Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Karjula:2020:clinem/dgz256,
author = {Karjula, S and Morin-Papunen, L and Franks, S and Auvinen, J and Järvelin, M-R and Tapanainen, JS and Jokelainen, J and Miettunen, J and Piltonen, TT},
doi = {clinem/dgz256},
journal = {Journal of Clinical Endocrinology and Metabolism},
pages = {1--13},
title = {Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms.},
url = {http://dx.doi.org/10.1210/clinem/dgz256},
volume = {105},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - CONTEXT: Polycystic ovary syndrome (PCOS) is associated with decreased health-related quality of life (HRQoL), but longitudinal data beyond the reproductive years are lacking, and the impact of isolated PCOS symptoms is unclear. OBJECTIVE: To study generic HRQoL using 15D, life satisfaction, and self-reported health status in women with PCOS symptoms at ages 31 and 46yr. DESIGN: A longitudinal assessment using the Northern Finland Birth Cohort 1966. SETTING: General community. PARTICIPANTS: The 15D data were available for women reporting isolated oligomenorrhea (OA;at age 31yr:214 and 46yr: 211), isolated hirsutism (H; 31yr:211 and 46yr:216), OA+H (PCOS; 31yr:74 and 46yr:75), or no PCOS symptoms (controls; 31yr:1382 and 46yr:1412). Data for life satisfaction and current health status were available for OA (31yr:329 and 46yr:247), H (31yr:323 and 46yr:238), PCOS (31yr:125 and 46yr:86), control (31yr:2182 and 46yr:1613) groups. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): 15D HRQoL, questionnaires on life satisfaction, and self-reported health status. RESULTS: HRQoL was lower at ages 31 and 46 in women with PCOS or H compared with the controls. PCOS was an independent risk factor for low HRQoL, and the decrease in HRQoL in PCOS was comparable to that of women with other chronic conditions, like asthma, migraine, rheumatoid arthritis, and depression. The risk for low HRQoL in PCOS remained significant after adjusting for BMI, hyperandrogenism, and socioeconomic status. Mental distress was the strongest contributing factor to HRQoL. PCOS was also associated with a risk for low life satisfaction and a 4-fold risk for reporting a poor health status. CONCLUSIONS: Women with PCOS present with low HRQoL, decreased life satisfaction, and a poorer self-reported health status up to their late reproductive years. Assessments and interventions aiming to improve HRQoL in PCOS should be targeted beyond fertile age.
AU  - Karjula,S
AU  - Morin-Papunen,L
AU  - Franks,S
AU  - Auvinen,J
AU  - Järvelin,M-R
AU  - Tapanainen,JS
AU  - Jokelainen,J
AU  - Miettunen,J
AU  - Piltonen,TT
DO  - clinem/dgz256
EP  - 13
PY  - 2020///
SN  - 0021-972X
SP  - 1
TI  - Population-based data at ages 31 and 46 show decreased HRQoL and life satisfaction in women with PCOS symptoms.
T2  - Journal of Clinical Endocrinology and Metabolism
UR  - http://dx.doi.org/10.1210/clinem/dgz256
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31970392
UR  - https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgz256/5709653
UR  - http://hdl.handle.net/10044/1/76477
VL  - 105
ER  -
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