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@article{Ivanov:2015:10.1021/acsnano.5b00911,
author = {Ivanov, AP and Actis, P and Jönsson, P and Klenerman, DK and Korchev, Y and Edel, JB},
doi = {10.1021/acsnano.5b00911},
journal = {ACS Nano},
pages = {3587--3595},
title = {On-demand delivery of single DNA molecules using nanopipettes},
url = {http://dx.doi.org/10.1021/acsnano.5b00911},
volume = {9},
year = {2015}
}

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TY  - JOUR
AB  - Understanding the behavioral properties of single molecules or larger scale populations interacting with single molecules is currently a hotly pursued topic in nanotechnology. This arises from the potential such techniques have in relation to applications such as targeted drug delivery, early stage detection of disease, and drug screening. Although label and label-free single molecule detection strategies have existed for a number of years, currently lacking are efficient methods for the controllable delivery of single molecules in aqueous environments. In this article we show both experimentally and from simulations that nanopipets in conjunction with asymmetric voltage pulses can be used for label-free detection and delivery of single molecules through the tip of a nanopipet with “on-demand” timing resolution. This was demonstrated by controllable delivery of 5 kbp and 10 kbp DNA molecules from solutions with concentrations as low as 3 pM.
AU  - Ivanov,AP
AU  - Actis,P
AU  - Jönsson,P
AU  - Klenerman,DK
AU  - Korchev,Y
AU  - Edel,JB
DO  - 10.1021/acsnano.5b00911
EP  - 3595
PY  - 2015///
SN  - 1936-086X
SP  - 3587
TI  - On-demand delivery of single DNA molecules using nanopipettes
T2  - ACS Nano
UR  - http://dx.doi.org/10.1021/acsnano.5b00911
UR  - http://pubs.acs.org/doi/abs/10.1021/acsnano.5b00911
UR  - http://hdl.handle.net/10044/1/23518
VL  - 9
ER  -

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Professor Joshua B. Edel

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