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@article{Wang:2023:10.1002/cam4.5344,
author = {Wang, P and Wang, Z and Zhu, L and Sun, Y and Castellano, L and Stebbing, J and Yu, Z and Peng, L},
doi = {10.1002/cam4.5344},
journal = {Cancer Medicine},
pages = {6348--6364},
title = {A pyroptosis-related lncRNA signature in bladder cancer},
url = {http://dx.doi.org/10.1002/cam4.5344},
volume = {12},
year = {2023}
}

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TY  - JOUR
AB  - PurposePyroptosis, a type of programmed cell death, is implicated in the tumorigenesis, development and migration of cancer, which can be regulated by long non-coding RNAs (lncRNAs). Our research aimed to investigate the prognostic role of pyroptosis-related lncRNAs and the relationship to the tumor immune microenvironment through bioinformatics analysis.MethodsThe clinical and RNA-sequencing data of bladder cancer patients were downloaded from The Cancer Genome Atlas (TCGA). And 412 bladder cancer subjects with clinical information were divided into training and testing cohort. And 52 reported pyroptosis-related genes were used to screen pyroptosis-related lncRNAs. A pyroptosis-related lncRNA signature was constructed based on Cox regression analyses.ResultsA 9-pyroptosis-related-lncRNA signature was identified to separate patients with bladder cancer into two groups. The prognosis of bladder cancer patients in the high-risk group was significantly inferior compared with those in the low-risk group. Risk scores were validated to develop an independent prognostic indicator based on multivariate Cox regression analysis. Receiver operating characteristic curve (ROC) analysis examined the signature on overall survival. The area under time-dependent ROC curve (AUC) at 1-, 3, and 5-years measured 0.747, 0.783, and 0.768, respectively. Analysis of the immune landscape and PD-L1 expression showed that PD-L1 is upregulated in the high-risk group. The immunocyte subtypes of the two groups were different.ConclusionA novel pyroptosis-related lncRNA signature was identified with prognostic value for bladder cancer patients. Pyroptosis-related lncRNAs have a potential role in cancer immunology and may serve as prognostic or therapeutic targets.
AU  - Wang,P
AU  - Wang,Z
AU  - Zhu,L
AU  - Sun,Y
AU  - Castellano,L
AU  - Stebbing,J
AU  - Yu,Z
AU  - Peng,L
DO  - 10.1002/cam4.5344
EP  - 6364
PY  - 2023///
SN  - 2045-7634
SP  - 6348
TI  - A pyroptosis-related lncRNA signature in bladder cancer
T2  - Cancer Medicine
UR  - http://dx.doi.org/10.1002/cam4.5344
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000867468100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://onlinelibrary.wiley.com/doi/10.1002/cam4.5344
UR  - http://hdl.handle.net/10044/1/104168
VL  - 12
ER  -

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