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@article{Casalini:2022:10.3390/diagnostics12112813,
author = {Casalini, E and Piro, R and Fontana, M and Rossi, L and Ghinassi, F and Taddei, S and Mengoli, MC and Magnani, L and Beghè, B and Facciolongo, N},
doi = {10.3390/diagnostics12112813},
journal = {Diagnostics},
title = {Diagnosis of Organizing Pneumonia with an Ultrathin Bronchoscope and Cone-Beam CT: A Case Report},
url = {http://dx.doi.org/10.3390/diagnostics12112813},
volume = {12},
year = {2022}
}

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TY - JOUR
AB - Organizing pneumonia (OP) is a pulmonary disease histopathologically characterized by plugs of loose connective tissue in distal airways. The clinical and radiological presentations are not specific and they usually require a biopsy confirmation. This paper presents the case of a patient with a pulmonary opacity sampled with a combined technique of ultrathin bronchoscopy and cone-beam CT. A 64-year-old female, a former smoker, was admitted to the hospital of Reggio Emilia (Italy) for exertional dyspnea and a dry cough without a fever. The history of the patient included primary Sjögren Syndrome interstitial lung disease (pSS-ILD) characterized by a non-specific interstitial pneumonia (NSIP) radiological pattern; this condition was successfully treated up to 18 months before the new admission. The CT scan showed the appearance of a right lower lobe pulmonary opacity of an uncertain origin that required a histological exam for the diagnosis. The lung lesion was difficult to reach with traditional bronchoscopy and a percutaneous approach was excluded. Thus, cone-beam CT, augmented fluoroscopy and ultrathin bronchoscopy were chosen to collect a tissue sample. The histopathological exam was suggestive of OP, a condition occurring in 4–11% of primary Sjögren Syndrome cases. This case showed that, in the correct clinical and radiological context, even biopsies taken with small forceps can lead to a diagnosis of OP. Moreover, it underlined that the combination of multiple advanced technologies in the same procedure can help to reach difficult target lesions, providing proper samples for a histological diagnosis.
AU - Casalini,E
AU - Piro,R
AU - Fontana,M
AU - Rossi,L
AU - Ghinassi,F
AU - Taddei,S
AU - Mengoli,MC
AU - Magnani,L
AU - Beghè,B
AU - Facciolongo,N
DO - 10.3390/diagnostics12112813
PY - 2022///
TI - Diagnosis of Organizing Pneumonia with an Ultrathin Bronchoscope and Cone-Beam CT: A Case Report
T2 - Diagnostics
UR - http://dx.doi.org/10.3390/diagnostics12112813
VL - 12
ER -

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