Imperial College London
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ProfessorMarjo-RiittaJarvelin

Faculty of Medicine, School of Public Health

Chair in Lifecourse Epidemiology
 
 
 
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m.jarvelin

 
 
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Location

 

302School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gormley:2016:10.1038/ng.3598,
author = {Gormley, P and Anttila, V and Winsvold, BS and Palta, P and Esko, T and Pers, TH and Farh, K-H and Cuenca-Leon, E and Muona, M and Furlotte, NA and Kurth, T and Ingason, A and McMahon, G and Ligthart, L and Terwindt, GM and Kallela, M and Freilinger, TM and Ran, C and Gordon, SG and Stam, AH and Steinberg, S and Borck, G and Koiranen, M and Quaye, L and Adams, HHH and Lehtimaki, T and Sarin, A-P and Wedenoja, J and Hinds, DA and Buring, JE and Schurks, M and Ridker, PM and Hrafnsdottir, MG and Stefansson, H and Ring, SM and Hottenga, J-J and Penninx, BWJH and Farkkila, M and Artto, V and Kaunisto, M and Vepsalainen, S and Malik, R and Heath, AC and Madden, PAF and Martin, NG and Montgomery, GW and Kurki, MI and Kals, M and Magi, R and Parn, K and Hamalainen, E and Huang, H and Byrnes, AE and Franke, L and Huang, J and Stergiakouli, E and Lee, PH and Sandor, C and Webber, C and Cader, Z and Muller-Myhsok, B and Schreiber, S and Meitinger, T and Eriksson, JG and Salomaa, V and Heikkila, },
doi = {10.1038/ng.3598},
journal = {Nature Genetics},
pages = {856--866},
title = {Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine},
url = {http://dx.doi.org/10.1038/ng.3598},
volume = {48},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10−8) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.
AU  - Gormley,P
AU  - Anttila,V
AU  - Winsvold,BS
AU  - Palta,P
AU  - Esko,T
AU  - Pers,TH
AU  - Farh,K-H
AU  - Cuenca-Leon,E
AU  - Muona,M
AU  - Furlotte,NA
AU  - Kurth,T
AU  - Ingason,A
AU  - McMahon,G
AU  - Ligthart,L
AU  - Terwindt,GM
AU  - Kallela,M
AU  - Freilinger,TM
AU  - Ran,C
AU  - Gordon,SG
AU  - Stam,AH
AU  - Steinberg,S
AU  - Borck,G
AU  - Koiranen,M
AU  - Quaye,L
AU  - Adams,HHH
AU  - Lehtimaki,T
AU  - Sarin,A-P
AU  - Wedenoja,J
AU  - Hinds,DA
AU  - Buring,JE
AU  - Schurks,M
AU  - Ridker,PM
AU  - Hrafnsdottir,MG
AU  - Stefansson,H
AU  - Ring,SM
AU  - Hottenga,J-J
AU  - Penninx,BWJH
AU  - Farkkila,M
AU  - Artto,V
AU  - Kaunisto,M
AU  - Vepsalainen,S
AU  - Malik,R
AU  - Heath,AC
AU  - Madden,PAF
AU  - Martin,NG
AU  - Montgomery,GW
AU  - Kurki,MI
AU  - Kals,M
AU  - Magi,R
AU  - Parn,K
AU  - Hamalainen,E
AU  - Huang,H
AU  - Byrnes,AE
AU  - Franke,L
AU  - Huang,J
AU  - Stergiakouli,E
AU  - Lee,PH
AU  - Sandor,C
AU  - Webber,C
AU  - Cader,Z
AU  - Muller-Myhsok,B
AU  - Schreiber,S
AU  - Meitinger,T
AU  - Eriksson,JG
AU  - Salomaa,V
AU  - Heikkila,K
AU  - Loehrer,E
AU  - Uitterlinden,AG
AU  - Hofman,A
AU  - van,Duijn CM
AU  - Cherkas,L
AU  - Pedersen,LM
AU  - Stubhaug,A
AU  - Nielsen,CS
AU  - Mannikko,M
AU  - Mihailov,E
AU  - Milani,L
AU  - Gobel,H
AU  - Esserlind,A-L
AU  - Christensen,AF
AU  - Hansen,TF
AU  - Werge,T
AU  - Kaprio,J
AU  - Aromaa,AJ
AU  - Raitakari,O
AU  - Ikram,MA
AU  - Spector,T
AU  - Jarvelin,M-R
AU  - Metspalu,A
AU  - Kubisch,C
AU  - Strachan,DP
AU  - Ferrari,MD
AU  - Belin,AC
AU  - Dichgans,M
AU  - Wessman,M
AU  - van,den Maagdenberg AMJM
AU  - Zwart,J-A
AU  - Boomsma,DI
AU  - Smith,GD
AU  - Stefansson,K
AU  - Eriksson,N
AU  - Daly,MJ
AU  - Neale,BM
AU  - Olesen,J
AU  - Chasman,DI
AU  - Nyholt,DR
AU  - Palotie,A
DO  - 10.1038/ng.3598
EP  - 866
PY  - 2016///
SN  - 1546-1718
SP  - 856
TI  - Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
T2  - Nature Genetics
UR  - http://dx.doi.org/10.1038/ng.3598
UR  - http://hdl.handle.net/10044/1/41116
VL  - 48
ER  -
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