Imperial College London

ProfessorMarjo-RiittaJarvelin

Faculty of MedicineSchool of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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Contact

 

m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zhou:2018:10.1038/s41598-018-25919-2,
author = {Zhou, A and Taylor, AE and Karhunen, V and Zhan, Y and Rovio, SP and Lahti, J and Sjogren, P and Byberg, L and Lyall, DM and Auvinen, J and Lehtimaki, T and Kahonen, M and Hutri-Kahonen, N and Perala, MM and Michaelsson, K and Mahajan, A and Lind, L and Power, C and Eriksson, JG and Raitakari, OT and Hagg, S and Pedersen, NL and Veijola, J and Jarvelin, M-R and Munafo, MR and Ingelsson, E and Llewellyn, DJ and Hypponen, E},
doi = {10.1038/s41598-018-25919-2},
journal = {Scientific Reports},
title = {Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants},
url = {http://dx.doi.org/10.1038/s41598-018-25919-2},
volume = {8},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Coffee’s long-term effect on cognitive function remains unclear with studies suggesting both benefits and adverse effects. We used Mendelian randomization to investigate the causal relationship between habitual coffee consumption and cognitive function in mid- to later life. This included up to 415,530 participants and 300,760 coffee drinkers from 10 meta-analysed European ancestry cohorts. In each cohort, composite cognitive scores that capture global cognition and memory were computed using available tests. A genetic score derived using CYP1A1/2 (rs2472297) and AHR (rs6968865) was chosen as a proxy for habitual coffee consumption. Null associations were observed when examining the associations of the genetic score with global and memory cognition (β = −0.0007, 95% C.I. −0.009 to 0.008, P = 0.87; β = −0.001, 95% C.I. −0.005 to 0.002, P = 0.51, respectively), with high consistency between studies (Pheterogeneity > 0.4 for both). Domain specific analyses using available cognitive measures in the UK Biobank also did not support effects by habitual coffee intake for reaction time, pairs matching, reasoning or prospective memory (P ≥ 0.05 for all). Despite the power to detect very small effects, our meta-analysis provided no evidence for causal long-term effects of habitual coffee consumption on global cognition or memory.
AU - Zhou,A
AU - Taylor,AE
AU - Karhunen,V
AU - Zhan,Y
AU - Rovio,SP
AU - Lahti,J
AU - Sjogren,P
AU - Byberg,L
AU - Lyall,DM
AU - Auvinen,J
AU - Lehtimaki,T
AU - Kahonen,M
AU - Hutri-Kahonen,N
AU - Perala,MM
AU - Michaelsson,K
AU - Mahajan,A
AU - Lind,L
AU - Power,C
AU - Eriksson,JG
AU - Raitakari,OT
AU - Hagg,S
AU - Pedersen,NL
AU - Veijola,J
AU - Jarvelin,M-R
AU - Munafo,MR
AU - Ingelsson,E
AU - Llewellyn,DJ
AU - Hypponen,E
DO - 10.1038/s41598-018-25919-2
PY - 2018///
SN - 2045-2322
TI - Habitual coffee consumption and cognitive function: a Mendelian randomization meta-analysis in up to 415,530 participants
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-018-25919-2
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000431958000003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/59795
VL - 8
ER -