Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

442AChemistrySouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ren:2017:10.1038/s41467-017-00549-w,
author = {Ren, R and Zhang, Y and Paulose, Nadappuram B and Akpinar, B and Klenerman, D and Ivanov, AP and Edel, JB and Korchev, Y},
doi = {10.1038/s41467-017-00549-w},
journal = {Nature Communications},
title = {Nanopore Extended Field Effect Transistor for Selective Single Molecule Biosensing},
url = {http://dx.doi.org/10.1038/s41467-017-00549-w},
volume = {8},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - There has been a significant drive to deliver nanotechnological solutions to biosensing, yet there remains an unmet need in the development of biosensors that are affordable, integrated, fast, capable of multiplexed detection, and offer high selectivity for trace analyte detection in biological fluids. Herein, some of these challenges are addressed by designing a new class of nanoscale sensors dubbed nanopore extended field-effect transistor (nexFET) that combine the advantages of nanopore single-molecule sensing, field-effect transistors, and recognition chemistry. We report on a polypyrrole functionalized nexFET, with controllable gate voltage that can be used to switch on/off, and slow down single-molecule DNA transport through a nanopore. This strategy enables higher molecular throughput, enhanced signal-to-noise, and even heightened selectivity via functionalization with an embedded receptor. This is shown for selective sensing of an anti-insulin antibody in the presence of its IgG isotype.
AU - Ren,R
AU - Zhang,Y
AU - Paulose,Nadappuram B
AU - Akpinar,B
AU - Klenerman,D
AU - Ivanov,AP
AU - Edel,JB
AU - Korchev,Y
DO - 10.1038/s41467-017-00549-w
PY - 2017///
SN - 2041-1723
TI - Nanopore Extended Field Effect Transistor for Selective Single Molecule Biosensing
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/s41467-017-00549-w
UR - http://hdl.handle.net/10044/1/50106
VL - 8
ER -